The film gives a pseudoscientific explanation as to how Love Potion No. 8 "works." It is explained: BlurtFeed • Camp Flabanabba • Curse Purge Plus! • Fancy Eats • Garage • Haas & Milan • Harry Herpson High School • Israel • Mega Gargantuan Republic • Morty's Room • Needful Things • Shoney's • Smith Residence • St. Equis Hospital • Summer's Room • Titanic 2 • Wholesome Delight • Yard Grace pushes Jessica to do things to make her popular; she cares a great deal about how the rest of the school sees her and Jessica. She does not appear to be a good influence on Jessica, as she convinces Jessica to act differently solely so people will look up to and like her. Jessica likes her because she thinks she has good advice and she looks at the girl as someone from whom she can seek guidance. In reality, Jessica doesn't care about being popular: she only acts the way she does because her friend encourages her to do so. In the episode " The Whirly Dirly Conspiracy", it is revealed that Morty is so infatuated with Jessica that he believes they will one day have at least one child together and that, should they have a daughter, she will be very attractive due to Jessica's genes.

Jerry's armored car is a reference to the armored parking shuttles in the final act of the film, Dawn of the Dead. In the after credits scene, Summer is performing, somewhat inaccurately, Quint's U.S.S. Indianapolis speech from the movie Jaws. Conroy • Delivery Drone • Donna Guterman • Gwendolyn • Heistotron • Lady Katana • Pat Guterman • Purpose Robot • Space Cruiser • The Garage Potions that have been merely created from an initial Awkward Potion must be consumed therefore they can only have an effect on players - they cannot be considered combat weapons. For example, if the player has a Potion of Harming, all they can do is consume it, which would be impractical as it would only deal damage to them.Beth: Loving you is work, Jerry. Hard work. Like building a homeless shelter. Nobody wants to say no to doing it, but some people put the work in. So what do you say? Do you see me working here? Does this conversation seem tedious to me? When Jerry tells to his son Morty the story about how he fell in true love, he "Fell in love with a young woman named 'Your Mom', and that's not an urban diss." This was a reference to what's known as Maternal Insults, a popular way of jokingly insulting people that kids do nowadays, wherein they will respond to questions people ask them by saying "Your Mom!" or randomly add that into their sentences as a way to offend them.

The Blu-Ray release features special guest commentary from Simpsons Crew Matt Groening, Al Jean, J. Stewart Burns, Max Pross, Matt Selman, Jon Kern, and Tom Gammill C • 304-X • 9-2184C • C-131 • C-132 • C-137 • C-500A • C-1239 • C-4499 • J19α7 • J19ζ7 • Blender Dimension • Blumbus Dimension • Buttworld • Corn Universe • Cromulon Dimension • Cronenberg World • Cronenberged dimension • Dog Dimension • Doopidoo Dimension • Fantasy World • Fascist dimension • Fascist Dystopian Universe • Fourth Dimension • Froopyland • Furniture Universe • Greasy Grandma World • Hamster in Butt World • Hell • Meta Reality • Merged Universe • Narnia Dimension • Parmesan dimension • Pantless Universe • Phone Universe • Pizza Universe • Post-Apocalyptic Dimension • Reverse Height Universe • Shrimp Universe • Teddy Universe • Toilet Dimension • Tusk Dimension • Wasp Universe Jerry: God? God's turning people into insect monsters, Beth. I'm the one beating them to death. Thank me. Whether or not it’s given the proper context, this is one of the bleakest quotes from the entire series. But rather than a source of despair, this epiphany is meant to inspire a kind of radical acceptance that we can’t control the chaos of the universe, so we might as well accept it, relax, and not let the horrors of existence destroy us.

Splash Potions, on the other hand, can be used against enemies if thrown at them, and that is what makes them so useful in combat. This means that a Splash Potion of Harming would actually deal damage to whoever it's thrown at it. At first, potions might not seem like the most useful offensive weapons, but if used correctly and strategically they can greatly impact on well a player does in a fight, and this might be crucial when facing threatening bosses such as the Wither for example.