Some research was conducted on the use of pregnenolone on several populations in the 1930s and 1940s. However, these investigations were replaced by research into other substances in the 1950s because of the possibility of these other substances to be patented by pharmaceutical companies. Since then, little research into the hormone has been conducted. Teen boys may have poor and/or delayed development of secondary sexual characteristics, such as facial hair or deep voice. For patients who cannot attend clinic for their blood tests, we are pleased to have access to a nationwide healthcare provider who can offer professional and convenient phlebotomy and blood sample collection, regardless of where you are located in the UK. Está implicada en la síntesis de: andrógenos, estrógenos y testosterona, modula la transmisión de mensajes neurona a neurona (sinapsis) For normal steroid hormone production, cholesterol is converted into pregnenolone in the adrenal glands. Then several enzymes complete the production of multiple hormones, including:

In the liver, a high cortisol to DHEA ratio will also depress enzyme systems that are critical in detoxing your body. This detox process is important in ridding your body of heavy metals, chemicals, by-products of infectious agents, and waste products. After DHEA is released from the adrenal glands, it is modified in the liver by the addition of a sulphate molecule, so most DHEA circulates in the form of DHEA-sulphate (DHEA-s). DHEA-s is generally considered to be less active than DHEA, but it is usually this level which is measured and used to reflect your DHEA status. Pregnenolone supplement can be converted into progesterone and DHEA, both protective hormones in themselves. It also supports the functioning of the thyroid and other glands. Aldosterone, which maintains normal sodium and potassium levels in the blood and helps control blood volume and pressure Pregnenolone is a steroidal hormone produced mainly in the adrenal glands, but it can also be made in the liver, skin, brain, gonads, and even in the retina of the eye. Synthesized from cholesterol, it has been called the “grandmother” of all the other steroidal hormones. From pregnenolone, DHEA, progesterone, testosterone, and estrogens are made. Because of this, a pregnenolone supplement is one of the first possible avenues considered by physicians who understand AFS.Not for use by individuals under the age of 18 years. Do not use if pregnant or nursing. Consult a physician or licensed qualified healthcare professional before using this product if you have, or have a family history of, prostate neoplasm, prostate enlargement, circulatory disease, low "good" steroid lipids in the blood (HDL), or if you are using any other dietary supplement, prescription drug, or over-the-counter drug. Do not exceed the recommended serving. Exceeding the recommended serving may cause serious adverse health effects. Possible side effects include acne, hair loss, hair growth on the face (in women), aggressiveness, irritability, and increased levels of estrogen. Discontinue use and call a physician or licensed qualified healthcare professional immediately if you experience dizziness, blurred vision, or other similar symptoms. Keep out of reach of children. Stronger muscles, slightly increased stamina. Easier to do exercise. Most of the effects were good, but the spots on my face were not! However, it has been shown that pregnenolone is safe for humans and has minimal side effects, making it a great option for many patients. If you are taking pregnenolone and experience side effects, it is best to consult your doctor and reduce or stop your dose until the side effects go away. Book A Consultation Today

With complex testing like pregnenolone, it’s important to ask your doctor questions about the results. Some to consider include: National Library of Medicine. The Clinical Utility of Compounded Bioidentical Hormone Therapy: A Review of Safety, Effectiveness, and Use. Women may have facial hair or hair loss if there is too much pregnenolone in the body. This is because pregnenolone, the mother of all steroid hormones in our body, is a precursor to testosterone. Testosterone then is converted to DHT which causes hair loss. In Closing It does seem, however, that pregnenolone is less likely to have a masculinising effect in women than DHEA as it is less likely to increase testosterone levels. Pregnenolone dose

Regarding your link, it is common when cortisol rises that DHEA lowers but the cause is now thought to be other factors involving conversion rather than certain areas of diminished available pregnenolone (previously known as 'pregnenolone steal').

