Combats neurodegenerative disease via improvement of cognitive function, daily living activity, and global clinical assessment in participants with Alzheimer’s disease (230). Supports antioxidant function via decreased inflammatory cytokines (inflammation), decreased reactive oxygen species, and increased l-glutathione production (master antioxidant) (182,183). From another location the History trunk thought has a sub thought called History, which in turn has one called Mysteries (ancient civilizations etc). There’s some fun stuff there for sure. What is interesting is that there are thoughts that then sit in Mysteries and also Conspiracy Theories. Subtle connections start to appear after such a critical mass of thoughts and previously unconnected information finds common context from completely different starting points. The outpouring of ideas at these junctions is part of the immense power of human augmentation that PB enables and is extremely difficult to generate otherwise. Supports immune function, cognitive health, cardiovascular health, and bone health (204,205,206,207,208) Supports increased nitric oxide production, reduces blood pressure, reduces DNA damage, increases collagen production, increases bone strength, and aids as a neuroprotective agent (31).

Persistent Blake's pouch cyst:During embryogenesis, Blake's pouch is an inferior protrusion of the fourth ventricle. Blake's pouch results from a finger-like expansion of the posterior membranous area.It initially does not communicate with the subarachnoid space but later becomes a permeable structure and then constitutes the foramen of Magendia. [5] Formation of the cisterna magna is completed within the leptomeninges at the end of the 7th gestational week. Anatomically, the cisterna magna occupies the vallecula cerebelli, a depression between the medial aspect of the cerebellar tonsils and the inferior surface of the vermis. [6] Precursor for acetylcholine (neurotransmitter) which activates receptors in the central nervous system-mediated immune responses (α7nAchR) (64). Reduces prevalence of short-term memory loss in ADHD patients improved prefrontal cortex (PFC) pyramidal cells function (228).

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Supports Cardiovascular health via reduction of systolic BP, LDL, and inflammatory biomarkers (224). These capsules from Doppelherz® aktiv contain a unique combination of the omega-3 fatty acids EPA and DHA, ginkgo leaves extract, B-vitamins and vitamin E. Vital for regulation of gene expression, cell cycle progression, and DNA repair, and cell death (9).

Ginkgo leaves have long been considered in Asia as a mental stimulant. This is likely because ginkgo contains secondary metabolites that act on the vascular system to stimulate peripheral blood flow. Proper irrigation of the brain with oxygen-rich blood is a key determinant to keep good learning and cognitive abilities. Supports antioxidant function via reduced levels of reactive oxygen species and inflammatory markers (interleukin 6) (222). Persistent Blake's pouch cyst results when there is failed permeabilization.Persistent Blake's pouch cyst radiographically may have a similar radiographic appearance to mega cisterna magna, appearing as a cystic posterior fossa mass that matches CSF density on CT imaging and CSF intensity on MRI imaging. In contrast to mega cisterna magna, persistent Blake's pouch is characteristically associated with hydrocephalus. Similar to mega cisterna magna, persistent Blake's pouch cyst is not associated with cerebellar hypoplasia. Persistent Blake's pouch cysts are not associated with other brain abnormalities. Posterior fossa epidermoid cysts usually arise in the lateral subarachnoid cisterns.Epidermoid cysts may be difficult to distinguish from mega cisterna magna on computed tomography (CT) and head ultrasound as they both match CSF signal density and echogenicity, respectively. Similarly, on MRI, mega cisterna magnas and epidermoid cysts will match CSF signal intensity. Lifelong choline supplementation may combat neurodegenerative diseases by reducing amyloid-β plaque load (plaques of degrading neurons) (62).

No specific treatment is necessary for patients with incidentally discovered mega cisterna magna. Medications may treat associated signs/symptoms that may or may not be directly related to the mega cisterna magna, including headache, seizure, or psychiatric illness. The most used are the Portfolio thoughts that are the door ways to specific projects. I have 42 Portfolio thoughts and 19 of them are currently in use. My physical library of books, documents etc also then reflect those Portfolios, so in effect the structure of my brain is reflected in the structure of my physical data. Each Portfolio project is then jump-linked to various reference and study thought sections Niacin reduces the prevalence of neurodegenerative pathologies by preventing mitochondrial dysfunction (9). Mega cisterna magna refers to a cystic posterior fossa malformation that is characterized by an enlarged cisterna magna, absence of hydrocephalus, and an intact cerebellar vermis. It must be differentiated from persistent Blake’s pouch cyst, posterior fossa cysts, Dandy-Walker variant, and posterior fossa neoplasia. The mega cisterna magna is hypothesized to develop embryologically from the permeabilization of Blake’s pouch. Mega cisterna magna is typically an incidental radiographic finding but may be associated with certain psychiatric conditions, and in smaller studies, patients have performed inferiorly on specific cognitive functioning, including memory, executive functioning, and verbal fluency. There is no specific treatment or necessary surgical intervention for patients with incidentally discovered mega cisterna magna. This review article summarizes the embryology and relevant anatomy and describes the radiographic appearance of the mega cisterna magna and how it can be differentiated from similar diagnoses; it provides a framework for members of the interprofessional team. Vital for lymphocyte (immune cell) proliferation (growth) and paramount in neutrophil (immune cell) destruction of bacteria (18).

Studies on outcomes in patients with mega cisterna magna are limited and conflicting. In an older study identifying 14 cases of isolated mega cisterna magna out of 1,260 reviewed CT scans, long-standing neurologic dysfunction was reported in 57% of patients (8/14). [13] Supports healthy information by decreasing c-reactive protein (inflammatory markers) in the body and increasing insulin sensitivity (75,76).As an expert in health education, Hill has appeared-along with her MEGA exhibits-on national television, including on the Dr. Oz show and The Doctors show. She debuted her MEGA Lungs on the Dr. Oz show. Hill is regularly quoted in the media, and her exhibits are sought out by clients such as hospitals, foundations, associations and schools across the globe. Supports sexual health via increased activity of Vitamin D receptor activity of testosterone production (79). I would say the biggest impact is the shear volume of information I have at my fingertips and the speed at which I’m able to retrieve deep connections and information. It affects the way I think and organize and I do believe lays the foundation for future interfacing and semantic technologies. As the state of the art of artificial intelligence increases I believe my brain file will form the kernel of my own self aware neurally connected personal cloud. But that’s for another conversation… :) There is a limited role in surgical intervention, which may include CSF diversion for the treatment of hydrocephalus. However, if hydrocephalus is present, the diagnosis of mega cisterna magna should be questioned. Other surgical interventions include suboccipital craniectomy, with the surgical exploration of 2 patients in an early study without relief of patient symptoms. [8]

Supports cardiovascular health via reduced atherosclerosis, inhibiting lipid peroxidation, and improved endothelial vascular function (31).

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Supports immune health via neutralizing free radicals and reactive oxygen species, and increased T lymphocyte-mediated immune function (204). Pilocytic astrocytoma:Pilocytic astrocytomas account for approximately 15% of central nervous system (CNS) tumors and are the most common pediatric brain tumor. [10]Pilocytic astrocytomas may arise in the cerebral hemispheres, brainstem, spinal cord, and chiasmatic/hypothalamic region but tend to arise in the cerebellum. [11]