The same team undertook a preliminary clinical study of 10 women, persistently infected with high-risk HPV, that was encouraging enough to lead to a larger clinical trial. Smith is now undertaking a NIH-funded, double-blinded, placebo-controlled study of 50 women with persistent high-risk HPV infection with results expected to be published by 2021. Women must have had 2 other HPV-positive tests with normal/negative cytology, atypical cells, ASCUS, or CIN1 or CIN2 cervical dysplasia The original contributions presented in the study are included in the article/supplementary materials. Further inquiries can be directed to the corresponding author. Ethics Statement POTENCY. 100% natural Mushroom Complex 6 MAXIMUM STRENGTH is an equal mix of six different mushrooms, Chaga, Cordyceps, Shiitake, Reishi, Lions mane and Maitake giving a diverse, high potency, complete mushroom formula.

This was the first double-blind, placebo-controlled clinical study to demonstrate that the nutritional supplement, AHCC, is effective in eliminating persistent, high-risk HPV infections with durable response in those patients who achieved an IFN-β level below 20 pg/ml. Overall, AHCC was well tolerated and had comparable adverse effects as compared to placebo. REVOLUTIONARY ECO-FRIENDLY, PULLULAN CAPSULES. Many cheaper supplements use capsules made from plant cellulose which goes through heavy processing and produces non-environmentally friendly, harmful bi-products. Pullulan is the next generation in encapsulation, derived from tapioca and processed with water. MADE TO HIGH QUALITY GMP STANDARDS, 100% VEGAN WITH NO FILLERS, BINDERS OR ADDITIVES. We believe in clean nutrition which is why you won't find any nasty stuff in our products, unlike some of our competitors. UK MADE & HIGH QUALITY. This product is manufactured in the UK to GMP standards, ensuring the highest quality.AminoUp’s leading supplement, AHCC, was launched in 1987, following an evaluation of more than 100 different mushroom species, and systematically tested for optimized manufacturing. The proprietary, standardized extract of cultured Lentinula edodes mycelia, AHCC (Amino Up Chemical Co. Ltd, Sapporo, Japan), was developed in Japan in 1992. Several studies have reported a variety of therapeutic effects, including antioxidant and anticancer activity and improvement of immune response ( 9, 10). In animal studies, AHCC has shown the ability to treat and prevent cancer, and modulate the immune system to prevent infectious processes ( 9– 11). Gao et al. demonstrated the immunomodulating effects of AHCC in a study that showed enhanced antigen (Ag) activation of CD4 (+) and CD8 (+) T cells, and the increased frequency of tumor Ag-specific IFN-gamma producing CD8 (+) T cells as well as increases in cell numbers of NK cells and gamma delta T cells ( 10). In clinical studies AHCC has demonstrated benefit to decrease risk of infection and ameliorate symptoms of existing infections ( 9– 11, 13). Since studies have demonstrated AHCC induces apoptosis ( 12– 14), it is possible that AHCC may also prevent/delay tumor growth regardless of the role of HR-HPV. A) AHCC 3g supplementation (B) AHCC 1g supplementation. IFN-β is a Type-1 IFN often associated with virulence of chronic viral infections. Chronic viral infections are often associated with high levels of IFN-β that leads to suppression of the production of IFN-γ and NK/T-cell cytotoxic cell immunity. It was observed in both pilot studies AHCC supplementation suppression of host IFN-β levels below level of 25 pg/mL that lead to modulation of the cytotoxic cell immunity to a successful, durable clearance of persistent, high risk HR-HPV infections. All patients enrolled were included in safety analysis for adverse events. Overall, no study patients reported greater than grade 1 toxicity on either placebo or the AHCC supplement arm. AHCC was well tolerated compared to placebo.

