The Persian physician Abū ‘Alī al-Husayn ibn Sina ("Avicenna") described opium as the most powerful of the stupefacients, in comparison to mandrake and other highly effective herbs, in The Canon of Medicine. The text lists medicinal effects of opium, such as analgesia, hypnosis, antitussive effects, gastrointestinal effects, cognitive effects, respiratory depression, neuromuscular disturbances, and sexual dysfunction. It also refers to opium's potential as a poison. Avicenna describes several methods of delivery and recommendations for doses of the drug. [24] This classic text was translated into Latin in 1175 and later into many other languages and remained authoritative until the 19th century. [25] Şerafeddin Sabuncuoğlu used opium in the 14th-century Ottoman Empire to treat migraine headaches, sciatica, and other painful ailments. [26] Reintroduction to Western medicine [ edit ] Latin translation of Avicenna's Canon of Medicine, 1483

a b c d e f g Dikotter, Frank (2004). Narcotic Culture: A History of Drugs in China. Hurst. p.3. ISBN 978-0226149059.Anderson, Stuart; Berridge, Virginia (2000). "Opium In 20th-Century Britain: Pharmacists, Regulation And The People". Addiction. 95 (1): 23–36. doi: 10.1046/j.1360-0443.2000.951234.x. PMID 10723823. Anil Aggrawal (1995). "CHAPTER 2: THE STORY OF OPIUM". Narcotic Drugs. New Delhi: National Book Trust. ISBN 978-81-237-1383-0. Simon O'Dochartaigh. "HON Mother & Child Glossary, Meconium". hon.ch. Archived from the original on May 1, 2021 . Retrieved April 4, 2016. William Travis Hanes; Frank Sanello (2004). Opium Wars: The Addiction of One Empire and the Corruption of Another. Sourcebooks, Inc. pp.78–. ISBN 978-1-4022-0149-3. Heydari, M; Hashempur, M. H.; Zargaran, A (2013). "Medicinal aspects of opium as described in Avicenna's Canon of Medicine". Acta medico-historica Adriatica. 11 (1): 101–12. PMID 23883087.

Description of the Culture of the White Poppy and Preparation of Opium, as Practised in the Province of Bahar". The Asiatic Journal and Monthly Miscellany. Vol.3. Wm. H. Allen & Company. 1817 . Retrieved May 31, 2022. Richard Askwith; The Sunday Times (September 13, 1998). "How aspirin turned hero" . Retrieved May 2, 2007. It carries a luminous and sensual essence. It is refreshing to apply to. The main accords felt are coffee, white flower, and citrus. Opiates (e.g., morphine, codeine, and thebaine) exert their main effects on the brain and spinal cord. Their principal action is to relieve or suppress pain. The drugs also alleviate anxiety; induce relaxation, drowsiness, and sedation; and may impart a state of euphoria or other enhanced mood. Opiates also have important physiological effects: they slow respiration and heartbeat, suppress the cough reflex, and relax the smooth muscles of the gastrointestinal tract. Opiates are addictive drugs; they produce a physical dependence and withdrawal symptoms that can only be assuaged by continued use of the drug. With chronic use, the body develops a tolerance to opiates, so that progressively larger doses are needed to achieve the same effect. The higher opiates—heroin and morphine—are more addictive than opium or codeine. Opiates are classified as narcotics because they relieve pain, induce stupor and sleep, and produce addiction. The habitual use of opium produces physical and mental deterioration and shortens life. An acute overdose of opium causes respiratory depression which can be fatal. Forbes, Andrew; Henley, David (2011). Traders of the Golden Triangle. Chiang Mai: Cognoscenti Books. ASIN B006GMID5KMartin, Steven. The Art of Opium Antiques. Chiang Mai: Silkworm Books, 2007. Photographs and history of Chinese and Vietnamese opium-smoking paraphernalia. Michot, Yahya. L’opium et le café. Traduction d’un texte arabe anonyme et exploration de l'opiophagie ottomane (Beirut: Albouraq, 2008) ISBN 978-2-84161-397-7 Carstairs C. (2006). "Jailed for Possession: Illegal Drug Use, Regulation, and Power in Canada, 1920–61". Archived from the original on January 25, 2003. Opium contains two main groups of alkaloids. Phenanthrenes such as morphine, codeine, and thebaine are the main psychoactive constituents. [153] Isoquinolines such as papaverine and noscapine have no significant central nervous system effects. Morphine is the most prevalent and important alkaloid in opium, consisting of 10–16 percent of the total, and is responsible for most of its harmful effects such as lung edema, respiratory difficulties, coma, or cardiac or respiratory collapse. Morphine binds to and activates mu opioid receptors in the brain, spinal cord, stomach and intestine. Regular use can lead to drug tolerance or physical dependence. Chronic opium addicts in 1906 China [48] consumed an average of eight grams of opium daily; opium addicts in modern Iran [154] are thought to consume about the same.