Molecular Biology of the Cell

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Molecular Biology of the Cell

Molecular Biology of the Cell

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Bacterial Chemotaxis Depends on a Two-Component Signaling Pathway Activated by Histidine-Kinase-associated Receptors Phospholipid Exchange Proteins Help to Transport Phospholipids from the ER to Mitochondria and Peroxisomes The Normal Gene in a Cell Can Be Directly Replaced by an Engineered Mutant Gene in Bacteria and Some Lower Eucaryotes Protein Transport into the Inner Mitochondrial Membrane and the Intermembrane Space Requires Two Signal Sequences

In Multicellular Animals and Most Plants, the Diploid Phase Is Complex and Long, the Haploid Simple and Fleeting Many Proteins and Lipids Seem to Be Carried Automatically from the Golgi Apparatus to the Cell Surface Highly Condensed Chromatin Replicates Late, While Genes in Less Condensed Chromatin Tend to Replicate Early All Cells Transcribe Portions of Their Hereditary Information into the Same Intermediary Form (RNA) Notch Signaling Regulates the Fine-Grained Pattern of Differentiated Cell Types in Many Different TissuesA step-by-step account of the operation of the ribosome whose fine-grained structure has recently been solved: how messenger RNA binds to the ribosome substrate and how the transfer RNA is brought into juxtaposition with it so that the right amino acid residue corresponding to the codon can be attached to the growing polypeptide chain. Not only can the process be spelled out in atomic-level detail, but there is some understanding of how error correction works to ensure high fidelity. The Positioning of Nucleosomes on DNA Is Determined by Both DNA Flexibility and Other DNA-bound Proteins A Strand-directed Mismatch Repair System Removes Replication Errors That Escape from the Replication Machine

Mammalian cells occasionally undergo mutations that allow them to proliferate readily and indefinitely in culture as “immortalized” cell lines. Although they are not normal, such cell lines are used widely for cell-cycle studies—and for cell biology generally—because they provide an unlimited source of genetically homogeneous cells. In addition, these cells are sufficiently large to allow detailed cytological observations of cell-cycle events, and they are amenable to biochemical analysis of the proteins involved in cell-cycle control. A Comparison of Human and Mouse Chromosomes Shows How The Large-scale Structures of Genomes Diverge Neuromuscular Transmission Involves the Sequential Activation of Five Different Sets of Ion Channels Lipid Rafts May Mediate Sorting of Glycosphingolipids and GPI-anchored Proteins to the Apical Plasma Membrane Spectrin Is a Cytoskeletal Protein Noncovalently Associated with the Cytosolic Side of the Red Blood Cell MembraneA mere high-level listing of a sampling of subjects covered such as this cannot do justice to all the admirable features of Alberts’ text. In every case, the exposition of a process involves not just a summary of its purpose and how it functions, but names the individual molecular species that participate in it and outlines the mechanism by which they interact, where known, which is most often the case. Well designed schematic figures, diagrams, tables and photographs illustrate in pictures what is said in the text and considerably facilitate understanding. Confronted with such an overwhelming wealth of material, we can only call out a few characteristic and particularly striking points in the authors’ exposition: An Egg Is Highly Specialized for Independent Development, with Large Nutrient Reserves and an Elaborate Coat Polarized Cells Direct Proteins from the Trans Golgi Network to the Appropriate Domain of the Plasma Membrane

Basal Laminae Are Composed Mainly of Type IV Collagen, Laminin, Nidogen, and a Heparan Sulfate Proteoglycan Noncovalent Bonds Specify Both the Precise Shape of a Macromolecule and its Binding to Other Molecules A Signal-Recognition Particle (SRP) Directs ER Signal Sequences to a Specific Receptor in the Rough ER Membrane Bcl-2 Family Proteins and IAP Proteins Are the Main Intracellular Regulators of the Cell Death ProgramAnchoring Junctions Connect the Cytoskeleton of a Cell Either to the Cytoskeleton of Its Neighbors or to the Extracellular Matrix Homeotic Selector Genes Code for DNA-Binding Proteins That Interact with Other Gene Regulatory Proteins Expression of a Critical Gene Regulatory Protein Can Trigger Expression of a Whole Battery of Downstream Genes How photosynthesis occurs – collection of the infalling light inside the chloroplast, conversion of the photon’s energy into a resonant state of the chlorophyll and its transfer from the antenna complex to the reaction center, where a weak electron donor is promoted to a strong one.

More Than 1000 Proteins Can Be Resolved on a Single Gel by Two-dimensional Polyacrylamide-Gel Electrophoresis The Modular Nature of Regulatory DNA Allows Genes to Have Multiple Independently Controlled Functions Other Polymeric Proteins Also Use Nucleotide Hydrolysis to Couple a Conformational Change to Cell Movements The Size and Subunit Composition of a Protein Can Be Determined by SDS Polyacrylamide-Gel Electrophoresis

Molecular Biology of the Cell. 4th edition.

Three Classes of Segmentation Genes Refine the Anterior- Posterior Maternal Pattern and Subdivide the Embryo Along with molecular biology of the cell pdf book here are some more important books that you can look after for a better understanding and more information of the molecular biology. chapter 11 Membrane Transport of Small Molecules and the Electrical Properties of Membranes / Bruce Alberts --



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