One test-tube study found that guava leaf extract was effective at killing acne-causing bacteria — likely due to its antimicrobial and anti-inflammatory properties ( 24). Since the cell membrane is broken and the fibers are cut by steaming and twisting, guava tea from which polyphenols, which are the active ingredient of guava leaf, are sufficiently extracted can be provided. In addition, the improvement of diabetes symptoms, such as hyperglycemia, nephropathy (Table ​ (Table1) 1) and insulin resistance, has been reported with the consecutive ingestion of GvEx in diabetic animal models [ 15]. have reviewed the potential pharmacologic activities of the extract from the fruit, leaf, bark or roots; these activities include antioxidant, hepatoprotective, anti-allergy, anti-microbial, anti-genotoxic, anti-plasmodial, cytotoxic, anti-spasmodic, cardioactive, anti-cough, anti-diabetic, anti-inflammatory and anti-nociceptive activities in vitro and/or in animal models.

On day 2, the subjects in groups A and B were administered Guava Leaf Tea (200 ml) with meal and voglibose (3 mg) before meal, respectively.A subsequent histopathological study showed the absence of response to the induction of P450 isoforms in the liver of rats with 1-month repeated oral administration of GvEx (2000 mg/kg/day). As shown in Figure ​ Figure3, 3, the postprandial glucose level 2 hours after meal was elevated to ca. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.

Here, it was shown that the GvEx acts as an alpha-GI in vitro and contains GvPP as the active component. There are several compounds in the leaves that may contribute to these properties including flavonoids, tannins, and acids (gallic and betulinic). In addition, previous in vitro studies and investigations using animal models have demonstrated that Guava Leaf Tea and GvEx induce neither toxicity nor mutagenicity.The FBG and postprandial blood glucose levels were assayed before and 2 hours after meal, respectively. Effects of guava intake on serum total and high-density lipoprotein cholesterol levels and on systemic blood pressure. Though guava trees are now cultivated in Florida, Hawaii, Southern California, China, and India, the plant is native to Central America and southern Mexico.