you need to remember to change it and put in a new one – if remembering to do this is difficult, a longer-acting method such as the contraceptive implant or intrauterine device (IUD) may be more suitable The pharmacokinetic profile of ESTRING vaginal delivery system shows that there is low systemic absorption of estradiol (see section 5.2), however, being a HRT product the following need to be considered, especially for long term or repeated use of this product. Women who may be at risk of pregnancy should be advised to adhere to non-hormonal contraceptive methods. Get emergency medical help if you have any of these signs of an allergic reaction to Estring: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:

For most women, the benefits of the ring outweigh the possible risks, but you should discuss all risk and benefits with a GP or nurse before you start it. Blood clots Tell your doctor about any problems with your vagina, (eg, having an unusually shaped or narrow vagina). Tell your doctor if you have problems with your reproductive organs, bladder, rectum, or pelvic area. if you are allergic to estradiol or similar medicines for hormone replacement therapy, or any of the other ingredients of this medicine (listed in Section 6) Frequency not reported: Vomiting, abdominal cramps, bloating, cholestatic jaundice, increased incidence of gallbladder disease, pancreatitisEpidemiological evidence from a large meta-analysis suggests a slightly increased risk in women taking oestrogen-only systemic HRT, which becomes apparent within 5 years of use and diminishes over time after stopping.

What you should do depends on how long the ring is out for, and which week of your cycle you're in. signs of a blood clot - sudden vision loss, stabbing chest pain, feeling short of breath, coughing up blood, pain or warmth in one or both legs;It is recommended that you have regular screening through the National Breast Cancer Screening Programme and National Cervical Cancer Screening Programme. Your doctor can provide details. You are also recommended to report any changes in your breasts to your doctor as soon as possible.