Its overall size and weight is very well-suited to a camera like the Nikon Z50 that we tested it with, as shown in the product photos. Concomitant use of systemic ketoconazole significantly increases systemic exposure to salmeterol. This may lead to an increase in the incidence of systemic effects (e.g. prolongation in the QTc interval and palpitations). Concomitant treatment with ketoconazole or other potent CYP3A4 inhibitors should therefore be avoided unless the benefits outweigh the potentially increased risk of systemic side effects of salmeterol treatment (see section 4.5). Bokeh, the feel, character or quality of out-of-focus areas as opposed to how far out of focus they are, is pretty good; but with a lens this slow nothing ever gets that far out of focus except at the longer end.

Seretide 50/250 Accuhaler may cause some side effects like headache, throat irritation, stuffy nose, and hoarseness of voice. Inform your doctor if these side effects remain for a long time or become severe. Avoid using it if you are allergic to it. Cushing's syndrome, Cushingoid features, Adrenal suppression, Growth retardation in children and adolescents, Decreased bone mineral density The Salmeterol Multi-center Asthma Research Trial (SMART) was a 28-week US study that evaluated the safety of salmeterol compared to placebo added to usual therapy in adult and adolescent subjects. Although there were no significant differences in the primary endpoint of the combined number of respiratory-related deaths and respiratory-related life-threatening experiences, the study showed a significant increase in asthma-related deaths in patients receiving salmeterol (13 deaths out of 13,176 patients treated with salmeterol versus 3 deaths out of 13,179 patients on placebo). The study was not designed to assess the impact of concurrent inhaled corticosteroid use, and only 47% of subjects reported ICS use at baseline. This lens has a button-free retractable design - all you have to do is rotate the zoom ring to extend the lens before you can press the shutter button to take a picture. The Nikon Z DX 50-250mm F4.5-6.3 VR lens has a ridged motor-assisted focus ring that is quite nicely damped. Manual focusing is possible by selecting it on the camera body or full-time manual focus override is also possible when in AF mode.

The Nikon Z DX 50-250mm F4.5-6.3 VR produces quite nice sunstars when set to 50mm and stopped-down to f/22 or greater, as shown below. Flare is well controlled even when shooting directly into the sun without a lens hood fitted. Macro You can use the control ring to manually focus by default, but you can customise it to access various camera functions, such as aperture, ISO speed or exposure compensation. This is something you can set via the camera’s main menu and can be quite handy in certain circumstances. Using the algebraic simplification process, we can arithmetically manipulate the above equation as follows: A short-term trial of Seretide may be considered as initial maintenance therapy in adults or adolescents with moderate persistent asthma (defined as patients with daily symptoms, daily rescue use and moderate to severe airflow limitation) for whom rapid control of asthma is essential. In these cases, the recommended initial dose is one inhalation of 50 micrograms salmeterol and 100 micrograms fluticasone propionate twice daily. Once control of asthma is attained treatment should be reviewed and consideration given as to whether patients should be stepped down to an inhaled corticosteroid alone. Regular review of patients as treatment is stepped down is important.

A total of 11,679 and 6,208 subjects were randomized and received treatment in the AUSTRI and VESTRI trials, respectively. For the primary safety endpoint, non-inferiority was achieved for both trials (see Table below).

It measures 74 x 110mm / 3x 4" when set to the 50mm focal length, making it one of the smallest ultra-zoom lenses currently available for Nikon's Z-series mirrorless cameras.

Two multi-centre 26-week studies were conducted to compare the safety and efficacy of salmeterol-FP versus FP alone, one in adult and adolescent subjects (AUSTRI trial), and the other in paediatric subjects 4-11 years of age (VESTRI trial). For both studies, enrolled subjects had moderate to severe persistent asthma with history of asthma-related hospitalisation or asthma exacerbation in the previous year. The primary objective of each study was to determine whether the addition of LABA to ICS therapy (salmeterol-FP) was non-inferior to ICS (FP) alone in terms of the risk of serious asthma related events (asthma-related hospitalisation, endotracheal intubation, and death). A secondary efficacy objective of these studies was to evaluate whether ICS/LABA (salmeterol-FP) was superior to ICS therapy alone (FP) in terms of severe asthma exacerbation (defined as deterioration of asthma requiring the use of systemic corticosteroids for at least 3 days or an in-patient hospitalisation or emergency department visit due to asthma that required systemic corticosteroids). This 50-250mm lens is absolutely brilliant. It's small, light weight, collapses for carrying, focusses super-close, has great image stabilization (VR), and is optically essentially flawless. Interesting. The 8-25, 12-45 & 40-150 f4 have all come to fruition. That apparently leaves only the 50-200, 50-250 and bright primes in the works. At least from the lenses on the roadmap. They could have other things in the works they haven’t told us about - didn’t the 40-150 f4 arrive with relatively little forewarning?Especially as I write this, you should get this 50-250mm lens along with a Z50 as a kit for very little extra money. It's an extraordinary lens and far better than trying to adapt an old lens to your awesome new Z50. Sudden and progressive deterioration in control of asthma is potentially lifethreatening and the patient should undergo urgent medical assessment. This article will explain the full process of finding any percentage value from any given quantity or number with easy and simple steps. well as in studies SCO40043 and SCO100250 comparing the lower nonapproved COPD dose of Seretide, 50/250 micrograms bd, to salmeterol 50

Pharmacotherapeutic Group: Adrenergics in combination with corticosteroids or other drugs, excl. Anticholinergics. A large amount of data on pregnant women (more than 1000 pregnancy outcomes) indicates no malformative or feto/neonatal toxicity related to Seretide. Animal studies have shown reproductive toxicity after administration of β 2 adrenoreceptor agonists and glucocorticosteroids (see section 5.3). We do realise, however, that bokeh evaluation is subjective, so we've included several examples below for your perusal, all shot wide-open. Sharpness A double blind, randomised, parallel group study in 318 patients with persistent asthma aged ≥18 years evaluated the safety and tolerability of administering two inhalations twice daily (double dose) of Seretide for two weeks. The study showed that doubling the inhalations of each strength of Seretide for up to 14 days resulted in a small increase in β agonist-related adverse events (tremor; 1 patient [1%] vs 0, palpitations; 6 [3%] vs 1 [<1%], muscle cramps; 6[3%] vs 1 [<1%]) and a similar incidence of inhaled corticosteroid related adverse events (e.g. oral candidiasis; 6 [6%] vs 16 [8%], hoarseness; 2 [2%] vs 4 [2%]) compared to one inhalation twice daily. The small increase in β agonist-related adverse events should be taken into account if doubling the dose of Seretide is considered by the physician in adult patients requiring additional short-term (up to 14 days) inhaled corticosteroid therapy. Behavioural changes, including psychomotor hyperactivity and irritability (predominantly in children)The pharmacological side effects of β 2 agonist treatment, such as tremor, palpitations and headache, have been reported, but tend to be transient and reduce with regular therapy. There is no need to adjust the dose in elderly patients or in those with renal impairment. There are no data available for use of Seretide in patients with hepatic impairment. An increase in the incidence of pneumonia, including pneumonia requiring hospitalisation, has been observed in patients with COPD receiving inhaled corticosteroids. There is some evidence of an increased risk of pneumonia with increasing steroid dose but this has not been demonstrated conclusively across all studies. Non-significant P value after adjustment for 2 interim analyses on the primary efficacy comparison from a log-rank analysis stratified by smoking status