If you take more SMECTA 3 g ORANGE-VANILLA, powder for oral suspension in sachet you should not have Smecta should not be taken while taking other medications. Because the ingredients in the drug may be resistant to ingredients of other drugs. If you use other drugs or over the counter products at the same time, the effects of Smecta Sachet Powder may change. This may increase your risk for side-effects or cause your drug not to work properly. Tell your doctor about all the drugs, vitamins, and herbal supplements you are using, so that you doctor can help you prevent or manage drug interactions. Smecta Sachet Powder may interact with the following drugs and products: The statistical analysis plan was based upon the assumption that the duration of the diarrhoea episode would be shorter than seven days for all patients, without any risk of data censure. It was therefore planned to compare mean diarrhoea durations using the Wilcoxon's test, which is perfectly adapted to this type of data. The definition of diarrhoea duration required that patients are followed after the first formed stool to confirm the end of the diarrhoea episode. This definition of recovery was selected to guarantee the clinical relevance of the primary criterion. Of note is that it was much more constraining than previous trials, which defined recovery as the first nonliquid stool. However, according to the definition of recovery used in the study, 35 patients showed diarrhoea duration longer than seven days. Since the protocol planned a seven-day followup, these patients were censored in statistical analyses. Nevertheless, a post hoc time to event analysis taking data censure into account was carried out. The Gehan-Wilcoxon test was preferred to the Logrank test because of the particular distribution of the events considered and the onset of censures during study followup. Indeed, the Gehan-Wilcoxon test is more adapted than the Logrank test to early events and late censures. Moreover the latter is based upon the assumption of proportional hazards, which is most probably not verified in this trial since the active treatment is supposed to shorten time to recovery without modifying the risk of recovery. Acute watery diarrhoea is self-resolving, even in the absence of treatment. The results of the Gehan-Wilcoxon test confirmed the effectiveness of diosmectite. These results are consistent with the primary analysis and confirm that diosmectite shortens time to recovery.

In the ITT population ( n = 329), the median [range] time to recovery was significantly shorter in the diosmectite group (53.8 hours [3.7–167.3]) than in the placebo group (69.0 hours [2.0–165.2]) when tested with Wilcoxon's test ( P = .0294). The difference between the two groups was 15.2 hours. The statistical significance of this effect was also evidenced by the post hoc analysis using the time-to-event Gehan-Wilcoxon test considering censored data: 56.3 hours [47.7– 68.0] in the diosmectite group versus 72.2 [63.3– 82.0] hours in the placebo group ( P = .0291). Proper storage of Smecta sachet is essential to maintain its effectiveness. Here are some storage guidelines: Smecta sachet is a medicinal marvel that contains Diosmectite as its active ingredient. Diosmectite is a natural clay-like substance that has remarkable adsorbent properties. This means that it can bind to harmful substances in the gastrointestinal tract, helping to alleviate diarrhea. How Does Smecta Work?The following is a list of possible side-effects that may occur from all constituting ingredients of Smecta Sachet Powder. This is not a comprehensive list. These side-effects are possible, but do not always occur. Some of the side-effects may be rare but serious. Consult your doctor if you observe any of the following side-effects, especially if they do not go away.

In children and infants, acute diarrhea should be treated in combination with the early administration of oral rehydration solution (ORS) to prevent dehydration. Do not use this medication for long periods of time without the advice of your doctor: tests may be necessary if symptoms persist. It is used in the symptomatic treatment of acute diarrhea, in addition to dietary measures, chronic diarrhea and pain in the esophagus, stomach, duodenum or colon.

Smecta Digestive Dressing is indicated for the symptomatic treatment of acute diarrhea in children and infants in addition to oral rehydration and in adults.