Following topical application of tacrolimus ointment, tacrolimus is selectively delivered to the skin with minimal diffusion into the systemic circulation. Additional treatment for the restorative processes of superficial and deep wounds (abrasions, break injuries, burns, surgical wounds, decubital injuries and ulcers) of all origins. Clinical data have shown that tacrolimus concentrations in systemic circulation after topical administration are low and, when measurable, transient. In a photocarcinogenicity study, albino hairless mice were chronically treated with tacrolimus ointment and UV radiation. Animals treated with tacrolimus ointment showed a statistically significant reduction in time to skin tumour (squamous cell carcinoma) development and an increase in the number of tumours. It is unclear whether the effect of tacrolimus is due to systemic immunosuppression or a local effect. The risk for humans cannot be completely ruled out as the potential for local immunosuppression with the long-term use of tacrolimus ointment is unknown. Tratament adjuvant in procesele reparative ale ranilor superficiale si adanci (julituri, laceratii, arsuri, leziuni chirurgicale, escare si ulceratii), indiferent de originea lor.

Following repeated topical application of the ointment the average half-life of tacrolimus was estimated to be 75 hours for adults and 65 hours for children. Cicatridine® 30g cream can be used alone or in addition to Cicatridine® ova, in external application: Kατακλίσεις, Πρόσφατα και χρόνια έλκη, Εγκαύματα Ι & ΙΙ βαθμού, Επιφανειακές λύσεις του δέρματος, Εκδορές, Διασχίσεις. Επιδιορθώνει και αποκαθιστά ερύθημα και ερεθισμό κατόπιν χρήσης Laser αποτρίχωσης, Επιδιορθώνει και αποκαθιστά ερεθισμό κατόπιν επεμβατικών peeling προσώπου και σώματος. Median number of DEs requiring substantial intervention adjusted for time at risk (% of patients without DE requiring substantial intervention) momentul în care spray-ul este aplicat pe zona afectată, se formează două straturi. Stratul superior usucă secreția și sângele din rană, iar stratul inferior formează un film protector le suprafața plăgii. Cicatridina prospect – mod de utilizare

Cicatridina este un tratament adjuvant pentru refacerea pielii în caz de roșeață, răni superficiale sau chiar răni adânci. Acesta te poate ajuta să ai din nou o piele frumoasă, fără semne, chiar și după ce ai suferit un mic accident. Îl poți folosi oricând atâta timp cât nu ești alergic la vreunul dintre componentele sale. Patients who are responding to up to 6 weeks treatment using tacrolimus ointment twice daily (lesions cleared, almost cleared or mildly affected) are suitable for maintenance treatment. Tacrolimus is not metabolised in human skin, indicating that there is no potential for percutaneous interactions that could affect the metabolism of tacrolimus. courier κατά την παράδοση των προϊόντων(extra χρέωση 2,5 €). 2)Πληρωμή με χρεωστική - πιστωτική κάρτα ,σας οδηγεί σε ασφαλές τοποθεσία της Τράπεζας EUROBANK ,χωρίς καμία επιβάρυνση για εσάς. Vreti sa vedeti si Cicatridina Supozitoare sau Cicatridina Ovule Vaginale Compozitie Cicatridina Unguent

Exposure of the skin to sunlight should be minimised and the use of ultraviolet (UV) light from a solarium, therapy with UVB or UVA in combination with psoralens (PUVA) should be avoided during use of Protopic ointment (see section 5.3). Physicians should advise patients on appropriate sun protection methods, such as minimisation of the time in the sun, use of a sunscreen product and covering of the skin with appropriate clothing. Protopic ointment should not be applied to lesions that are considered to be potentially malignant or pre-malignant. P<0.001 in favour of tacrolimus ointment 0.1% (adults) and 0.03% (children) for the primary and key secondary endpoints Carefully clean the area of treatment before each application. Apply to the affected area by gently massaging the product on. If necessary, secure with a gauze. It is a good hygiene practice to wash your hands before and after the use of this medical device. In the fourth trial, approximately 800 patients (aged ≥2 years) received 0.1% tacrolimus ointment intermittently or continuously in an open-label, long-term safety study for up to four years, with 300 patients receiving treatment for at least three years and 79 patients receiving treatment for a minimum of 42 months. Based on changes from baseline in EASI score and body surface area affected, patients regardless of age had improvement in their atopic dermatitis at all subsequent time points. In addition, there was no evidence of loss of efficacy throughout the duration of the clinical trial. The overall incidence of adverse events tended to decrease as the study progressed for all patients independent of age. The three most common adverse events reported were flu-like symptoms (cold, common cold, influenza, upper respiratory infection, etc.), pruritus and skin burning. No adverse events previously unreported in shorter duration and/or previous studies were observed in this long-term study.The safety of CICATRIDINA ointment during pregnancy and lactation has not been proven. Therefore, it is recommended that you consult your doctor before using this product. Durata utilizarii depinde de evolutia simptomelor; daca este necesar, unguentul CICATRIDINA poate fi utilizat pentru lungi perioade de timp. As systemic exposure is low with tacrolimus ointment, the high binding of tacrolimus (>98.8%) to plasma proteins is considered not to be clinically relevant. Mai multe detalii despre produsele Cicatridina unguent și Cicatridina spray vom oferi în rândurile de mai jos. Continuă să citești! Ar fi bine să ai în permanență un astfel de produs în casă pentru că nu știi niciodată când te-ai putea răni. Despre Cicatridina

Data from healthy human subjects indicate that there is little or no systemic exposure to tacrolimus following single or repeated topical application of tacrolimus ointment. EDTA άλας δινατριούχο, ΒΗΤ, ιμιδαζοληδινύλιο ουρία, χλωρεξιδίνη διγλυκονική, λάδι σιλικόνης, σορμπιτόλη, γλυκερίνη, στεατυλική (21) ΟΕ, στεατυλική (2)ΟΕ, λάδι γλυκών αμυγδάλων, κετυστεαριλική αλκοόλη, λάδι βαζελίνης, νερό. the molecules of hyaluronic acid form a protective film in the skin and mucous membranes against micro-trauma.thanks to its structure, hyaluronic acid promotes hydration by trapping water molecules. It therefore creates an environment favorable to the tissue regeneration process. Toată lumea visează să aibă o piele de invidiat, însă micile accidente casnice, ne pot lăsa semne pentru tot restul vieții. The efficacy and safety of tacrolimus ointment in maintenance treatment of mild to severe atopic dermatitis was assessed in 524 patients in two Phase III multicentre clinical trials of similar design, one in adult patients (≥16 years) and one in paediatric patients (2-15 years). In both studies, patients with active disease entered an open-label period (OLP) during which they treated affected lesions with tacrolimus ointment twice daily until improvement had reached a predefined score (Investigator's Global Assessment [IGA] ≤ 2, i.e. clear, almost clear or mild disease) for a maximum of 6 weeks. Thereafter, patients entered a double-blind disease control period (DCP) for up to 12 months. Patients were randomised to receive either tacrolimus ointment (0.1% adults; 0.03% children) or vehicle, once a day twice weekly on Mondays and Thursdays. If a disease exacerbation occurred, patients were treated with open-label tacrolimus ointment twice daily for a maximum of 6 weeks until the IGA score returned to ≤2.