As of 2019, fourteen countries require food fortification of wheat flour, maize flour or rice with vitamin B 6 as pyridoxine hydrochloride. Most of these are in southeast Africa or Central America. The amounts stipulated range from 3.0 to 6.5mg/kg. An additional seven countries, including India, have a voluntary fortification program. India stipulates 2.0mg/kg. [31] Dietary supplements [ edit ] A three-month study in over 60 premenopausal women found that taking 50 mg of vitamin B6 daily improved PMS symptoms of depression, irritability and tiredness by 69% ( 23).

a b c d Rosenberg IH (2012). "A history of the isolation and identification of vitamin B(6)". Ann Nutr Metab. 61 (3): 236–8. doi: 10.1159/000343113. PMID 23183295. S2CID 37156675.The reason why B6 may help prevent cancer is unclear, but researchers suspect that it’s related to its ability to fight inflammation that may contribute to cancer and other chronic conditions ( 34, 35).

Cooking, storage, and processing losses vary, and in some foods may be more than 50% depending on the form of vitamin present in the food. [3] Plant foods lose less during processing, as they contain pyridoxine, which is more stable than the pyridoxal or pyridoxamine forms found in animal-sourced foods. For example, milk can lose 30–70% of its vitamin B 6 content when dried. [15] The vitamin is found in the germ and aleurone layer of grains, so there is more in whole wheat bread compared to white bread wheat, and more in brown rice compared to white rice. [30] However, it’s unclear if supplementing with B6 decreases inflammation in people with this condition. This is likely due to the role of B6 in decreasing elevated homocysteine levels associated with several disease processes, including heart disease ( 31, 32, 33). Above is the important information about the drug Magne B6. Patients can consult more and consult a doctor before using.Ford AH, Almeida OP (May 2019). "Effect of Vitamin B Supplementation on Cognitive Function in the Elderly: A Systematic Review and Meta-Analysis". Drugs Aging. 36 (5): 419–34. doi: 10.1007/s40266-019-00649-w. PMID 30949983. S2CID 96435344. Hemoglobin is a protein that delivers oxygen to your cells. When you have low hemoglobin, your cells don’t get enough oxygen. As a result, you may develop anemia and feel weak or tired. While it appears that high doses of vitamin B6 supplements may provide anti-inflammatory benefits for people with rheumatoid arthritis over time, more research is needed.

Ulvik A, Midttun Ø, Pedersen ER, Eussen SJ, Nygård O, Ueland PM (July 2014). "Evidence for increased catabolism of vitamin B-6 during systemic inflammation". The American Journal of Clinical Nutrition. 100 (1): 250–5. doi: 10.3945/ajcn.114.083196. PMID 24808485. PLP is an essential component of enzymes that facilitate the biosynthesis of sphingolipids. [15] Particularly, the synthesis of ceramide requires PLP. In this reaction, serine is decarboxylated and combined with palmitoyl-CoA to form sphinganine, which is combined with a fatty acyl-CoA to form dihydroceramide. This compound is then further desaturated to form ceramide. In addition, the breakdown of sphingolipids is also dependent on vitamin B 6 because sphingosine-1-phosphate lyase, the enzyme responsible for breaking down sphingosine-1-phosphate, is also PLP-dependent. Harris SA, Folkers K (April 1939). "Synthetic vitamin B6". Science. 89 (2311): 347. Bibcode: 1939Sci....89..347H. doi: 10.1126/science.89.2311.347. PMID 17788439.

PLP is a cofactor in the biosynthesis of five important neurotransmitters: serotonin, dopamine, epinephrine, norepinephrine, and gamma-aminobutyric acid. [6] A case study in a 72-year-old woman with anemia due to low B6 found that treatment with the most active form of vitamin B6 improved symptoms ( 22). Kobayashi D (2019). "[Food Poisoning by Ginkgo Seeds through Vitamin B6 Depletion]". Yakugaku Zasshi (in Japanese). 139 (1): 1–6. doi: 10.1248/yakushi.18-00136. PMID 30606915. Map: Count of Nutrients In Fortification Standards". Global Fortification Data Exchange. 16 August 2021 . Retrieved 16 August 2021. a b "Tolerable Upper Intake Levels For Vitamins And Minerals" (PDF). European Food Safety Authority. 2006. Archived (PDF) from the original on 19 September 2017.