Firstly, thank you for the work you’ve done on informing the world about Thiamine and its derivatives. Your work is outstanding and has clearly helped countless people. Not only that, your work is clearly pushing a wave forward of new “medicine” that comes from nature and is focused on true healing, not fixing symptoms. So my question is, does this sound like thiamine deficiency that started a long time ago to you? What would be your recommendations in this case in terms of taking the Alithiamine. Should I increase dose? Should I try to lower the dose? Should I be able to reach a point of not having to rely on the supplement in the future?

Thank you for your reply and advice. This particular doctor is a top Nephrologist here in NY and he’s also been a close friend since I was in my teens so there were a few advantages talking to him on the subject. In terms of alcohol consumption, about a year ago, for the first time in my life, I start chronic drinking. I stopped for 3 months after the Papilledema diagnosis, but then about 3.5 weeks ago started again, this time consuming much less alcohol. Around 2 weeks ago is when I noticed the memory and balance issue. I have stopped drinking again. At the moment I can only manage oral supplementation every 5 or more days without getting worsening stomach pains. This has taken the edge off the worst of my symptoms but is not really enough to replete me I suspect. I don’t know how to proceed. I am in the UK and cant source all forms of B1 that have been mentioned. I have Benfothiamine and the HCl form. When you mention starting with very small doses what sort of doses do you mean? Also what are the typical adverse symptoms? Would my gut pain be one such symptom? I do get similar gut pain from other supplements and many foods so it is not only B1 that causes it. I have Hashimoto’s and have not felt well under all the different meds I’ve tried over the past 5 years. I believe my condition is due to B1 deficiency, and the symptoms are getting more severe now that I’m 52. I eat a pretty basic diet of lean animal protein, vegetables and fruits, olive and coconut oil, with occasional sprouted grain and cheddar cheese, 2-3 liters of water per day with LMNT electrolytes. I began to pay more attention to my nutrition and supplements which included the water soluable vitamins, but I was not consistent with either.

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I have weak, heavy muscles, edema and can’t walk more than 50 feet without resting or else my body feels like heavy jelly. Last time I had this issue in 2015 I tested very high for urinary loss of Phosphorus and Potassium. My Nephrologist thought I had kidney damage from a toxin but he also thought it could be the massive amounts of supplements I was taking for the Refeeding Syndrome. This time around my urine was not tested.

I’v not been taking Lipothiamine for a little over a month. I believe the main symptoms of “paradox” have resolved which were emotional volatility, extra physical anxiety and chest pains. I have now increased the dosage to 200mg lipothiamine per day split in the following manner: 100mg at breakfast, 50mg at lunch, 50mg at dinner. Pyridoxine induced cell death in a concentration-dependent way in SHSY5Y cells. The other vitamers did not affect cell viability. […] “Moreover, both pyridoxal-5-phosphate dependent enzymes were inhibited by pyridoxine. In conclusion, the present study indicates that the neuropathy observed after taking a relatively high dose of vitamin B6 supplements is due to pyridoxine. The inactive form pyridoxine competitively inhibits the active pyridoxal-5′-phosphate. Consequently, symptoms of vitamin B6 supplementation are similar to those of vitamin B6 deficiency.” In fact it was upping the carbs that caused the nausea, loss of appetite, apathy and cognition problems. I stumbled across an article about B1 and it seemed to fit. Should one refrain from taking TTFD supplements in the evening. Are they known to interfere with sleep? Bayan L., Koulivand P.H., Gorji A. Garlic: A review of potential therapeutic effects. Avicenna J. Phytomed. 2014;4:1–14.Diabetes mellitus-related morbidity and mortality is a rapidly growing healthcare problem, globally. Several nutraceuticals exhibit potency to target the pathogenesis of diabetes mellitus. The antidiabetic effects of compounds of garlic have been extensively studied, however, limited data are available on the biological effects of a certain garlic component, allithiamine. In this study, allithiamine was tested using human umbilical cord vein endothelial cells (HUVECs) as a hyperglycaemic model. HUVECs were isolated by enzymatic digestion and characterized by flow cytometric analysis using antibodies against specific marker proteins including CD31, CD45, CD54, and CD106. The non-cytotoxic concentration of allithiamine was determined based on MTT, apoptosis, and necrosis assays. Subsequently, cells were divided into three groups: incubating with M199 medium as the control; or with 30 mMol/L glucose; or with 30 mMol/L glucose plus allithiamine. The effect of allithiamine on the levels of advanced glycation end-products (AGEs), activation of NF-κB, release of pro-inflammatory cytokines including IL-6, IL-8, and TNF-α, and H 2O 2-induced oxidative stress was investigated. We found that in the hyperglycaemia-induced increase in the level of AGEs, pro-inflammatory changes were significantly suppressed by allithiamine. However, allithiamine could not enhance the activity of transketolase, but it exerts a potent antioxidant effect. Collectively, our data suggest that allithiamine could alleviate the hyperglycaemia-induced endothelial dysfunction due to its potent antioxidant and anti-inflammatory effect by a mechanism unrelated to the transketolase activity. I tried to go up to 150mg a few days ago – with the last 50mg dose at dinner – but that seemed to correlate with an increase in anxiety and insomnia. I cannot say whether this connection is real, as it could be the normal vicissitudes of my anxiety – but it has been severe. I’ve just worked up over 5 weeks to 50mgs of allithiamine and am really struggling. Sleep disturbed again, leg/nerve pain increasing, digestion off and my heart rate was so high on a little walk today I nearly passed out. Is this paradox? I’m very concerned about the level of potassium I need and would really appreciate your words of wisdom/advice as I feel in a real mess with my health and am having a repeat ECG on Monday I just hope my t wave is normal again. I’ve not been able to work since March and feel quite desperate. Should I still take your recommended dose of 100-200mg Lipothiamine in addition to Magnesium Taurate or would the dose now be different? How much magnesium taurate–and when/how often? [He’s been taking magnesium citrate gummies very well for about a week, so if mag citrate is an acceptable option, that would be helpful.]