The most comprehensive review and history of jet injection to date is published in the 6th edition of the textbook Vaccines. is a top plan view of the target area of the gel target, a side cross-sectional view through the gel target and a graph showing the penetration depth variation with position after the firing at the gel target of particles from the needleless syringe shown in FIG. A61M5/00— Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e. Even if the product is trending on social media, remember that these devices can cause serious injury. the chamber of increased cross-section is thought to provide a discontinuity to the gas flow which leads to the creation within the chamber of a transsonic jet, which jet passes through the chamber and attaches to the walls of the nozzle bore 3 in the region of the second convergence 9 .

However, any of the heretofore described nozzle designs maybe utilized, either with or without a spacer 35 . the lift-off force of the silenced device was measured by operating it against a flat plate loaded with different masses, a displacement transducer indicating when the sealing force was insufficient to maintain contact. is a schematic cross-section along the central longitudinal axis of a needleless syringe of the first embodiment of the invention, showing a push-button gas cylinder. a gas/particle exit nozzle bounding said gas flow path for the acceleration therealong of the drawn in particles entrained in the gas. incorporated herein by reference, and have since been described in commonly owned International Publication Nos.

this pressure difference By modifying this pressure difference, the time at which the particles are drawn into the flow can be controlled.

the particle inlet passage 10 fluidly communicates with the other hole 53 of the particle cassette 50 and a more downstream part 70 of the convergence 51 . the plug 52 is aligned with filling hole 54 so that particles can be placed in the powder cavity 55 via hole 54 (see FIG.Carriers generally refer to substantially inert materials which are nontoxic and do not interact with other components of the composition in a deleterious manner. In this way, when the gas jet, with particles entrained therein, exits the nozzle's downstream exit and impacts a target area of tissue (eg.

the transsonic gas jet which issues from the constriction 5 b into the particle entrainment chamber 8 expands to create a reduced pressure region in the particle entrainment chamber 8 , in a manner similar to the venturi effect.is a magnified cross-section of a diametral slice through the agar target, showing the penetration of the individual particles.