Beebe-Dimmer, J. L., Pfeifer, J. R., Engle, J. S., & Schottenfeld, D. (2005). The epidemiology of chronic venous insufficiency and varicose veins. Annals of Epidemiology, 15(3), 175-184. One of the first studies to assess the effectiveness of red vine leaf extracts (Antistax) asked 71 people with leg swelling (due to chronic venous insufficiency) to take 360mg red vine leaf extracts, or placebo during two separate periods of 6 weeks. This meant that each person tried both treatments and acted as their own controls. Symptoms of chronic venous insufficiency include feelings of heaviness, aching legs, swelling of the ankles or calves, sensations of tension in the legs and pain. The overlying skin may become dry and discoloured and acquires a characteristic mottled pigmentation. Patients were randomly assigned to a double-blind treatment with placebo, 360 mg AS 195 or 720 mg AS 195 once daily for 12 weeks, preceded and followed by a single-blind 2-week placebo treatment for baseline run-in and end-of-trial washout, respectively. Study criteria were evaluated at baseline, after 6 and 12 weeks of treatment and 2 weeks after discontinuation of treatment.

Of the 260 patients enrolled and randomized, 219 completed the study in accordance with the protocol. In the intention-to-treat analysis (N = 257), the mean (+/- SD) lower leg volume (measured by water displacement plethysmography) of the patients treated with placebo (N = 87) increased by 15.2 +/- 90.1 g (displaced water mass) and by 33.7 +/- 96.1 g after 6 and 12 weeks compared to baseline. In contrast, for patients treated with AS 195, lower leg volume decreased, and after 12 weeks of treatment, the difference in mean lower leg volume between the active treatment groups and the placebo group was -75.9 g (95% CI: -106.1 to -45.8 g) and -99.9 g (95% CI: -130.3 to -69.6 g) for the group treated with 360-mg AS 195 (N = 86) and 720-mg AS 195 (N = 84), respectively. The changes in calf circumference showed a similar pattern: in patients treated with AS 195, both the higher dose (720 mg) and, albeit to a lesser extent, the lower dose (360 mg) resulted in a clear reduction in circumference over time, whereas, circumference remained largely unchanged in patients treated with the placebo (95% CI of the estimated treatment effects vs. placebo after 12 weeks: -1.40 to -0.56 cm and -1.73 to -0.88 cm for 360 and 720 mg AS 195, respectively). These differences were statistically significant (p < 0.001). The reductions in ankle circumference were qualitatively similar but quantitatively less marked. Subjectively, there was an improvement in key CVI symptoms (VAS) at 6 weeks with all treatments, but a further improvement at week 12 was seen only in the active treatment groups; at 12 weeks, the changes compared to baseline were significantly greater (p < 0.001) in both active treatment groups than in the placebo group. The treatments were well tolerated; Adverse events were rare and usually mild. Two adverse events (AEs) during treatment with the placebo led to hospitalization and were hence labeled as 'serious'. Three further patients were withdrawn because of AEs which occurred during treatment with the placebo. Red grapes are well-known for their beneficial antioxidants, and red vine leaf extracts are derived from the leaves of the same grapevine, Vitis vinifera. Red vine leaves are harvested when they achieve a rich red colour and have the highest content of antioxidant polyphenols. Their extracts are used medicinally for their circulatory effects, especially within leg veins. They reduce inflammation, stabilise the endothelial lining of capillaries and veins, and promote their repair to reduce swelling of the ankles. Red vine leaf benefits This product has been improved. At Healthspan we are constantly striving to provide products of the highest quality and sometimes that means we need to make changes to your supplements. Our new and improved Vein-Vine formulation now contains vitamins B1 and C, to support your heart health and blood vessels, while remaining at the same price as before. What is Vein−Vine? In Germany, as many as 7 % of the general population take red vine leaf extracts (Antistax), usually on the advice of their doctor, to reduce swelling and other leg symptoms associated with chronic venous insufficiency. This was followed by another study, involving 248 patients with more severe chronic venous insufficiency, classed as moderate-to-severe. Half took 720 mg red vine leaf extract per day for 12 weeks, while half took inactive placebo. The red vine leaf extract significantly reduced lower limb volume by 20 ml more than placebo (27ml versus 7ml) with an associated decrease in leg pain.Coleridge Smith, P. D. (2001). Update on chronic-venous-insufficiency-induced inflammatory processes. Angiology, 52(1_suppl), S35-S42. Other studies found similar reductions in calf swelling, sensations of heaviness and pain from taking red vine leaf extracts. Red vine leaf and venous thrombosis

If the leg vein valves collapse, then swollen veins become distended and tortuous and may bulge beneath the skin to form varicose veins. Holland & Barrett Leg Vein Formula is carefully developed to help maintain healthy circulation in the legs. The capsules contain Red Vine leaf extract which contributes to good blood flow in the legs, along with grapeseed extract and Vitamin C. Researchers next assessed the best dose in a 12-week study involving 257 men and women with mild to moderate chronic venous insufficiency. One group took 360mg red vine leaf extracts per day, one took 720mg daily, while another took placebo. Red vine leaf extract (RVLE) is a herbal medicine containing several flavonoids, with quercetin-3-O-beta-glucuronide and isoquercitrin (quercetin-3-O-beta-glycoside) as the main components.

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A systematic literature search was performed to identify trials that reported the impact of red vine leaf extract on CVI. The primary outcomes investigated were Leg (limb) volume, calf circumference, ankle circumference, tired and heavy legs, a sensation of tension, tingling sensation, and pain.

When taking the red vine leaf extract, blood flow through their skin capillaries (measured using a laser Doppler device) significantly increased (by +241.8 units compared with a reduction of -41.0 units with placebo). When taking red vine leaf extracts, oxygen levels in their micro circulation also improved, while swelling and leg circumference decreased. A cooling leg gel containing red vine leaf extracts that is designed to soothe and refresh tired, heavy legs, is also available.Red Vine Leaf Extract, Vitamin C (as Ascorbic Acid), Capsule Shell (Hydroxypropyl Cellulose), Grapeseed Extract, Bulking Agent (Microcrystalline Cellulose), Anti-Caking Agents (Magnesium Stearate, Silicon Dioxide). Holland & Barrett Leg Vein Formula contains ingredients that help to maintain a healthy circulation and blood flow in the legs. The researchers concluded that adding angioprotectors ( red vine leaf extract) to standard medical treatment helps to correct endothelial dysfunction (the ability of veins to recover and dilate) and may improve the immediate results for patients with acute venous thrombosis. Red vine leaf dose