We aimed to recruit 1200 male participants as a part of an infertile couple, based on the following data and power calculation. CoQ10 is found directly in the follicular fluid surrounding an egg and is an anti-oxidant. It works directly inside the mitochondria of cells to energise its internal biological processes. Also known as Ubiquinol it is used in IVF to try and increase egg number and quality. Time to pregnancy defined as (1) the time between randomisation and reaching ongoing pregnancy (confirmed by ultrasound) and (2) the time between start of fertility treatment during the study (EM, IUI and IVF/ICSI) and reaching ongoing pregnancy.

The remarkable effectiveness of the antioxidant activation on the one hand and the respect for the metabolic physiology on the other, make Impryl the ideal support for reproduction. Gametogenesis is, among the physiological functions, the most sensitive to a perfect metabolic balance. This is currently defined as pre-conceptional support, i.e. a supplementation of both partners from at least three months before conception. The positive effects will concern not only the chances of conceiving but also the probability of having a serene pregnancy and a healthy baby. For comprehensive information see the preconception care advices from the World Health Organization (WHO).

Fortunately, there are actions you can take to improve male fertility, including introducing male fertility supplements to your diet. How to boost male fertility and sperm count Cysteine donor ( cystine) to compensate for a possible defect of the enzyme CBS (cystathionine beta synthetase) The combined effect of the micronutrients of Impryl is a boost to methylations, which are necessary for key biochemical syntheses including DNA, RNA and key substances like CoQ10 and carnitine and for the process of DNA methylation as part of the epigenetic programming. The increased methylations also result in a strong boost to the endogenous release of glutathione (GSH), a key physiologic antioxidant. All couples will receive our standard care for infertility according to the guidelines of the Dutch Society of Obstetrics and Gynaecology. After diagnostic workup, couples will either start with EM (6 months), IUI, IVF or ICSI. Participants will take study supplement for a maximum of 6 months, even if the fertility intervention (6× IUI of 1× IVF/ICSI cycles) is not completed.

Coast Science® MFSg5 has a proprietary blend of powerful ingredients formulated to optimise the critical factors of sperm count, motility, morphology, and overall integrity. Impryl is the first antioxidant dietary supplement based on a well defined mechanism of action: indirect antioxidant activity by means of the modulation of the enzyme CBS that regulates the synthesis of glutathione (GSH), the primary cellular antioxidant. If you have PCOS you probably have a better chance of absorbing myo-inositol into the body when taking this combination. It also includes the essential folic-acid required to reduce neural tubal defects in developing babies. Clinical data from multiple studies proves that men suffering from fertility problems are twice as likely to have a baby when taking the active micronutrients in Impryl.

Acknowledgments

The consultant recommended to my husband that he take Impryl and we keep trying. He was a bit dubious but thought, why not. There must be a certain degree of probability that the event is a harmful and an undesirable reaction to the medicinal product under investigation, regardless of the administered dose. The only reason I found out I was pregnant because on day 3 I stopped bleeding…but I carried on having cramps! Any other important medical event that did not result in any of the outcomes listed previously due to medical or surgical intervention but could have been based on appropriate judgement by the investigator. Anyone looking to improve egg number and quality but particularly those with a diminished ovarian reserve and/or poor embryo development. Consider taking 200mg daily for 10-14 days and then reducing to 100mg daily. Take CoQ10 for at 2 months before egg collection.

Inofolic Alpha is a dietary supplement designed for women with PCOS. Inofolic Alpha contains myo-inositol, alpha-lactalbumin and folic acid. The remaining SUSARs are recorded in an overview list (line listing) that will be submitted once every half year to the METC. This line listing provides an overview of all SUSARs from the study medicine, accompanied by a brief report highlighting the main points of concern. The expedited reporting of SUSARs through the web portal Eudravigilance or ToetsingOnline is sufficient as notification to the competent authority.No significant side effects or negative interactions with other medicines have been found with MFSG5. Standard sperm tests focus on quantity, motility and morphology but do not test for DNA fragmentation. At the appointment we were given a leaflet and recommendation to take Impryl which initially we dismissed as just another tablet to take. However, after taking for 1 MONTH (honestly true!) my wife and I are pregnant and awaiting our 12 week scan in a few weeks. Its formula contains all the substances required for the activation of antioxidant defenses in the absence of any substance with direct antioxidant activity. Moreover, it supplies the substances capable of compensating for the possible presence of the most common pathological variants of metabolic enzymes, in particular:

Put simply, this means supporting the body’s metabolism to ensure it is in the optimal state possible for producing sperm – and the sperm that is produced is of the best possible quality. It also supports the production of good quality eggs in women. Anyway, fast forward to August 2023. He has been taking Impryl for 4 months. He had a repeat analysis on Monday and I wasn’t expecting much. These were the results. For anyone who doesn’t know the tablets are usually given to people who are going on holiday but don’t want a period so the tablet delays the period but after stopping them you have a ‘withdrawal bleed’.

Competing interests The study is conducted by the department of gynaecology and obstetrics of the Radboudumc. As stated above in the funding section, an unrestricted grant from Goodlife Pharma B.V. was provided for the conduct of the trial.