Since the microbiota-gut-brain axis has great interest from clinical doctors and scientific researchers, several meta-analyses have been conducted to conclude the effects of probiotics or prebiotics in improving depressive symptoms [ 18, 19, 65, 66]. Compared to previous studies, this meta-analysis has the following advantages. In terms of included participants, previous studies included healthy populations and comorbid depression patients (e.g., with comorbidity of IBS), which caused high heterogeneity within populations. Depression patients, therefore, could not acquire helpful guidance on whether they should choose microbiota management agents. This study only included depression patients without major comorbidities to make a valid and generalized conclusion for patients with depression. Second, no previous meta-analysis has comprehensively examined and compared the effects of prebiotics, probiotics, and synbiotics on depression. Alli et al. conducted a systematic review on the benefits of prebiotics, probiotics and synbiotics to depressive patients, but it did not include a quantitative meta-analysis, which was exhibited in our study [ 20]. With regard to the outcomes, not only were the improvements in depressive symptoms evaluated, but gut microbiota indices and inflammatory indicators were also compared between the intervention and placebo groups. Finally, the data in our study were very recent, as 10 of 13 included studies were published between 2019 and 2022 and were not included in the previous meta-analyses. It is clinically tested and proven to promote health and function of the digestive tract as well as helping to boost immune function. It also promotes better digestion and nutrient absorption means you get more energy from the food you eat. Enam F, Mansell TJ (2019) Prebiotics: tools to manipulate the gut microbiome and metabolome. J Ind Microbiol Biotechnol 46:1445–1459

The first of its kind, the DS-01™ includes clinically and scientifically studied probiotic strains that deliver core benefits to the gastrointestinal system which, in turn, influence systemic health. It also has benefits for improving your gut function, skin health, heart health, and immune function.Pineiro M, etal. (2008). "FAO Technical Meeting on Prebiotics. Food and Agricultural Organization of the United Nations. 2007". J Clin Gastroenterol. 42 Suppl 3 Pt 2: S156–9. doi: 10.1097/MCG.0b013e31817f184e. PMID 18685504. Two reviewers independently extracted the data from the included articles, and any conflicts were resolved by discussion with the corresponding author. The following data were extracted: (1) basic information of studies including first author, publication year, country, and study design; (2) population characteristics including clinical diagnosis of depression, diagnostic criteria, duration of depression, age, sex, body mass index (BMI), education; (3) intervention characteristics including the types of intervention (prebiotics, probiotics or synbiotics), probiotic strains, dosage, intervention duration, usage of antidepressant drugs; (4) the change in rating scales for depression, depression-related biomedical indicators, microbiome taxa, α and β diversity (α diversity represents the richness and evenness of the microbial community in individual samples, while β diversity evaluates interindividual diversity that assesses dissimilarity of microbial communities compared with the other samples analyzed). Quality assessment Probiotics are beneficial bacteria that can help to re-establish the normal microbiota. They are particularly effective when delivered together with a prebiotic, a source of nutrition that stimulates growth. The prebiotic PreforPro® helps target undesirable gut bacteria and allows healthy probiotic bacteria to have more room to flourish and take advantage of helpful nutrients in both the small and large intestines. While the postbiotic Corbiome® Tributyrin fuels the cells that make up the gut lining, supports gut barrier function, and keeps the intestinal gut flora healthy.

Synbiotic D-C has a 2 year shelf life from the date of manufacture. Store in a cool dry place. FAQs Rudzki L, et al. Probiotic Lactobacillus Plantarum 299v decreases kynurenine concentration and improves cognitive functions in patients with major depression: a double-blind, randomized, placebo controlled study. Psychoneuroendocrinology. 2019;100:213–22.Its proprietary blend contains 16 probiotic strains including, but not limited to Lactiplanti Bacillus plantarum SD-LP1-IT, Lactobacillus rhamnosus SD-LR6-IT, Bifidobacterium lactis SD-BS5-IT, Bifidobacterium lactis SD150-BE, Limos Lactobacillus fermentum SD-LF8-IT, Limos Lactobacillus reuteri RD830-FR. The prebiotic component comes from Indian pomegranate. Reininghaus EZ, et al. PROVIT: supplementary probiotic treatment and vitamin B7 in depression-a randomized controlled trial. Nutrients. 2020;12(11):3422. Sergeev IN, Aljutaily T, Walton G, Huarte E (2020) Effects of symbiotic supplement on human gut microbiota, body composition and weight loss in obesity. Nutrients 12:222