Rottembourg JB, Launay-Vacher V, Massard J. Thrombocytopenia induced by nicotinamide in hemodialysis patients. Kidney Int. 2005;68(6):2911-2. View abstract. Diabetes. Taking niacinamide by mouth might help slow the progression of type 1 diabetes. But it doesn't seem to prevent diabetes. Nicotinamide, available in a topical cream, gel and oral forms (eg, Nicomide®), has been shown to be effective in clearing acne. In a controlled clinical trial, 4% nicotinamide gel was found to be as effective as the topical antibiotic 1% clindamycin gel in the treatment of acne vulgaris in 76 patients with moderate acne. The study concluded that the anti-inflammatory properties of nicotinamide might have contributed to its success in acne. Zhang Y, Ma T, Zhang P. Efficacy and safety of nicotinamide on phosphorus metabolism in hemodialysis patients. Medicine (Baltimore). 2018;97(41):e12731. doi:10.1097/MD.0000000000012731. In supplements, niacinamide might be listed on the label in niacin equivalents (NE). 1 mg of niacinamide is the same as 1 mg NE. Niacinamide is found in many vitamin B complex supplements with other B vitamins. It's also used in many topical creams and gels.

Vitamin B3 Nicotinamide (Niacinamide) 500mg | Health4All Vitamin B3 Nicotinamide (Niacinamide) 500mg | Health4All

Phosphate levels are otherwise typically managed through diet, medications or dialysis, depending on the severity of the buildup ( 20). May Slow the Progression of Type 1 Diabetes

El-Khalawany M, Nouh AH, Kadah AS, Elsheikh M, Said M. Evaluation of safety and efficacy of topical 4% nicotinamide in treatment of psoriasis; among a representative sample of Egyptians (an analytical observational study). Dermatol Ther 2022;35(9):e15734. View abstract. When applied topically or taken orally as a supplement, niacinamide has been shown to have anti-inflammatory effects on the skin ( 5). Hoskin PJ, Rojas AM, Phillips H, Saunders MI. Acute and late morbidity in the treatment of advanced bladder carcinoma with accelerated radiotherapy, carbogen, and nicotinamide. Cancer. 2005;103(11):2287-97. View abstract. Know what else is in your supplements before taking them. Niacinamide supplements, including oral (by mouth) capsules and topical (skin) serums, often contain other ingredients.

Nicotinamide | Drugs | BNF | NICE

Nijkamp MM, Span PN, Terhaard CH, Doornaert PA, Langendijk JA, van den Ende PL, de Jong M, van der Kogel AJ, Bussink J, Kaanders JH. Epidermal growth factor receptor expression in laryngeal cancer predicts the effect of hypoxia modification as an additive to accelerated radiotherapy in a randomised controlled trial. Eur J Cancer. 2013 Oct;49(15):3202-9. View abstract. Omidian M, Khazanee A, Yaghoobi R, Ghorbani AR, Pazyar N, Beladimousavi SS, Ghadimi M, Mohebbipour A, Feily A. Therapeutic effect of oral nicotinamide on refractory uremic pruritus: a randomized, double-blind study. Saudi J Kidney Dis Transpl. 2013 Sep;24(5):995-9. View abstract. Vitamin B3 is essential for good health; deficiency leads to a serious illness, pellagra. Oral nicotinamide can be used effectively to treat pellagra. Liver and gallbladder issues: People with liver or gallbladder disease should take special precautions when taking niacinamide. Niacinamide may worsen symptoms in these populations.

Topical nicotinamide

Nicotinic acid and niacinamide can both treat pellagra, but niacinamide is preferred since it’s associated with fewer side effects, such as flushing of the skin. Summary Swash M, Roberts AH. Reversible pellagra-like encephalopathy with ethionamide and cycloserine. Tubercle 1972;53:132. View abstract. Greenbaum CJ, Kahn SE, Palmer JP. Nicotinamide's effects on glucose metabolism in subjects at risk for IDDM. Diabetes 1996;45:1631-4. View abstract.