Denamarin is the #1 Vet recommended liver support brand for dogs and cats. It is sold exclusively through veterinary suppliers as adjunctive treatment for liver disease or dysfunction, such as the following: Although available over the counter, never give this supplement without first consulting with a veterinarian [3]. There are three sizes of the tablet, based on their strength – large, medium, small. The small tablets are usually prescribed for cats, given once or twice daily depending on your cat’s body weight [1]:

In a pharmacokinetic study with fasted dogs given a S-Adenosylmethionine chewable tablet versus an enteric coated S-Adenosylmethionine tablet, bioavailability was found to be comparable between the two formulations. The time course of uptake, however, was significantly more rapid and consistent with the chewable tablet compared to the enteric coated S-Adenosylmethionine tablet. 31 Silybin is the major active component of silymarin, which is found naturally in the milk thistle plant. Silybin acts as a liver protectant chiefly through preventing toxin penetration into liver cells. It also inhibits toxic and inflammatory effects on cells, and acts as an antioxidant and free radical scavenger.Interactions with other medications: Denamarin may interact with certain medications, such as nonsteroidal anti-inflammatory drugs (NSAIDs) or anticoagulants. It is important to inform your veterinarian of all medications and supplements that your cat is currently taking to avoid any potential interactions. For cats weighing less than 6 pounds: 1 tablet of Denamarin for Cats and Small Dogs (90mg SAMe/9mg silybin)

For about three weeks now this has yielded about 95% success on the first try. A few times he’s super sneaky and spit it out…lol. The number of tablets administered may gradually be reduced, or increased, at any time at the recommendation of your veterinary surgeon. He gets two big pills daily, chemo which I can't touch without gloves, a little half cerenia for nausea, and liquid syringes of steroids for cancer fighting, Zofran for nausea too, and gabapentin for pain. All at night. Now lysine gel rubbed on his gums for antiviral because he's stressed and is congested plus I clean his nose. Mornings a syringe each of gabapentin and Zofran. S-Adenosylmethionine, Silybin A+B What is the most important thing I should know about Denamarin Tablets?The number of tablets administered may be gradually reduced or increased at any time at your veterinarian’s recommendation. Denamarin helps to support the liver which is one of the largest organs in the body. How does it work? I gave my cat the pill for a couple of months and started seeing some improvements in her blood works, but I eventually had to stop giving her the pills because she was getting intolerant to the external protective film of the pills. Silybin is an antioxidant that helps to protect against harmful free radicals, further supporting your pet’s liver function. It also supports the flow of bile through the liver, helping your pet digest and absorb food effectively. As well as helping the liver to effectively perform it also helps with liver repair and increases levels of glutathione.