Following the data announcement, Shahram Attarian, MD, PhD, head of the Neuromuscular Diseases Service and ALS Department at Timone Hospital in Marseilles, France, said in a statement that “as an investigator involved since the beginning in the clinical development of PXT3003 in CMT1A, I find these long-term safety and efficacy data very encouraging. Being able to stabilize, or even improve, patients with CMT1A is an extremely worthwhile goal, particularly as these individuals will inevitably decline following the long-term natural course of the disease with the currently available standard of care.” 3 Attarian, who served as lead investigator for PLEO-CMT and PLEO-CMT-FU, currently serves as lead investigator of the PREMIER trial. REFERENCES Note: On the 15/01/2015 Sony released PSP firmware 6.61, some three and a half years after the last 6.60 update. It's of no benefit to you updating to 6.61 after all this time, however the custom firmware has now been updated to support 6.61. So you can now follow this guide if you happen to have updated to 6.61.

If the firmware is permanently installed it means your PSP will boot directly in to the custom firmware when powered on, if not it means you will have to enable it again by launching a simple app. This however only needs doing from a cold boot, if you leave the PSP in standby like most people do (you probably do this without realising) then you will not need to enable it. bbtgp, Dark_AleX, Noobz, Team C+D, M33 Team, and coyotebean for their new psardumper source to get the OFW binary

In PLEO-CMT, a revised statistical analysis plan was developed to consider the high amount of missing data because of the discontinuation of patients in this treatment arm. At the trial’s end, both high- and low-dose PXT3003 groups demonstrated decreased scores on the ONLS, indicating disability improvement, whereas those receiving placebo had worsening disability progression. The change in ONLS score was greatest in the high-dose group, for which the mean effect was –0.37 points ( P = .008). Between the low-dose and placebo groups, the mean effect was not statistically significant ( P = .287). You will be presented with lots of information about your PSP, the screenshot below is from my PSP 1000: VirtuousFlame: For the ISO Loading Code, Custom PSX EBOOT Support and most of the CFW related code. PXT3003 (PHARNEXT SA), a novel fixed-dose synergistic combination of baclofen, naltrexone, and sorbitol, is being evaluated in the pivotal phase 3 PREMIER study (NCT04762758) of patients with Charcot- Marie-Tooth disease type 1a (CMT1A), a neurological disease for which there are no curative or symptomatic medications approved. The international, randomized, double-blind, 2-arm, placebo-controlled trial is taking place in 52 centers across the United States, Canada, Europe, and Israel, with topline data expected to be announced in Q4 2023. 1 After running the update press "X" and the custom firmware will install, all been well your PSP will now be running custom firmware until you power it off.

I have personally tested and made this firmware permanent on my PSP 1000 and a friends PSP 2000 (Non 88v3). If you are unsure about anything just use the PROUPDATE and enjoy custom firmware. If you ever power your PSP off fully just use the fast recovery program, there is little risk to your PSP doing this.Attarian S, Young P, Brannagan TH, et al. A double-blind, placebo-controlled, randomized trial of PXT3003 for the treatment of Charcot-Marie-Tooth type 1A. Orphanet J Rare Dis. 2021;16(1):433. doi:10.1186/s13023-021-02040-8 There are 2 options for permanent CFW for the 2000 model. You can use cIPL flasher or use Infinity 2.0. CIPL flasher was meant for only 1000 and some 2000 models. Please read carefully below on how to determine if cIPL Flasher or Infinity 2.0 should be used. Pharnext announces on-schedule completion of patient enrollment in its pivotal phase III trial of PXT3003, the PREMIER trial, for the treatment of Charcot-Marie-Tooth disease type 1a. News release. Pharnext SA. May 30, 2022. Accessed July 11, 2022. https://pharnext.com/en/press-releases/pharnext-announces-on-schedule-completion-of-patient-enrollment-in-its-pivotal-phase-iii-trial-of-pxt3003-the-premier-trial-for-the-treatment-of-charcot-marie-tooth-disease-type-1a CMT1A, the most common form of CMT, is caused by a duplication of the PMP22 gene that is responsible for the production of the peripheral myelin sheath protein. Its duplication leads to abnormal levels of PMP22 protein, which then leads to a failure in the production of normal myelin. In data from preclinical studies, PXT3003 was shown to suppress PMP22 production and improve neuromuscular function. Dark_Alex for the initial M33 CFW who guided us mentally through several CFW generations by giving good examples on how to patch Sony OFW.

The PSP 1000 is able to have permanent custom firmware installed via cIPL flasher. cIPL (custom IPL) installs to the nand and allows the PSP to load the custom firmware files on boot. This is the preferred method for this model over installing Infinity. Infinity itself isn’t custom firmware but an exploit that allows PRO or LME to be enabled permanently. You are free to use whatever method you prefer but this guide suggests cIPL. As for ME and PRO, you can choose whatever one you want. Both are very similar in what features they offer and you can uninstall and try the other one if you are curious. For the sake of this guide, I personally use ME and find that the plugin manager a helpful feature which isn’t included in PRO. After showing a change of –0.11 in ONLS score at 15 months, patients in the high-dose PXT3003 group had an additional mean improvement of –0.17 in the following 45 months. The low-dose group didn’t see as much efficacy signal, but still had improvements of –0.17 in ONLS score in the final 45 months of treatment, following a –0.05 change seen at the 15-month mark. Notably, among patients receiving placebo in the original 15-week period who then switched to low-dose or high-dose PXT3003 during period 1 and high dose during period 2, the mean change in ONLS score was –0.11 in the final 45 months compared with a worsening change of 0.17 in the original 15-week treatment period. The system connects to the network using an access point. If you do not have a connection saved, select [New Connection] to create a connection.We can see that my PSP is a 1.2 the 1 been a PSP 1000 and it has a 79 V3 motherboard, which is capable of having custom firmware permanently flashed to it. Unzip and copy the program to your PSP > Game folder like you did with the custom firmware installer, then load PSP Ident up on your PSP: