The "Essential Amphetamines" are what Shulgin describes as ten amphetamines that differ from natural products such as safrole or myristicin by an amine group ( PIHKAL Entry #157 TMA). The list consists of: Like LSD, while 2C-B is capable of producing a full range of low and high-level hallucinatory states, they are comparatively rare and inconsistent at higher levels while common at lower levels. They generally include the following effects: Users have reported experiencing hypertension, hyperthermia and tachycardia at higher doses. [19] As such, those with pre-existing heart conditions should avoid using 2C-B, and users monitor their temperature and heart-rate and respond accordingly. Heavy physical exertion while on 2C-B is discouraged.

Papaseit, E., Farré, M., Pérez-Mañá, C., Torrens, M., Ventura, M., Pujadas, M., ... & González, D. (2018). Acute Pharmacological Effects of 2C-B in Humans: An Observational Study. Frontiers in Pharmacology, 9, 206. https://doi.org/10.3389/fphar.2018.00206 PLUS FOUR (++++) A rare and precious transcendental state, which has been called a ‘peak experience’, a ‘religious experience,’‘divine transformation,’ a ‘state of Samadhi’ and many other names in other cultures. It is not connected to the +1, +2, and +3 of the measuring of a drug’s intensity. It is a state of bliss, a participation mystique, a connectedness with both the interior and exterior universes, which has come about after the ingestion of a psychedelic drug, but which is not necessarily repeatable with a subsequent ingestion of that same drug. If a drug (or technique or process) were ever to be discovered which would consistently produce a plus four experience in all human beings, it is conceivable that it would signal the ultimate evolution, and perhaps the end of, the human experiment.

#96 M

This is the online version of the second half of the book “PiHKAL: A Chemical Love Story” by Alexander and Ann Shulgin. While reading this book I attended a lecture given by Nobel laureate Kary Mullis. Kary Mullis received the Nobel Prize for Chemistry in 1993 for the development of PCR. During his lecture he commented on the first scientific paper he published in Nature, in 1968. He described it as a sophomoric astrophysical hypothesis called "The Cosmological Significance of Time Reversal." He told the audience he ate LSD while writing it. Needless to say Nature is still probably a little embarrassed about publishing it.

Dissociatives - When combined with dissociatives, the geometry, euphoria, dissociation, and hallucinatory effects are often greatly enhanced. Dissociative-induced holes, spaces, and voids while under the influence of 2C-B have significantly more vivid visuals than dissociatives alone. It also results in more intense internal hallucinations and corresponding confusion which can develop into delusions and psychosis. Alexander Shulgin lived his life in a unique position where his expertise in the field of mind altering drugs gave him the freedom to dance the lines of legality in the design, synthesis, and consumption of new substances. PiHKAL: A Chemical Love Story is a book by Dr. Alexander Shulgin and Ann Shulgin, published in 1991. The subject of the work is psychoactive phenethylamine chemical derivatives, notably those that act as psychedelics and/or empathogen-entactogens. The main title, PiHKAL, is an acronym that stands for "Phenethylamines I Have Known and Loved." Smaller doses (under 15 mg) are reported to be useful as a sensory and aesthetic enhancer (in a manner somewhat similar to MDMA) while larger doses are reported to produce a distinct mind-manifesting psychedelic effect.

The Chemistry Continues

How long will this last, this delicious feeling of being alive, of having penetrated the veil which hides beauty and the wonders of celestial vistas? It doesn't matter, as there can be nothing but gratitude for even a glimpse of what exists for those who can become open to it.” At the present time, restrictive laws are in force in the United States and it is very difficult for researchers to abide by the regulations which govern efforts to obtain legal approval to do work with these compounds in human beings…. Anxiety& Paranoia - while possible at most doses, this effect generally occurs at a considerably lower intensity compared to classical psychedelics such as LSD and psilocybin mushrooms.

Of course, there are many ways to alter your consciousness and your perceptions; there always have been, and new ways will keep being developed. Drugs are only one way, but I feel they're the way that brings about the changes most rapidly, and - in some ways - most dependably. Which makes them very valuable when the person using them knows what he's doing." In the 1970s, it first saw use as a therapeutic aid by a small circle of American psychotherapists and was considered one of the best substances for this purpose due to its short duration, relative absence of side effects, and comparably mild nature. [4] TiHKAL: The Continuation is a 1997 book written by Alexander Shulgin and Ann Shulgin about a family of psychoactive drugs known as tryptamines. TiHKAL is an acronym that stands for "Tryptamines I Have Known and Loved." The book is a sequel to PiHKAL: A Chemical Love Story.

I went into the book desiring mostly the second half, but fell in love with the first half as well. Shulgin is truly a genius and his way of viewing the world is touching and very powerful. The same goes for Ann. Many times while reading their story I found myself completely enraptured and falling in love with the both of them. One quote from Ann is one I intend to live my life by. Analysis enhancement - This introspection dominant effect is only manifested consistently in the context of a non-social setting in which the user is alone.

trypt-amine \ 'trip-ta-,men \ n. [tryptophan fr. tryptic, fr. trypsin, fr. Gk. tryein, to wear down (from its occurence in pancreatic juice as a proteolytic enzyme) + amine fr. NL ammonia] 1: A naturally occurring compound found in both the animal and plant kingdoms. It is an endogenous component of the human brain. 2: Any of a series of compounds containing the tryptamine skeleton, and modified by chemical constituents at appropriate positions in the molecule. Psychedelics - When used in combination with other psychedelics, each substance's physical, cognitive and visual effects intensify and synergize strongly. The synergy between those substances is unpredictable, and for this reason generally not advised. If choosing to combine psychedelics, it is recommended to start with significantly lower dosages than one would take for either substance individually.Found in the Sweet Flag ( Acorus calamus ) and plants of the genus Asarum (from which it gets its name). Precursor to TMA-2. Shulgin's life is remarkable, simply because he gets away with so much. Most chemists of international accalim don't typically advocate illegal drugs for example. Every weekend Shulgin and a close group of friends take differing doses of newly-devised psychoactive drugs. It seems Shulgin himself has probably been ingesting psychedelic substances every second day for his entire adult life, perhaps inadvertently proving that responsible drug use is no detriment to scientific genius. I'll sign off this review with a transcript of the picture above, because I know that sometimes food is best eaten pure.