Genazzani AD, Lanzoni C et al. Myo-inositol administration positively affects hyperinsulinemia and hormonal parameters in overweight patients with polycystic ovary syndrome. Gynecol Endocrinol. 2008 Mar;24(3):139-44.
15. Minozzi M, Costantino D et al. The effect of a combination therapy with myo-inositol and a combined oral contraceptive pill versus a combined oral contraceptive pill alone on metabolic, endocrine, and clinical parameters in polycystic ovary syndrome. Gynecol Endocrinol. 2011 Nov;27(11):920-4. PCOS is a syndrome that occurs when a woman’s body produces abnormally high amounts of certain hormones. Jamilian M, Farhat P, Foroozanfard F, Afshar Ebrahimi F, Aghadavod E, Bahmani F, et al. Comparison of myo-inositol and metformin on clinical, metabolic and genetic parameters in polycystic ovary syndrome: a randomized controlled clinical trial. Clin Endocrinol. 2017;87(2):194–200. Rizzo P, Raffone E, Benedetto V. Effect of the treatment with myo-inositol plus folic acid plus melatonin in comparison with a treatment with myo-inositol plus folic acid on oocyte quality and pregnancy outcome in IVF cycles. A prospective, clinical trial. Eur Rev Med Pharmacol Sci. 2010 Jun;14(6):555-61.
19. Papaleo E, Unfer V, et al. Myo-inositol may improve oocyte quality in intracytoplasmic sperm injection cycles. A prospective, controlled, randomized trial. Fertil Steril. 2009 May;91(5):1750-4. Another study in 20 overweight women with PCOS found that 12 weeks of supplementation with myo-inositol improved insulin sensitivity and reproductive hormone balance and completely restored the menstrual cycle in all amenorrheic and oligomenorrheic subjects. 14

No significant differences were found between the inositol and the metformin treatment regarding the investigated glycemic outcomes, suggesting non-inferiority of inositols to metformin (Figure S 9- 13b.). Pregnancy in PCOS A, Arslan S, Kocaadam B, Elibol E, İmamoğlu İ, Karadağ MG Effect of inositol and its derivatives on diabetes: a systematic review. Crit Rev Food Sci Nutr. (2019)Myo-inositol is one supplement in particular which has received widespread attention for the potential role it has to play in supporting women with PCOS. And much research to date indicates that this novel supplement has the potential to provide support for many of these key areas. Compared to placebo, inositols significantly reduced total testosterone levels (MD = -20.39 ng/dl, CI: -40.12; -0.66, Figure S 3a.). Two studies showed an advantageous effect of DCI for this outcome. On the other hand, free testosterone was significantly reduced by inositol treatment compared to placebo (MD = -0.41 ng/dl, CI: -0.69; -0.13, Figure S 4.). SHBG levels were significantly increased by inositols (MD = 32.06 nmol/l, CI: 1.27; 62.85, Figure S 5a.). Androstenedione was also significantly reduced after inositol treatment (MD = -0.69 ng/ml, CI: -1.16; -0.22, Figure S 6.). Myoinositol, compared to placebo, also seems to have a beneficial effect on androstenedione (MD = 0.89 ng/ml, CI: -1.56; -0.22, Figure S 6.). DCI reduced DHEAS levels (MD = -168.48 μg/dl, CI-281.15; -55.82, Figure S7a.). However, the combined analysis of different inositols did not reach the level of significance. Finally, only one study investigated the effect of inositol on the FG-score [ 15]. Needless to say, polycystic ovary syndrome is complex, commonly difficult to diagnose and is often missed completely. 4,5

Simonet BM, Ríos A, Grases F, Valcárcel M Determination of myo-inositol phosphates in food samples by flow injection-capillary zone electrophoresis. Electrophoresis. (2003-Jun) Kofman O, Einat H, Cohen H, Tenne H, Shoshana C The anxiolytic effect of chronic inositol depends on the baseline level of anxiety. J Neural Transm (Vienna). (2000)Jamilian H, Jamilian M et al. Comparison of myo-inositol and metformin on mental health parameters and biomarkers of oxidative stress in women with polycystic ovary syndrome: a randomised, double-blind, placebo-controlled trial. J Psychosom Obstet Gynaecol. 2018 Dec; 39(4): 307-314 Over 20 nutrients to support your reproductive health and fertility. Each vitamin and mineral has been nutritionally formulated to nourish your body in preparation for a healthy pregnancy. Take 2 tablets in the morning and 2 tablets in the evening. We recommend using this supplement consistently for 90 days. Do not exceed the recommended daily intake. Studies have found that inositol may be beneficial for improving the function of the ovaries and fertility in women with PCOS ( 16, 17, 18).