In one study men and women aged 40 to 70 years took 50 mg DHEA nightly for 3 months. This was found to double levels of androgens in women, but only produced a small rise in androstenedione in men. Treatment was associated with a marked increase in perceived physical and psychological well-being for both men (67%) and women (84%) but the volunteers reported no change in libido. As some DHEA is converted into oestrogen, there is a possibility of breast enlargement in men taking high doses long-term. In the brain, pregnenolone has a protective function. Fatigue can injure brain cells; pregnenolone supplement protects these cells from this kind of damage. Its calming effects can provide protection from the stress that leads to production of cortisol. While DHEA is freely available in some countries, it is beneficial is to consult a medical doctor who will measure your levels of DHEA/DHEAS (through either a blood or saliva test) to see if you need supplementation and, if so, determine the right dose. DHEA requirements vary from person to person. It is important not to take too much – smaller doses may be as effective and safer. When taking DHEA for low sex drive, it is usual to start with a low daily dose of 5 to 10 mg and to increase if this is ineffective, up to a dose range of 25 to 50 mg a day. Some physicians recommend smaller doses of 2 to 8 mg DHEA, taken every other day or, if taken daily, to stop them for a week or two after every month of treatment.Any of the above side effects will be worse when you take these supplements in high doses. If taken over a long period of time, withdrawal can be difficult. You may experience restlessness, high levels of anxiety, and nervousness. Some people report depression, fatigue, and even paranoia when stopping the supplement. The safest way of withdrawing from this supplement is to reduce your dosage by no more than 10mg per day. Kashani L, Shams N, Moazen-Zadeh E, et al. Pregnenolone as an adjunct to risperidone for the treatment of women with schizophrenia: A randomized double-blind placebo-controlled clinical trial. J Psychiatric Res. 2017;94:70-77. doi:10.1016/j.jpsychires.2017.06.011 DHEA (and the related hormone, pregnenolone, see below) are made in the body from cholesterol. If you are taking a cholesterol lowering medication (usually a statin) then this may suppress DHEA production. Benefits of a higher DHEA level Pregnenolone tests are blood tests conducted on infants, usually as part of a panel of tests. It is used as a diagnostic tool to help find the underlying cause of CAH in infants. CAH is suspected when an infant has ambiguous external sex organs, signs of adrenal insufficiency, excess loss of sodium and fluids, or low or high blood pressure. Purpose of the test Although reports of serious problems are infrequent, the long-term safety of using DHEA regularly for many years is unknown. Effects on risk of cancers for example – especially those of the prostate gland, thyroid, breast and ovaries – are not yet fully understood. Some doctors therefore advise those with a family history of hormone sensitive cancers not to take DHEA.

Key hormone levels decline as a result of the normal aging process, as can mental sharpness and memory function. Pregnenolone is the precursor to a whole family of hormones, including DHEA, testosterone, glucocorticoids, progesterone and estrogens. In addition to its ability to help maintain youthful hormone levels, pregnenolone also promotes youthful mental focus and cognitive function. With 17-alpha-hydroxylase deficiency, pregnenolone and progesterone may be elevated, along with 11-deoxycorticosterone. Other precursors and steroid hormones, if measured, may be low, including: DHEA levels rise during sex to reach levels that are three to five times higher than before. Exercise also increases DHEA levels temporarily but only if physical activity is consistent and sustained. You need to exercise vigorously for 30 minutes a day for one month before significant increases in DHEA levels occur. Maurya SW, Dev K, Shigh KB, et al. Synthesis and biological evaluation of heterocyclic analogues of pregnenolone as novel anti-osteoporotic agents. Bioorganic Med Chem Letters. 2017;27(6):1390-1396. doi:10.1016/j.bmcl.2017.02.004 Since pregnenolone and DHEA work in harmony, some physicians prescribe small amounts of each together. Some claim that this minimises the anabolic and oestrogenic effects of DHEA, although little research is available to confirm this.

Having a high DHEA level is linked with a higher sex drive, and falling levels of DHEA partly account for reduced sex drive with increasing age. The main medical use of DHEA is to replenish levels when sex drive dwindles in middle age. This wide range of unusual but not clinically problematic levels is called a subclinical state, and this is where those with AFS typically test. Adrenal Fatigue Syndrome (AFS) is a condition caused by chronic stress that is not well known among conventionally trained physicians. The symptoms of this condition are sometimes vague and difficult to recognize as a pattern that denotes a problem with adrenal output. However, these symptoms can become debilitating. On presenting symptoms of AFS to your physician, he or she will likely focus solely on the symptoms and not on a more comprehensive viewpoint in managing your condition. A pregnenolone supplement may be among the first things recommended, but it is important to consider what is going on with the hormones in the body and why before deciding if this is a good course of action. Conventional Medicine’s Approach to AFS This comprehensive blood test encompasses all of the necessary blood investigations required to make a preliminary diagnosis of testosterone deficiency. In addition to a full hormone panel, it also looks at other general health parameters to help identify any potential reversible causes of low testosterone, and give you a more complete picture of your overall health. The age-related reduction in DHEA levels appears to contribute to the increased risk of a number of age-related conditions such as diabetes, obesity, elevated cholesterol levels, heart disease, arthritis and autoimmune diseases. Some evidence suggests that replenishing DHEA levels helps to: