Tris NAC is designed with Tris EDTA and N-acetyl cysteine for managing bacterial ear and skin issues in dogs and cats that resist usual treatments. Pye C, Yu A, Weese JS. Evaluation of biofilm production by Pseudomonas aeruginosa from canine ears and the impact of biofilm on antimicrobial susceptibility in vitro. Vet Dermatol. 2013;24:446–449. Ear canal: Squeeze the solution into the ear canal, then cover the ear with the ear flap and gently massage the base of the ear. Leave for 3–5 minutes and remove any excess with a cotton wool pad. Topical therapy is preferred wherever possible. Systemic antimicrobial therapy may be less effective in erythroceruminous otitis externa as bacteria are present only in the external ear canal and cerumen. Systemic treatment may be more useful in suppurative otitis externa and/or otitis media where there is an inflammatory discharge with concurrent tissue infection. Systemic treatment is indicated when the ear canal cannot be treated topically (e.g., stenosis, compliance problems or topical adverse reactions) and in otitis media. Antimicrobial susceptibility tests do not predict the response to topical treatment. The susceptibility and resistance breakpoints are based on tissue levels following systemic dosing. A resistant result applies to the infection; this does not necessarily mean that the bacteria are resistant to the antimicrobial, as the high levels following topical treatment frequently exceed the MIC. Antibiotic sensitivity data can be used to predict the efficacy of systemic drugs, although penetration to the ear tissues is often low and high doses are needed.

Marine exopolysaccharides (EPS) — These natural polymers have excellent moisturizing properties and are used in human cosmetics for their softening effects. Tris-NAC — Tris-N-acetylcysteine is a mucolytic that can be used in the ear or on the skin to prevent biofilm formation and to disrupt mature biofilm. Once mixed and activated, the product is effective for 50 days.Poor compliance or adherence will compromise efficacy and encourage resistance. This can be improved by: Triz-EDTA can also be used for preventing the recurrence of ear infections caused by Pseudomonas and other bacteria by using it as part of a regular ear cleaning regimen. It can be particularly useful for dogs which are predisposed to recurrent otitis (e.g. dogs with chronic disease like atopy, idiopathic seborrhea). TrizEDTA damages bacterial cell walls and increases antibiotic efficacy. It is best given 20–30 minutes before the antibiotic but can be co-administered. It is well tolerated and non-ototoxic. It shows additive activity with chlorhexidine, gentamicin and fluoroquinoles. Solutions of 0.6% enrofloxacin, 0.2% marbofloxacin, 0.3% gentamicin, 0.1% amikacin, 2.8% ticarcillin and 1.7% ceftazidime in TrizEDTA are effective against many multi­drug resistant bacteria including Pseudomonas. Contains witch hazel extract, tea tree oil, organic mullein leaf extract, rosemary extract, and fingerroot extract Nearly all ear infections involve commensal (e.g., staphylococci and Malassezia) or environmental (e.g., Pseudomonas) opportunists. The vast majority are secondary to pre-existing inflammation, foreign bodies, obstruction or other primary problems. Ongoing inflammation leads to a cycle of recurrent infection and chronic inflammation leading to progressive pathological changes and end-stage otitis. The chronic inflammation makes each bout of infection harder to treat and repeated antimicrobial use may select for resistance.

Most liquid dog ear cleaners are fairly simple to use, but be warned—ear cleaning can get messy. So, you might want to clean your pup’s ears in a bathroom or outside.

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Borriello G, Paradiso R, Catozzi C, et al. Cerumen microbial community shifts between healthy and otitis affected dogs. PLoS ONE. 2020;15(11):e0241447. doi: 10.1371/journal.pone.0241447

If your dog has extremely dirty ears, the instructions recommend applying 2-3 times daily over several days This article is part of the Behind the Design series published in the 2022 Clinic Innovation Guide. This article explores the design process for ICF products by Nextmune, from the perspective from a key leader in the process.

Unfortunately, ear infections in dogs are pretty common. If left untreated, they can get really bad, spreading to the inner ear and putting your dog at risk for deafness, facial paralysis, eye issues, or worse.

Innovative and synergistic sterile solution that combines NAC and Tris-EDTA. Suitable for dogs and cats.

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Polymixin B, fusidic acid, florfenicol, gentamicin, enrofloxacin and marbofloxacin are suitable for most bacterial infections. Polymixin B and miconazole have synergistic activity against Pseudomonas and other gram-negative organisms, and fusidic acid and framycetin show synergistic activity against staphylococci. Fluoroquinolones, gentamicin and polymixin B are usually effective against Pseudomonas. Fusidic acid and florfenicol are effective against MRSA and MRSP. Neomycin is less potent that other aminoglycosides, although it is usually effective against gram-positive bacteria. It is important to use an adequate volume - 1 ml is sufficient for most ears.