Plate diffusion test. Antibacterial activity against E. coli DH5α demonstrated on seeded agar plates by different antibiotics is indicated by clear zones where growth inhibition has occurred. Freshly grown E. coli cells (OD 600 = 0.2, 300 µL) were embedded in 20 mL warm agar in a Petri dish (diameter 9 cm). Afterwards, holes (diameter 0.6 cm) were punched out and filled with 40 µL of antibiotic solution at the mM concentrations indicated. Pictures were taken after 24 h of incubation in the presence of the antibiotics. ( A) kanamycin; ( B) allicin; and ( C) ampicillin. Alliinase is inactivated by the acidic pH of the stomach, so garlic tablets are usually enteric-coated to keep them from dissolving before they reach the small intestine. One study found that, unexpectedly, enteric coated tablets actually didn’t provide more bioavailable compounds compared to those that were not coated. Dosage According to Oregon State University, “Although powdered garlic supplements do not actually contain allicin, the manufacturer may provide a value for the ‘allicin potential’ or ‘allicin yield’ of a supplement on the label.” Use of Natural Products by Children : What the Science Says. NCCIH. https://www.nccih.nih.gov/health/providers/digest/use-of-natural-products-by-children-science

to Know about Allicin before Taking a Supplement What You Need to Know about Allicin before Taking a Supplement

Borghi C, Cicero AF. Nutraceuticals with a clinically detectable blood pressure-lowering effect: a review of available randomized clinical trials and their meta-analyses. Br J Clin Pharmacol. 2017;83(1):163-171. doi:10.1111/bcp.12902 Allicin showed promising activity both in vitro and in vivo against many plant-pathogenic fungal species, including pests, which are of economic importance. For example, Botrytis cinerea, Plectospherella cucumerina, Alternaria brassicicola and Magnaporthe grisea were strongly inhibited in vitro by allicin in fresh garlic juice in a plate-diffusion assay using spore-seeded agar [ 39]. In further studies, seed-disinfection turned out to be an efficient and potential application of allicin. It was shown that carrot seeds, infected with Alternaria spp., were disinfected by treatment with garlic juice in a degree comparable to a commercial seed-disinfection product [ 1]. In another assay, germination and seedling-development of pathogen-infested wheat seeds were enhanced by treatment with garlic juice [ 56]. Thus, allicin seems to have a potential in seed-disinfection programmes both in ecological agriculture and under low-tech conditions (like in developing countries). Since allicin is easy to obtain from freshly damaged garlic tissue, applications in that direction would allow a plant-protection strategy according to the maxim “ grow your own pesticide”. The global effects of allicin on the yeast transcriptome were reported by Yu et al. [ 69]. From micro-array experiments it was determined that allicin impaired the expression of genes coding for enzymes of amino acid metabolism (methionine, in particular), iron-uptake, the respiratory chain, thiamine-metabolism and proteasomal protein degradation [ 69]. The authors postulated that these results might be explained by the action of allicin on several different yeast transcription factors (YAP1, MSN2/4, RPN4, SKN7) ( ibid.).

Allicin As an Alternative to Antibiotics

Ajebli M, Eddouks M. Phytotherapy of Hypertension: An Updated Overview. Endocr Metab Immune Disord Drug Targets. 2020;20(6):812-839. doi:10.2174/1871530320666191227104648 It is no wonder that hospitals are now buying allicin to put on feeding tubes, catheters, etc. as a means of preventing infection! 6 A 2013 meta-analysis found that garlic preparations significantly lowered total cholesterol and low-density lipoprotein (LDL)-cholesterol compared to placebo among adults with elevated cholesterol. Plants may seem defenseless when it comes to warding off pests, rodents and other predators, but they in fact have a secret weapon: pungent smells and tastes in the form of phytochemicals, which sometimes are toxic to small creatures when ingested. Allicin, produced inside raw garlic cloves, is an example of a compound that has these effects.

