American Gastroenterological Association. Consideration for use of probiotics in gastrointestinal diseases: clinical decision support tool. Gastroenterology 2020; 159: 706. [ PubMed abstract] Hill C, Guarner F, Reid G, Gibson GR, Merenstein DJ, Pot B, et al. The International Scientific Association for Probiotics and Prebiotics consensus statement on the scope and appropriate use of the term probiotic. Nat Rev Gastroenterol Hepatol 2014;11:506-14. [ PubMed abstract] Results of clinical trials that assessed the impact of probiotics on obesity-related endpoints have been inconsistent. One 12-week clinical trial, for example, randomized 210 healthy adults age 35 to 60 years who had large amounts of visceral fat to consume 200 g/day fermented milk containing 10 7, 10 6, or 0 (control) CFU of Lactobacillus gasseri SBT2055 (LG2055) per gram of milk [ 59]. Participants who received 10 7 or 10 6 CFU/g milk of Lactobacillus gasseri experienced significant reductions in visceral fat area (mean reductions of 8.5% and 8.2%, respectively), body mass index, waist and hip circumference, and body fat mass compared with the control group. In another randomized clinical trial, daily supplementation with 3.24 x 10 8 CFU Lactobacillus rhamnosus CGMCC1.3724 for 24 weeks combined with an energy-restricted diet for the first 12 weeks (500 kcal/day less than estimated calorie needs) did not significantly affect weight loss compared with placebo in 125 adults age 18 to 55 years with obesity [ 60]. However, the Lactobacillus supplementation did significantly reduce body weight after 12 weeks (loss of 1.8 kg) and 24 weeks (loss of 2.6 kg) compared with placebo in the 77 female participants.

A Healthy Gut for a Healthy Life Concentrated - Probiotics

High levels of cholesterol in the blood or cholesterol trapped in arterial walls are risk factors for cardiovascular disease (CVD). Low-density lipoprotein (LDL) carries cholesterol to tissues and arteries. The higher the LDL level, the greater the risk is for CVD. High-density lipoprotein (HDL) carries cholesterol from the tissues to the liver and leads to its excretion. A low level of HDL increases a person’s risk of CVD. Both LGG and Saccharomyces boulardii have been shown to reduce the risk of AAD. In a systematic review and meta-analysis of 12 RCTs with a total of 1,499 children and adults, treatment with LGG (4 x 10 8 to 12 x 10 10 CFU) compared with placebo or no additional treatment for 10 days to 3 months reduced the risk of AAD in patients treated with antibiotics from 22.4% to 12.3% [ 29]. However, when the 445 children and 1,052 adults were evaluated separately, the difference was statistically significant in children only. Although the optimal dose of LGG is unclear, 1 to 2 x 10 10 CFU/day reduced AAD risk in children by 71% [ 29]. Taking probiotics within 2 days of the first antibiotic dose is more effective than starting to take them later. This gives the bad bacteria an opportunity to multiply and grow and may cause side effects such as antibiotic-associated diarrhoea and subsequently lead to permanent changes in the structure and composition of our microbiota.Each one-a-day capsule contains 17.5 billion live bacteria, combining the Lab4 consortium of bacteria with Lactobacillus gasseri. Each capsule also contains cranberry extract and vitamin B6, which contributes to the regulation of hormonal activity. Key features

Probiotic Products deliver a Healthy Gut for a Healthy Life

Each capsule contains 12.5 billion friendly bacteria along with key nutrients to provide additional support for digestion (calcium) and immunity (vitamins C and D, zinc and selenium). Key features In contrast, another meta-analysis of five randomized clinical trials with a total of 889 participants found that Lactobacillus rhamnosus GG (LGG) supplementation did not reduce the risk of eczema in children up to age 4 years, regardless of the timing of administration (to the mothers during pregnancy and/or during breastfeeding or to the infants directly) [ 14]. Probiotics usually exert their effects in the gastrointestinal tract, where they may influence the intestinal microbiota. Probiotics can transiently colonize the human gut mucosa in highly individualized patterns, depending on the baseline microbiota, probiotic strain, and gastrointestinal tract region [ 4]. Numerous probiotic studies have evaluated the effects of various species and strains of bacteria on the prevention of atopic dermatitis, and several meta-analyses have synthesized the findings of these studies. These studies and meta-analyses show that exposure to probiotics during pregnancy and in early infancy might reduce the risk of developing atopic dermatitis in children. For example, a 2018 meta-analysis included 27 randomized controlled trials (RCTs) and one controlled cohort study in a total of 6,907 infants and children exposed to probiotics in utero for 2 weeks to 7 months (via maternal oral supplementation) and/or by oral administration to the infants after birth for 2 to 13 months [ 13]. Between age 6 months and 9 years, probiotic treatment with single strains or mixtures that included Lactobacillus, Bifidobacterium, and Propionibacterium strains significantly reduced the risk of atopic dermatitis from 34.7% in the control group to 28.5% in the probiotic group.Bosch M, Fuentes MC, Audivert S, Bonachera MA, Peiro S, Cune J. Lactobacillus plantarum CECT 7527, 7528 and 7529: probiotic candidates to reduce cholesterol levels. J Sci Food Agric 2014;94:803-9. [ PubMed abstract] A balanced microbiome helps to support a healthy digestive system, which is central to supporting our health generally. Inflammatory bowel disease (IBD) is a chronic inflammatory disease that includes ulcerative colitis and Crohn’s disease [ 30]. The exact cause of IBD is unknown but is probably a combination of inherited and environmental factors, including genetic alterations and immune system dysfunction [ 31]. Various treatments for IBD, including oral steroids and other medications, are available, but no cure exists. The most complete combination of friendly bacteria ProVen Probiotics 50 Billion-ShapeLine has now been shown to support a ‘shapelier you’ when taken regularly over a six-month period – at one capsule a day. Gastroenterology consensus guidelines on the management of inflammatory bowel disease in adults. Gut 2019; 68(Suppl 3): s1-s106.

