The first thing that should be done is to remove the cause of the inflammation, which is to kill the infecting bacteria and remove any pus or dead tissue, that provide a medium for their growth. How does honey heal? For each honey type there was > 90% decrease in the MIC when 3% (v/v) royal jelly was added; a 66.6% decrease when 2% (v/v) royal jelly was added and a 50% decrease in MIC when 1% (v/v) royal jelly was added. Kwakman et al (2011) 52 investigated the antimicrobial effects of supplementing Revamil honey with the antimicrobial peptides LL-37 and the synthetic peptide bacterial peptide 2 (BP2). They reported that the antimicrobial activity of LL-37 was inhibited in the presence of honey, but this was not the case for BP2. Using a liquid bactericidal assay, it was shown that Revamil honey supplemented with 75µM BP2 had more rapid antibacterial activity against MRSA and extended spectrum β lactamase (ESBL) E. coli and had a broader spectrum of antibacterial activity than Revamil alone. The authors considered supplementing the honey with hydrogen peroxide or MGO but were concerned that high levels of these components may not be biocompatible. From this point of view it is safer to use it on any kind of wound, no matter how deep it is. What is Activon? Although the honey is not absorbed into the blood stream, we advise monitoring the levels of patients with diabetes.

Synergistic antimicrobial activity of Medihoney and rifampicin combination against MRSA and clinical isolates of S. aureus. Simple manuka and kanuka are also very good on any type of skin infection, in Australia being widely use in treating infected wounds in animals. When first applied, you may feel a discomfort and may need to take an analgesic. The initial discomfort usually subsides, however if it does continue, discontinue use and irrigate the wound with saline solution. Are these products complying with the regulations? Twist off the tube cap and apply directly to the wound. If the wound starts to ooze, dress it with an absorbent bandage or dressing after applying Activon Manuka Honey.Low pH. Usually between 3.3 and 4.6, with some exception: chestnut honey (pH, between 5 and 6) and honeydew honey (pH between 4.5 and 6.5). Hydrogel is commonly used as a wound dressing. It is composed of polymers suspended in water and is thought to provide hydration to a wound and promote healing. El-Kased et al (2017) 53 reported that an Egyptian honey (75%) chitosan hydrogel formula had superior antimicrobial activity against P. aeruginosa, S. aureus, K. pneumonia and Streptococcus pyogenes in a disc diffusion assay in comparison to pure honey. For example, the mean zone of inhibition for the honey 75% chitosan hydrogel formula against S. aureus was 20.2 ± 0.4 vs 15.1 ± 0.9 for honey. This formula was also superior to pure honey in the healing of 10 mm burn wounds induced in mice using a heated metallic rod. The wounds were treated with either the honey 75% chitosan hydrogel formula or honey for 9 days. By day 9, the honey chitosan treated wounds had a mean diameter of 3.8 ± 0.2 mm versus 5.3 ± 0.8 mm in the honey only treated group. Furthermore, an alginate-based honey hydrogel containing thymol-based honey from Damavand, Iran was reported to have superior wound healing ability in rats with infected burn wounds than honey alone. 54 Wound healing was faster in the alginate-based honey hydrogel treated group in comparison to the honey only group. In another study, a paste composed of carboxymethyl cellulose hydrogel (50%), water (30%) and chestnut honey (20%) had superior antimicrobial activity against S. aureus and E.coli in a disc diffusion assay than a paste composed of carboxymethyl cellulose hydrogel (50%) and water only. 55 Furthermore, the paste containing 20% chestnut honey had superior wound healing ability in comparison to the paste without honey in the treatment of wounds inflicted in the dorsal skin of mice. Tavaloki and Tang (2017) 56 designed a wound dressing consisting of a high concentration of honey, polyvinyl alcohol hybrid hydrogel and borax as a crosslinking agent. High concentrations of honey are important for wound healing but can negatively affect the physicochemical properties of hybrid hydrogels. The use of borax apparently overcomes this problem and permits the incorporation of high concentrations of honey without negative effects.

Rich in Manuka Honey: Known for its antibacterial and healing properties, this ensures wounds recover faster. Xtrasorb® – the best in the list of wound care dressings. Product review.– the best wound absorbent dressing. It is recommended to be used after applying Medihoney or Activon, or other medical grade honey you have. This cover dressing will ensure the safety of the wound, while absorbing and retaining the fluid, even under exterior pressure. Synergistic effects of sub-inhibitory concentrations (<8% w/v) of manuka honey (Comvita, Ltd) and rifampicin on S. aureus biofilm formation and on established biofilms have also been observed in vitro. 24 , 30 Interestingly, some antibiotic combinations (clindamycin, gentamicin and oxacillin) showed an antagonistic effect on S. aureus established biofilms when the honey was used at sub-inhibitory concentrations but not at higher honey concentrations above the MIC (eg, 16% w/v). Physiological and metabolic differences in bacteria within a biofilm could impair the ability of sub-inhibitory concentrations of honey in combination with antibiotics to kill the bacteria. Discomfort can be experienced when honey is applied, depending on sensitivity of the wound it may be necessary to consider an appropriate level of analgesia. The initial discomfort usually subsides, however if it does continue, discontinue use and irrigate the wound with saline solution. How to Use Versatile Applications: Ideal for necrotic tissue and dressing top up. U seful for application into abscesses or cavity wounds.Activon honey is a medical grade honey for wounds, produced by Advancis Medical from manuka honey, New Zealand. When shall we use it?