Bruin JE, Gerstein HC, Holloway AC (August 2010). "Long-term consequences of fetal and neonatal nicotine exposure: a critical review". Toxicological Sciences. 116 (2): 364–74. doi: 10.1093/toxsci/kfq103. PMC 2905398. PMID 20363831. there is no safe dose of nicotine during pregnancy... The general consensus among clinicians is that more information is needed about the risks of NRT use during pregnancy before well-informed definitive recommendations can be made to pregnant women... Overall, the evidence provided in this review overwhelmingly indicates that nicotine should no longer be considered the safe component of cigarette smoke. In fact, many of the adverse postnatal health outcomes associated with maternal smoking during pregnancy may be attributable, at least in part, to nicotine alone. Possible alteration of nicotine absorption through the skin from the transdermal nicotine patch by drugs that cause vasodilation or vasoconstriction. [75]

After countless prototypes, ELFBAR has developed a range of world-class products manufactured with high-quality materials and designs that resonate with vapers. Sarter M (August 2015). "Behavioral-Cognitive Targets for Cholinergic Enhancement". Current Opinion in Behavioral Sciences. 4: 22–26. doi: 10.1016/j.cobeha.2015.01.004. PMC 5466806. PMID 28607947. Vaping is a relatively recent invention, and so little research has looked into its short- and long-term effects. Researchers do not yet know whether the body processes nicotine differently from cigarettes or vapes.a b c d e Royal College of Physicians (28 April 2016). "Nicotine without smoke: Tobacco harm reduction" . Retrieved 16 September 2020. a b c d e f g Parrott AC (April 2003). "Cigarette-derived nicotine is not a medicine". The World Journal of Biological Psychiatry. 4 (2): 49–55. doi: 10.3109/15622970309167951. PMID 12692774. S2CID 26903942.

Elf Bar Zero Blue Razz: Dive into a sea of electrifying flavor with Blue Razz. Each puff is a burst of tangy and sweet blue raspberry goodness that will leave your taste buds tingling. a b c El Sayed KA, Sylvester PW (June 2007). "Biocatalytic and semisynthetic studies of the anticancer tobacco cembranoids". Expert Opinion on Investigational Drugs. 16 (6): 877–87. doi: 10.1517/13543784.16.6.877. PMID 17501699. S2CID 21302112. Mishra A, Chaturvedi P, Datta S, Sinukumar S, Joshi P, Garg A. Harmful effects of nicotine. Indian J Med Paediatr Oncol. 2015;36(1):24-31. doi:10.4103/0971-5851.151771Australian Bureau of Statistics. Pandemic insights into Australian smokers, 2020-212021 [cited: 16.11.2022]. If you notice any Elf Bar vape UK retailers offering products that exceed these limits, be extremely careful. Either you’ll be purchasing vape products from a retailer who shows complete disregard for vaping regulation, or even worse the Elf Bars you’ll be buying are fake. Either way, avoid them like the plague! Normal between-cigarettes discontinuation, in unrestricted smokers, causes mild but measurable nicotine withdrawal symptoms. [33] These include mildly worse mood, stress, anxiety, cognition, and sleep, all of which briefly return to normal with the next cigarette. [33] Smokers have a worse mood than they typically would have if they were not nicotine-dependent; they experience normal moods only immediately after smoking. [33] Nicotine dependence is associated with poor sleep quality and shorter sleep duration among smokers. [96] [97]

Audrain-McGovern J, Benowitz NL. Cigarette smoking, nicotine, and body weight. Clin Pharmacol Ther. 2011;90(1):164-168. doi:10.1038/clpt.2011.105 Caponnetto P, Campagna D, Papale G, Russo C, Polosa R (February 2012). "The emerging phenomenon of electronic cigarettes". Expert Review of Respiratory Medicine. 6 (1): 63–74. doi: 10.1586/ers.11.92. PMID 22283580. S2CID 207223131. Since 2018, ELFBAR has been making innovative products that utilise a smart heating system. In tandem with a passion for invention, ELFBAR has developed a collection of popular vape devices with a wide choice of flavours. The estimated lower dose limit for fatal outcomes is 500–1,000mg of ingested nicotine for an adult (6.5–13mg/kg). [25] [27] Nicotine addiction involves drug-reinforced behavior, compulsive use, and relapse following abstinence. [28] Nicotine dependence involves tolerance, sensitization, [29] physical dependence, psychological dependence, [30] and can cause distress. [31] [32] Nicotine withdrawal symptoms include depressed mood, stress, anxiety, irritability, difficulty concentrating, and sleep disturbances. [1] Mild nicotine withdrawal symptoms are measurable in unrestricted smokers, who experience normal moods only as their blood nicotine levels peak, with each cigarette. [33] On quitting, withdrawal symptoms worsen sharply, then gradually improve to a normal state. [33]Spasova V, Mehmood S, Minhas A, et al. Impact of nicotine on cognition in patients with schizophrenia: A narrative review. Cureus. 2022;14(4):e24306. doi:10.7759/cureus.24306 Some people believe that smoking ‘light’ or ‘low tar’ cigarettes is less harmful than regular cigarettes. However, there is little difference between the amount of chemicals inhaled by people who smoke ‘light’ cigarettes and those who smoke regular ones. 4 Long-term effects Nicotine: Clinical data". IUPHAR/BPS Guide to Pharmacology. International Union of Basic and Clinical Pharmacology . Retrieved 28 November 2023. Used as an aid to smoking cessation and for the relief of nicotine withdrawal symptoms.