50 Billion - ShapeLine - ProVen Probiotics

Guarino A, Ashkenazi S, Gendrel D, Lo Vecchio A, Shamir R, Szajewska H, et al. European Society for Pediatric Gastroenterology, Hepatology, and Nutrition/European Society for Pediatric Infectious Diseases evidence-based guidelines for the management of acute gastroenteritis in children in Europe: update 2014. J Pediatr Gastroenterol Nutr 2014;59:132-52. [ PubMed abstract] Principi N, Cozzali R, Farinelli E, Brusaferro A, Esposito S. Gut dysbiosis and irritable bowel syndrome: The potential role of probiotics. J Infect 2018;76:111-20. [ PubMed abstract] Didari T, Solki S, Mozaffari S, Nikfar S, Abdollahi M. A systematic review of the safety of probiotics. Expert Opin Drug Saf 2014;13:227-39. [ PubMed abstract] Suzumura EA, Bersch-Ferreira AC, Torreglosa CR, da Silva JT, Coqueiro AY, Kuntz MGF, et al. Effects of oral supplementation with probiotics or synbiotics in overweight and obese adults: a systematic review and meta-analyses of randomized trials. Nutr Rev 2019. [ PubMed abstract] Bile salt hydrolase activity, which increases the need for new bile acids and thus reduces serum cholesterol levels [ 50-52]

Overall, the available evidence indicates that probiotics might reduce some symptoms of IBS. However additional high-quality clinical trials are needed to confirm the specific strain, dose, and duration of treatment required as well as the type of IBS (such as with predominant diarrhea or constipation) that can be treated effectively with probiotics. Hypercholesterolemia

ProVen Probiotics ProVen Probiotics

Ishimwe N, Daliri EB, Lee BH, Fang F, Du G. The perspective on cholesterol-lowering mechanisms of probiotics. Mol Nutr Food Res 2015;59:94-105. [ PubMed abstract] Munoz P, Bouza E, Cuenca-Estrella M, Eiros JM, Perez MJ, Sanchez-Somolinos M, et al. Saccharomyces cerevisiae fungemia: an emerging infectious disease. Clin Infect Dis 2005;40:1625-34. [ PubMed abstract]Tsai CC, Lin PP, Hsieh YM, Zhang ZY, Wu HC, Huang CC. Cholesterol-lowering potentials of lactic acid bacteria based on bile-salt hydrolase activity and effect of potent strains on cholesterol metabolism in vitro and in vivo. ScientificWorldJournal 2014;2014:690752. [ PubMed abstract] Overall, the available evidence suggests that starting probiotic treatment with LGG or Saccharomyces boulardii within 2 days of the first antibiotic dose helps reduce the risk of AAD in children and adults age 18 to 64, but not in elderly adults. There is no evidence to suggest that the benefits are greater when more than one probiotic strain is used. Inflammatory bowel disease Salminen MK, Tynkkynen S, Rautelin H, Saxelin M, Vaara M, Ruutu P, et al. Lactobacillus bacteremia during a rapid increase in probiotic use of Lactobacillus rhamnosus GG in Finland. Clin Infect Dis 2002;35:1155-60. [ PubMed abstract] The product contains Lab4, the most researched group of friendly bacteria in the UK, along with Lactobacillus plantarum, an additional strain of live bacteria to provide a high-strength multi-strain product – with a total of 50 billion live bacteria per capsule.