Dose adjustment of IV for patients with acute or chronic renal impairment, based on Creatinine Clearance, Cr Cl (mL/min/1.73 m2): Advise patients to wash their hand before and after applying the cream, and to avoid unnecessary rubbing of the lesions or touching them with a towel, to avoid aggravating or transferring the infection. Side Effects Aciclovir is predominantly eliminated via the kidneys, primarily by glomerular filtration and to a lesser extent by tubular secretion.

People with particularly severe recurrent herpes labialis should be encouraged to seek medical advice. If you accidentally get cream in your eye, wash out thoroughly with warm water. Consult your doctor if you are concerned. Use the cream for up to 5 days. If the infection has not healed after this time, you can continue to use it for a further 5 days. Never apply Lipsore 5% w/w Cream to an area ofthe body called the mucous membranes, as thecream can cause irritation. These areas to avoidinclude the inside of the mouth and nose and theinside of the vagina.Continue treatment for 4 days. If your cold sores haven’t healed after this time, you can use the cream for up to 10 days in total. Use of the cream should be considered only when the potential benefit outweighs the possibility of unknown risks however the systemic exposure to aciclovir from topical application of aciclovir cream is very low. Aciclovir works by preventing the virus from multiplying and spreading so helping the immune system to fight it off. This means it will help the healing process of current sores and prevent new ones from developing. Aciclovir will not eliminate the herpes simplex virus or prevent future outbreaks of cold sores occurring. It also won’t stop you spreading the virus to others. Key features Lipsore 5% w/w Cream should not be used in the eyes. If it gets in the eyes, wash it out with plenty of water. Ifyour eye gets sore tell your doctor or pharmacist. If you forget to use Lipsore 5% w/w Cream:

In a non-standard test in rats, foetal abnormalities were observed, but only following such high subcutaneous doses that maternal toxicity was produced. The clinical relevance of these findings is uncertain. Aciclovir cream is not intended for use in your mouth or vagina, or near your eyes. This is because it may irritate these parts of your body. If you have sores in any of these areas, you should make an appointment to see your doctor, as alternative preparations can be prescribed which will be suitable for you to use. Rabbits had 1, 3 or 6% aciclovir cream in a white petrolatum vehicle introduced directly into both eyes 5 times daily at 90-minute intervals for 3 weeks. Neither autopsy nor inspection nor histological examination revealed any pathological changes in the rabbit eyes. Vial containing 250 mg Lipsore 5% will be reconstituted with 50 ml infusion solution and vial containing 500 mg Lipsore 5% will be reconstituted with 100 ml infusion solution. Besides, Vial containing 1 gm Lipsore 5% will be reconstituted with 250 ml infusion solution. 10 ml of the infusion solution will be added to the vial containing 250 mg, 500 mg and 1 gm Lipsore 5%. Shake well and transfer the required amount of solution to the infusion container. The final concentration of Lipsore 5% will be not more than 5 mg/ml. Tell your doctor or pharmacist before use ifyou are taking any regular medication on prescription or over the counter products.

Summary of Product Characteristics: Zovirax Cold Sore cream. GlaxoSmithKline Consumer Healthcare. Revised March 2014.

Do not scrub aggressively at your lips, as this can cause damage that will lead to soreness and inflammation. Cold sore sufferers should be advised to avoid transmitting the virus, particularly when active lesions are present. Apply a thin layer of the cream to the infected area and the skin immediately next to it, 5 times a day at intervals of about 4 hours. Take care not to rub the infected skin any more than you need to. 3. Wash your hands again, to avoid spreading the infection.

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It is strongly recommended that the UK National Poisons Information Service be consulted on cases of suspected or actual overdose where there is doubt over the degree of risk or about appropriate management. If you have ever had an allergic reaction to Aciclovir, valaciclovir, propylene glycol or any other ingredients of the preparation

Drugs in Pregnancy and Lactation: A Reference Guide to Fetal and Neonatal Risk, 9th edition (2011) ed. Briggs, G., Freeman, R. and Yaffe, S. Lippincott Williams & Wilkins, Philadelphia. Aciclovir does cross the placenta (Schaefer, 2007 and Briggs, 2011) however, following topical use of aciclovir there is minimal absorption through the skin (Schaefer, 2007) and systemic exposure will be low. There is also significant experience of systemic aciclovir use in pregnancy and no evidence of an increased risk of congenital defects, adverse foetal or neonatal outcomes were found during a manufacturer - CDC organised pregnancy registry between 1984 and 1999 (Briggs, 2011). Three standard animal studies revealed no teratogenic effects although abnormal thymus and immune system resulted in rats when doses causing maternal toxicity were used (Briggs, 2011). Type 1 herpes simplex virus is the usual cause of cold sores around the mouth. It also causes up to half of the cases of genital herpes. No specific studies of topical aciclovir have been carried out in pregnant women or nursing mothers.Aciclovir is an antiviral agent which is highly active in vitro against herpes simplex virus (HSV) types 1 and 2 toxicity to mammalian host cells is low. The results of a wide range of mutagenicity tests in vitro and in vivo indicate that aciclovir does not pose a genetic risk to man. In vitro and in vivo studies of aciclovir cream and aciclovir ointment versus oral aciclovir were carried out to determine the bioavailability of aciclovir in human skin. The in vitro studies used human skin biopsates, whilst the bioassays either used human skin grafts on mice or were carried out in the human eye (3 patients). Paediatric Formulary Committee. BNF for Children 2015-2016. London: BMJ Group, Pharmaceutical Press, and RCPCH Publications; 2015. inside your mouth, to treat mouth ulcers and in theeyes or genital areas. Take special care with Lipsore 5% w/wCream: