Price, A. L., Spencer, C. C. A. & Donnelly, P. Progress and promise in understanding the genetic basis of common diseases. Proc. Biol. Sci. 282, 20151684 (2015). Turley, P. et al. Multi-trait analysis of genome-wide association summary statistics using MTAG. Nat. Genet. 50, 229–237 (2018). Zhou, W. et al. Efficiently controlling for case–control imbalance and sample relatedness in large-scale genetic association studies. Nat. Genet. 50, 1335–1341 (2018). Chang, C.C. et al. Second-generation PLINK: rising to the challenge of larger and richer datasets. Gigascience 4, 7 (2015).

International Consortium for Blood Pressure Genome-Wide Association Studies. Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk. Nature 478, 103–109 (2011). de Lau, L.M. & Breteler, M.M. Epidemiology of Parkinson's disease. Lancet Neurol. 5, 525–535 (2006). Another factor that can be a great indication of product quality is the brand. Brands like Grangers are of course extremely well known, especially for Cleaning & Proofing. Also, Nikwax now seem to only sell the rubbish cream (comes in a tube rather than a tin and is very thin).Hayes, B. J., Bowman, P. J., Chamberlain, A. J. & Goddard, M. E. Genomic selection in dairy cattle: progress and challenges. J. Dairy Sci. 92, 433–443 (2008). CARDIoGRAMplusC4D Consortium. A comprehensive 1000 Genomes–based genome-wide association meta-analysis of coronary artery disease. Nat. Genet. 47, 1121–1130 (2015).

Leveraging family history data to disentangle time-varying effects on disease risk using lifecourse mendelian randomization Aitken, A. C. Note on selection from a multivariate normal population. Proc. Edinb. Math. Soc. B 4, 106–110 (1934). Here at Grangers, we’re incredibly proud to be a Bluesign® system partner. We were the first aftercare brand in the world to receive this accreditation in 2007 and this guarantees that our products are cleaner, safer and, more importantly, environmentally-responsible.Chan, G. et al. CD33 modulates TREM2: convergence of Alzheimer loci. Nat. Neurosci. 18, 1556–1558 (2015).

Munoz, M. et al. Evaluating the contribution of genetic and familial shared environment to common disease using the UK Biobank. Nat. Genet. 48, 980–983 (2016). Taimeh, Z., Loughran, J., Birks, E.J. & Bolli, R. Vascular endothelial growth factor in heart failure. Nat. Rev. Cardiol. 10, 519–530 (2013).

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That’s why we’ve pulled together this list of key factors for Grangers G-Wax below, to help you choose if it’s the right product for you and your budget. So, H.-C., Kwan, J. S. H., Cherny, S. S. & Sham, P. C. Risk prediction of complex diseases from family history and known susceptibility loci, with applications for cancer screening. Am. J. Hum. Genet. 88, 548–565 (2011). Nalls, M.A. et al. Large-scale meta-analysis of genome-wide association data identifies six new risk loci for Parkinson's disease. Nat. Genet. 46, 989–993 (2014).

You don’t need to worry about what water type you have when using Grangers. All our formulations perform the same regardless of hard or soft water. Genomes Project Consortium. A global reference for human genetic variation. Nature 526, 68–74 (2015). Of those waxes mentioned so far the Meindl Sport Wax is by far the softest but it does take some time to work it down into the leather. If you don't take this time you will end up with a pair of super powerful dust magnets as I found to my cost. The material the product is made from is often a sign of the quality for Cleaning & Proofing. Take a look at the product details over at Go Outdoors to get a feel for this. You may also come across oil waterproofing products. Just like the previous options, these types of products are specifically formulated for waterproofing. But, they come in oil consistency.G-WAX and Waterproofing Wax are both effective, reliable waxes that keep footwear dry and protected. G-WAX is a harder wax that is less pliable but will require fewer applications between wear. Waterproofing Wax is a supple wax that can be easily applied to boots, though more frequent coatings may be required between uses. Chen, W.-M. & Abecasis, G.R. Family-based association tests for genomewide association scans. Am. J. Hum. Genet. 81, 913–926 (2007).