Caution should be exercised to avoid excessive blood-pressure changes since response to treatment with metaraminol is very variable and the ensuing control of the blood pressure may prove difficult. Given the higher metabolite to parent drug ratio in younger children, a delayed respiratory depression as a result of high active metabolite concentrations in the 3-6 months age group cannot be excluded. Therefore, the use of BUCCOLAM in the 3-6 month age group should be limited for use only under the supervision of a health care professional where resuscitation equipment is available and where respiratory function can be monitored and equipment for respiratory assistance, if needed, is available. Following overdose with oral midazolam, vomiting should be induced (within one hour) if the patient is conscious or gastric lavage undertaken with the airway protected if the patient is unconscious. If there is no advantage in emptying the stomach, activated charcoal should be given to reduce absorption. Special attention should be paid to respiratory and cardiovascular functions in intensive care.

Insulin analogs and human insulin technically use the same conversion (1 Unit = 0.0347 milligrams) and are considered 'equipotent'. Carers should only administer a single dose of midazolam. If the seizure has not stopped within 10 minutes after administration of midazolam, emergency medical assistance must be sought and the empty syringe given to the healthcare professional to provide information on the dose received by the patient.After oromucosal administration midazolam is absorbed rapidly. Maximum plasma concentration is reached within 30 minutes in children. The absolute bioavailability of oromucosal midazolam is about 75% in adults. The bioavailability of oromucosal midazolam has been estimated at 87% in children with severe malaria and convulsions.

A second or repeat dose when seizures re-occur after an initial response should not be given without prior medical advice (see section 5.2). Syringes come in various sizes. The most common sizes are 1ml, 2.5ml and 5ml syringes, but you can get 10ml and larger syringes. Liquid medicine doses are often expressed in terms of millilitres or ml. The printed label on the bottle will provide instructions as to how much of the medicine should be given to your child.Although they both provide 'Vitamin A', they have different biological activities (i.e., potencies) regarding how much 'Vitamin A' they actually provide. Therefore, they have been standardized with International Units as follows: If you are using syringes to draw up and inject your insulin, it is vitally important to be sure you are using the correct ones to prevent dosing errors. Atorvastatin showed a 1.4-fold increase in plasma concentrations of intravenous midazolam compared to control group. Midazolam is almost entirely eliminated by biotransformation. The fraction of the dose extracted by the liver has been estimated to be 30-60%. Midazolam is hydroxylated by the cytochrome P4503A4 isozyme and the major urinary and plasma metabolite is alpha-hydroxy-midazolam. Following oromucosal administration in children the area under the curve ratio for alpha-hydroxy midazolam to midazolam is 0.46. Overdose of benzodiazepines is usually manifested by degrees of central nervous system depression ranging from drowsiness to coma. In mild cases, symptoms include drowsiness, mental confusion and lethargy, in more serious cases, symptoms may include ataxia, hypotonia, hypotension, respiratory depression, rarely coma and very rarely death.

In the management of overdose with any medicinal product, it should be borne in mind that multiple agents may have been taken.Don't give your child's medicines to anyone else to use, even if they have the same symptoms as your child. They may be harmful to other people. Medical syringes are used for drawing up and expelling liquids or suspensions. They are designed to fit appropriate needles, tubing, syringe filters, or similar devices, and are constructed of plastic, glass, or a combination of both. They may also have metal components. In a population pharmacokinetic study, the metabolite levels are shown to be higher in younger than older paediatric patients and thus likely to be of more importance in children than in adults. Direct intravenous injection may be followed by an infusion of 15 - 100 mg in 500 mL of infusion liquid, using an appropriate metaraminol formulation and administration.