Effepharm has recently completed a multi-center, randomised, double-blind, parallel design, placebo-controlled study to evaluate the efficacy and safety of its Uthever NMN, which is manufactured in strict accordance with USP standards. A: We don’t know of any regulatory changes in any other countries that would cause NMN to be pulled from any foreign markets.

The Uthever Production Management Team is led by senior managers from Mars Wrigley, one of the world's largest food producers with numerous world-renowned brands. Wahab, A., Gao, K., Jia, C., Zhang, F., Tian, G., Murtaza, G., & Chen, J. (2017). Significance of Resveratrol in Clinical Management of Chronic Diseases. Molecules: A Journal of Synthetic Chemistry and Natural Product Chemistry, 22(8). During a meeting on Friday, Dan Fabricant, the head of the Natural Products Association (the NPA) explained that although everyone hopes the citizen's petition leads to an FDA policy reversal on NMN, the filing is meaningful regardless of the FDA's response because it will ultimately allow the trade organizations the right to sue the FDA. Now that the citizen's petition has been filed the FDA has 180 days to respond. Often, they don't respond to citizen's petitions, but in both the case of a denial of the petition or a non-response the NPA and ANH gain the legal right to sue.

Villarreal, G., & Zhang, Y. (2010). Activation of SIRT1 by resveratrol induces KLF2 expression conferring an endothelial vasoprotective phenotype. Cardiovascular Research, 85(3), 514-519. Li, D., Tian, Y. J., Guo, J., Sun, W. P., Lun, Y. Z., Guo, M., Luo, N., Cao, Y., Cao, J. M., Gong, X. J., & Zhou, S. S. (2013). Nicotinamide supplementation induces detrimental metabolic and epigenetic changes in developing rats. The British Journal of Nutrition, 110(12), 2156–2164.

NMN Pro Complete is the first and only perfectly balanced combination of NMN, Trans-Resveratrol and TMG on the market. Instead of having to take three separate supplements each day, you can now get the ideal balance of all three in one convenient serving. This combination of ingredients provides what may be an ideal middle-ground dose for many people, with 500mg of NMN being strong enough to have a noticeable impact but weak enough to curb some of its associated risks. And 500mg of resveratrol is a similarly average dose, but if you’re concerned about its risk potential, you can take it with a high-fat breakfast, which will slow its absorption rate without affecting the extent of its absorption. 22 The closest product to this would be Wonderfeel’s Youngr, which offers a larger NMN dose (900mg) but a smaller resveratrol dose (100mg) for a noticeably higher price. While most of these products have similar ingredient profiles, a lot can happen during the manufacturing process that can potentially contaminate a supplement. There are also secondary and tertiary ingredients that can make one brand a better choice than another, whether they’re included for their own merits or to increase the bioavailability of each NMN dose. Renue By Science’s third-party testing promise gives it the win in safety, along with its limited ingredients and variegated delivery mechanisms. It allows an independent organization to verify the purity and safety of its products, and you can choose from a range including pure NMN powder and more complex formulas.It is anticipated that results of this largest and most comprehensive human clinical trial on NMN to date will be published in the near future. Additionally, ProHealth Longevity is conducting its own multi-center, placebo-controlled clinical trial, an unusual step for an ingredient wholesaler/retailer. ProHealth Longevity Nicotinamide mononucleotide (NMN) is a derivative of the B-vitamin niacin that dramatically improves health and longevity by serving as a precursor to NAD+, a compound that plays a crucial role in energy production, metabolism and gene expression in the body. When we boost NMN levels in the body, we can enhance the biosynthesis of NAD+ and alleviate symptoms associated with depletion of this crucial nutrient. NMN supplementation has been found to improve various parameters of health, including physical endurance and muscle strength, brain health, heart health, body weight and gene expression.

Be Aware of Fake NMN: Fraudulent companies are always attempting to out-price competitors by using NMN fake ingredients to gain market share, which is not fair to you, the consumer, or the reputable companies, like ProHealth that spends time and resources to ensure a safe and pure NMN product. Supplement Facts The proprietary blend in NAD+ Platinum contains TMG, quercetin, and resveratrol. Considering the fact that Gold contains 50mg of TMG, the 60mg dose within this proprietary blend either reduces the amount of TMG to make room for the other ingredients or provides pretty low doses of those added ingredients (even for a sublingual liquid). Tummala, K. S., Gomes, A. L., Yilmaz, M., Graña, O., Bakiri, L., Ruppen, I., Ximénez-Embún, P., Sheshappanavar, V., Rodriguez-Justo, M., Pisano, D. G., Wagner, E. F., & Djouder, N. (2014). Inhibition of de novo NAD(+) synthesis by oncogenic URI causes liver tumorigenesis through DNA damage. Cancer Cell, 26(6), 826–839.

ProHealth Bulk NMN Supplements

Liao, B., Zhao, Y., Wang, D., Zhang, X., Hao, X., and Hu, M. (2021). Nicotinamide mononucleotide supplementation enhances aerobic capacity in amateur runners: a randomized, double-blind study. Journal of the International Society of Sports Nutrition, 18, 54. You, Y., Gao, Y., Wang, H., Li, J., Zhang, X., Zhu, Z., & Liu, N. (2020). Subacute Toxicity Study of Nicotinamide Mononucleotide via Oral Administration. Frontiers in Pharmacology, 11.