Atkin et al, (2020) Wound bed preparation: a case series using polyhexanide and betaine solution and gel—a UK perspective

Murphy C, Atkin L, Swanson T, et al. Defying hard-to-heal wounds with an early antibiofilm intervention strategy: wound hygiene. Journal of Wound Care 2020; 29(Sup3b): S1-S26.

Formulary

In Vitro Evaluation of Polihexanide, Octenidine and NaClO/HClO-BasedAntiseptics against Biofilm Formed by Wound Pathogens Halim AS, Khoo TL, Mat Saad AZ. Wound bed preparation from a clinical perspective. Indian Journal of Plastic Surgery 2012; 45(2): 193-202

Atkin L, Bućko Z, Montero EC, et al. Implementing TIMERS: the race against hard-to-heal wounds. Journal of Wound Care 2019; 28: S1-S50. Durante et al. Evaluation of the effectiveness of a polyhexanide and propyl-betaine based gel in the treatment of chronic wounds. Minerva Chir 2014;69:283-92 Bellingeri A, Falciani F, Traspedini P, et al. Effect of a wound cleansing solution on wound bed preparation and inflammation in chronic wounds: a single-blind RCT. J Wound Care 2016; 25(3): 160, 2-6, 8. Guest JF, Fuller GW, Vowden P. Cohort study evaluating the burden of wounds to the UK’s National Health Service in 2017/2018: update from 2012/2013. BMJ Open 2020;10:e045253. doi:10.1136/bmjopen-2020-045253 Most of the evidence about Prontosan's effectiveness is not of good quality. It may speed up wound healing and reduce infections compared with saline in chronic wounds, but more evidence is needed to confirm this. There is very little evidence about using Prontosan for treating acute wounds.Valenzuela AR, Perucho NS. The effectiveness of a 0.1% polyhexanide gel. Revista de enfermeria (Barcelona, Spain) 2008; 31(4): 7‐12. Parnham A, Bousfield C. The influence of matrix metalloproteases and biofilm on chronic wound healing: a discussion. British journal of community nursing 2018; 23: S22-S9. Andriessen AE, Eberlein T. Assessment of a wound cleansing solution in the treatment of problem wounds. Wounds: A Compendium of Clinical Research & Practice 2008; 20(6): 171-5. Andriessen (2008) is a retrospective comparative case series of 112 patients with venous leg ulcers with a follow-up time of 6 months. The EAC considered that Andriessen 2008 was a suitable data source because of the larger number of patients and longer follow up. However, the study was at high risk of bias because of potential selection and reporting bias.