The presented bench-to-bedside research provides step-wise data to support the hypothesis that AHCC supplementation modulates host immune system, specifically via suppression of elevated IFNβ levels, to effectively clear chronic, persistent HR-HPV infections. After observing elimination of HR-HPV in vitro in the panel of human cervical cancer cell lines, animal studies were completed that also demonstrated successful, durable elimination of HR-HPV after completing AHCC supplementation. Finally, in two “proof of concept” pilot studies of daily AHCC supplementation successful elimination of HR-HPV was achieved that was durable response. Both the animal and human data suggests the mechanism AHCC supplementation supports the host immune system to clear HPV infections is attributed to the modulation of the expression and signaling of IFNβ that is known to be elevated in chronic viral infections (16, 17).

Also in our ADVANCED formula is Fucoidan from Wakame seaweed. This has been shown to work in synergy with the ingredients in this formula. There are some limitations to data presented. First, in the preclinical setting there is no established HR-HPV animal model which has also been a challenge for in the pre-clinical development of HPV vaccines. As a surrogate a human tumor infected with HR-HPV was employed to determine if the HR-HPV infection could be cleared with AHCC supplementation and was durable response after AHCC supplementation was stopped. In addition, in both the pre-clinical and clinical studies it would be ideal to confirm eradication with quantitative PCR methods as well as evaluate other immune markers such as CD8+ T-cells or natural killer (NK) cells but due to limited funding and being exploratory study, an exhaustive immune panel evaluation could not be completed. However, in the ongoing phase II confirmation study these studies are being evaluated. AminoUp has funded laboratory studies on mice that have further revealed that AHCC is effective at activating immune cells against West Nile virus, influenza, and avian flu. A clinical study in Nutrition Research suggests that supplemental AHCC may boost the antibody titre when given at the time of vaccination for influenza B. In conclusion, the results from this phase II study demonstrated that AHCC 3 g once daily was effective to support the host immune system to clear persistent HPV infections and was well tolerated with no significant adverse side effects reported. The duration of AHCC supplementation required beyond the first negative result needs more evaluation to optimize durable outcomes based on both HPV infection status and the target IFN-β level. Data Availability Statement

In traditional Chinese medicine, mushrooms have been used to modify immunity,” says Dr Kohei Homma, AminoUp’s executive senior director of business development. “Our research scientists were motivated to understand the immunological benefit of mushrooms.”This study was supported by the NIH-NCI Small Grants Program for Cancer Research (1R03CA212935), which had no involvement in the study design, data collection, data analysis, and interpretation or writing of the manuscript or its publication. Conflict of Interest Fucoidan from Wakame seaweed is the most trusted source of Fucoidan available and has been researched and proven in promoting a huge array of health benefits. Brown seaweeds that are rich in Fucoidan have long been eaten each day as part of the Okinawan Diet; a Japanese island that has the longest life expectancy of any native population. If you have problems sleeping or experience digestive issues with this product you are taking too much. Reduce the dose to one capsule per day to let your body get used to the product and gradually build up to the required dosage. Everyone is different and whilst some people can take 6 capsules in one dose, others with sensitive digestive systems need to take their time and build up to the required dose. IMPORTANT: If this is your first time taking this product, you may want to start with half a capsule per day for a short while. We recommend starting on the lowest possible dose and gradually increasing as your body gets used to it.

EXTRACTED, 3RD PARTY TESTED. Alcohol and hot water extraction techniques are used to draw out both the water-soluble and the non-water-soluble bio actives. Many supplement companies claim their products are 3rd party tested but are vague about what is actually tested for and often cannot provide supporting documents. Our Mushroom Complex 6 is 3rd party tested for both heavy metals and active compounds at 2 of Europe's top testing facilities, certificates available upon request. If you breach these conditions and we take no action, we will still be entitled to use our rights and remedies in any other situation where you breach these conditions. Governing Law and JurisdictionBENEFITS. Our High Strength Active Hexose Correlated Compound contains a potent mix of specially selected mushrooms to boost the immune system. Kentaro Kitadate, president and chief operating officer of AminoUp believes AHCC has the potential to support the health of an ageing population.