High-dose corticosteroids, such as prednisolone (this vaccine should not be given until at least three months after stopping treatment with high doses of corticosteroids taken by mouth or injection) • Immunosuppressants The indazole analogue benzydamine has physicochemical properties and pharmacological activities which differ from those of the aspirin-like NSAIDs. Unlike aspirin-like NSAIDs which are acids or metabolised to acids, benzydamine is a weak base. In further contrast, benzydamine is a weak inhibitor of the prostaglandin synthesis. Only at concentration of 1mM and above benzydamine effectively inhibits cyclooxygenase and lipooxygenase enzyme activity. It mostly exerts its effects through inhibition of the synthesis of proinflammatory cytokines including tumour necrosis factor-alpha (TNF-α) and Interleukin-1β (IL-1β) without significantly affecting other pro-inflammatory (IL-6 and 8) or anti-inflammatory cytokines (IL-10, IL-1 receptor antagonist). Further mechanisms of action are hypothesised including the inhibition of the oxidative burst of neutrophils as well as membrane stabilisation as demonstrated by the inhibition of granule release from neutrophils and the stabilization of lysosomes. The local anaesthetic activity of the compound has been related to an interaction with cationic channels Fortunately, the flu vaccination is available every year on the NHS, in the form of a nasal spray flu vaccine, to help protect children who are at risk of flu. For more advice on what to expect after vaccinations and how to treat common side effects, read vaccination tips for parents. What's in the nasal spray flu vaccine?

The nasal flu vaccine can’t cause flu in children with a healthy immune system. Very common side-effects The nasal spray vaccine contains small traces of gelatine derived from pigs (porcine gelatine). If you do not accept the use of porcine gelatine in medical products, the injected vaccine is available as an alternative.

The vaccine should be repeated each year before the start of the flu season. The best time to have it is from October to late November.

Have a condition that increases the risk of severe varicella - eg, immunosuppressed patients, neonates and pregnant women. Please consult your pharmacist or doctor if you are currently taking any other medicines as this may cause an interaction. severe skin rash (ulcers and blistering that may involve the eyes, mouth, and/or genitals; red, often itchy spots which start on the limbs and sometimes on the face and the rest of the body) (Stevens-Johnson syndrome; erythema multiforme) Inflammation of the brain (encephalitis) and ataxia (problems co-ordinating movements) are very rare complications. The nasal spray flu vaccine gives children the best protection against flu. The injected flu vaccine is a good alternative if the nasal spray vaccine cannot be used.

This medicine contains 14 mg of alcohol (ethanol) in each puff. The amount in 1 puff of this medicine is equivalent to less than 1 ml beer or 1 ml wine.The small amount of alcohol in this medicine will not have any noticeable effects. If you have a child with a certain long-term health condition, you can ask the GP surgery to give them the vaccine instead of them having it at school if you prefer.