If one is in the path of the Figure and they cannot escape it or outrun it, they can use the crucifix to buy them time to escape before the Figure breaks free. Dupe and Void are currently the only entities that cannot be seen being banished directly. Dupe is only implied that to be banished.

There is reason to suspect that the crucifix's design is inspired by Phasmophobia's crucifix due to the similarity in their designs. Both have a similar use animation, with the crucifix burning/lighting up and then breaking. [ citation needed] If a player attempts to use the crucifix in The Rooms, there will be a message saying "Your crucifix feels lighter than normal..." When the crucifix is used on an entity, Rush's far ambience can be heard faintly. [ citation needed] There was a problem when using the crucifix on Rush or Ambush when in multiplayer, as the ray-casting of said entities would still kill other players while the entities were getting banished by the crucifix. This has since been fixed. Attempting to use the crucifix on El Goblino will result in him saying "¡Oye! Watch where you swing that thing, hombre! Uff!"In the sigil's inner circle is a message in the font "WingDings", a font that displays letters as symbols. While the Figure and Seek are also hostile entities, the crucifix cannot banish them. It will only stun them for a period of time. Using a crucifix on Rush is only useful if all closets are taken or a double-rush occurs in the Greenhouse. If the player is using safespots to hide from either Rush or Ambush, holding the crucifix out while being at the safespot can be a great way to ensure survival, as if in case either Rush or Ambush catches the player at the safespot, the crucifix will be used, saving any and all players hiding at that spot, and if the safespot worked, the crucifix will not activate, which can be saved for later. Since the crucifix will not affect any entities inside The Rooms, it's recommended to use it before then. However, if the player is aiming to preserve the Shakelight or NVCS-3000, it's still a good idea to keep it, to reduce the risk of dying before reaching the rift.

Using the crucifix against either Seek or the Figure will appear to work at first, though the sigil on the floor will suddenly turn red and the trapped entity will be released as a shattering sound is heard. Using crucifix on Ambush is effective if there are not enough closets or if a player is unexperienced. The crucifix does not work on A-60, A-90, or A-120. This is likely due to Guiding Light not being present in The Rooms.

There is a glitch where three players, each holding a crucifix and using it on Seek at the same time, will glitch Seek out of the Hotel, and it will be "banished". Using crucifix on Seek can be useful in 2023 April Fools Event or if the player runs in the wrong direction. However, using the crucifix on Void will restrict it from dealing significant damage to the player. It also contains a crescent in the middle of the hexagram, which is depicted as the Islamic crescent. Though to actually depict it, it has to be paired with a five-pointed star.

This also supports that the Guiding Light is not present in The Rooms, as wielding the crucifix will give the player a message saying "Your crucifix feels lighter than normal..." and will not work against the entities that inhabit The Rooms. This adds that Guiding Light powers the item.

This message, when translated and ran through the Caesar cipher, reads "OneOfTheThreeArchitectsMarkedByCelestialsAssistsYou." This is likely due to the strength of the entities; lore-wise, they are important and powerful antagonists, while game-wise they serve as the most extreme tests of the player's skills, and shouldn't be skipped. These are based on gameplay experiences and how the crucifix might be useful or not during some situations. Crucifixes in biblical stories are known for banishing demons or exorcising them, concluding that the entities are demons of some sort. The crucifix does not work on April Fools Exclusive Entities (Jeff The Killer, Banana Peel, Greed, Evil Key, Subspace Tripmine).