AllicinMax 180 Capsules (Food Supplement) - Modern Herbals AllicinMax 180 Capsules (Food Supplement) - Modern Herbals

Sometimes up to 2,400 mg/per day may be taken. This amount can typically safely be taken for up to 24 weeks.Haghi A, Azimi H, Rahimi R. A Comprehensive Review on Pharmacotherapeutics of Three Phytochemicals, Curcumin, Quercetin, and Allicin, in the Treatment of Gastric Cancer. J Gastrointest Cancer. 2017;48(4):314-320. doi:10.1007/s12029-017-9997-7 There is a link between the functioning of the immune system and cancer. In an early study (1960), explants of mouse-tumours were incubated in allicin before implantation into healthy mice. In contrast to the control group (where the explants were not allicin-treated), mice with tumour explants incubated in allicin showed no further growth of the explant [ 102].

AllicinMAX - 180 Capsules - Allicin International | Amrita

Ribeiro M, Alvarenga L, Cardozo LFMF, et al. From the distinctive smell to therapeutic effects: Garlic for cardiovascular, hepatic, gut, diabetes and chronic kidney disease. Clinical Nutrition. 2021;40(7):4807-4819. doi:10.1016/j.clnu.2021.03.005 Compounds created by allicin are considered to be very volatile. They give off hydrogen sulfide, the reason they are so pungent.Doma K, Devantier-Thomas B, Gahreman D, Connor J. Selected root plant supplementation reduces indices of exercise-induced muscle damage: s systematic review and meta-analysis. Int J Vitam Nutr Res. 2020;1-21. doi:10.1024/0300-9831/a000689 There are numerous compounds in garlic which are responsible for these health benefits, but researchers have pinpointed one in particular for its outstanding health benefits: allicin. Unfortunately though, getting the health benefits of allicin isn’t as easy as popping a garlic supplement. A single garlic clove has about 5 to 18mg of allicin. 5 In the studies which found health benefits of allicin, much higher amounts of allicin were used. No, but it's considered by many people to be one of the best natural antibiotics available right now.Supplementing with Allicin Maxmayhelp with Heart & Cardiovascularhealth, diabetes, andatherosclerosis.Just 1-2 capsules a day ( at mealtimes) should provide enough allicin for your general health and well-being. However you can take up to 10 capsules per day if required. What makes Allicin Max stand out? The enzyme allinase converts alliin (a derivative of the amino acid cysteine) into allicin. It is allicin which gives garlic its strong aroma. This strong aroma keeps pests away, and also has antibacterial and antifungal properties to protect the plant from infection.

Allicin Max | Garlic Capsules to Support the Immune System

Bat-Chen and co-workers, for instance, showed that Nrf2 is involved in allicin-induced apoptosis [ 106]. This reveals the “Janus face” of Nrf2 [ 107]: While Nrf2 is mostly described as an anti-apoptotic factor regulating the expression of anti-apoptotic proteins of the Bcl-2 family like Bcl-2 and Bcl-xL [ 108, 109], Nrf2 also seems to have a pro-apoptotic function under certain circumstances ( ibid.). Also the ERK1/2 map kinases were shown to be influenced by allicin in immune cells; these kinases are also important for apoptosis induction by allicin [ 103, 110]. Allowing crushed garlic to stand for 10 minutes before being cooked may help increase levels and some biological activity. However, it’s debatable how well this compound can withstand its journey through the gastrointestinal tract once eaten. Another central regulator of a coordinated immune-response is the TNFα cytokine [ 97]. Impairment of TNFα secretion massively influences the regulation of the immune-response. For that reason it is interesting that allicin inhibits the release of TNFα-dependent pro-inflammatory cytokines in intestinal epithelia [ 98]. This, however, reflects an effect of allicin on factors downstream of TNFα. Since TNFα is mainly secreted by macrophages [ 99], the effect of allicin on macrophages was examined with respect to how allicin influences the expression of TNFα itself. It is interesting that a stimulation of macrophages by lipopolysaccharide (LPS) after a pre-incubation in the presence of allicin enhances the activity of the TNFα promoter, suggesting a TNFα-triggering role for allicin in LPS-stimulated cells [ 100]. Furthermore, allicin inhibits phosphatase-activity, correlating with an enhanced phosphorylation of ERK1/2 ( ibid.), which is a central component of the signalling cascade transferring extracellular signals into intracellular signalling cascades. Furthermore, the release of Reactive Nitrogen Species (RNS) by LPS-stimulated macrophages was suppressed by allicin [ 100, 101].

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Majewski M. Allium sativum: facts and myths regarding human health. Rocz Panstw Zakl Hig. 2014;65(1):1-8.