CBS president Frank Stanton felt that the presentation artwork was too scary for young viewers and, thinking the show would be the same, decided to pass on it. Jaffe was later replaced by Pat Stevens, who would voice Velma from 1976 to 1979; Marla Frumkin replaced her from 1979-1980 and would voice the character again in 1984.

Weerd comes up with a scheme to lure Shaggy and Scooby to open the Chest of Demons so he and Bogel can gain some glory with the 13 ghosts. team, inviting them all to the theme park where he was conducting the ritual after they broke up years before simply to make them witness his triumph when he only needed Scooby present, intending to use Scooby's 'pure' soul to complete his ritual. In nearly every episode, Weerd and Bogel attempt to help out one of the chest escapees in fulfilling their master plan. They also help the gang find another clue of the Crystal Cove Mystery, by discovering and deciphering a hidden soundtrack in the Planispheric Disk. A Pup Named Scooby-Doo was developed and produced by Tom Ruegger, who had been the head story editor on Scooby-Doo since 1983.Scooby-Doo has maintained a significant fan base, which has grown steadily since the 1990s due to the show's popularity among both young children and nostalgic adults who grew up with the series. She occasionally helps the rest of the gang capture the villain by using some random, yet helpful, accessories she has at the moment.

Hanna-Barbera musical director Hoyt Curtin composed a new theme song for this series, and Curtin's theme remained in use for much of Scooby-Doo's original broadcast run.

Pericles becomes more depraved as the series draws to its close as he works to free his "master", the Evil Entity, in hopes of becoming all-powerful in exchange for releasing the Entity. When Scrappy-Doo was introduced to the series in 1979, he, Scooby, and Shaggy became the foci of much of the merchandising, including a 1983 Milton-Bradley Scooby-Doo and Scrappy-Doo board game. In The 13 Ghosts of Scooby-Doo, she wore some other purple clothes with purple pants and purple high heels. Writing in 2020, Christopher Orr of The Atlantic queried why the franchise had remained popular for several decades, concluding that it was primarily due to the many differing ways in which the relationship between the main characters could be interpreted or used as a metaphor.