His mother, Lillian Murphy (née Laney, later Murphy Lynch), was a telephone operator, and his father, Charles Edward Murphy (1940–1969), was a transit police officer and an amateur actor and comedian. Murphy exchanged vows with film producer Tracey Edmonds, former wife of Kenneth "Babyface" Edmonds, on January 1, 2008, in a private ceremony on an island off Bora Bora. For Murphy's role as Donkey in Shrek (2001), he won the Annie Award for Outstanding Achievement for Voice Acting in a Feature Production and was nominated for the BAFTA Award for Best Actor in a Supporting Role for the latter, which to date the only voice-over performance to ever be nominated in BAFTA's history.

In September 2022 I made a drawing titled ‘hello again Lilibet’ as a reaction to the sad news of Queen Elizabeth passing away. In 2015, Murphy was honored with the Mark Twain Prize for American Humor, and in 2023 the Golden Globe Cecil B. Naming The Nutty Professor his favorite comedy, Rock regards Murphy's performance in the film as being so great he had "been robbed of an Oscar", adding his various performances were " Peter Sellers-esque". Several reviews for the film highlighted Murphy's performance while he received some pre-release Academy Awards buzz.

Murphy, who was credited as a "Strategic Guest Star", was added to the film after an original version was completed but tested poorly with audiences.

In 2021 when I had my youngest, I took some time off from commissions and started making and sharing more personal content. They lived together for almost two years before getting married at the Grand Ballroom of the Plaza Hotel in New York City on March 18, 1993.We also use them to help detect unauthorized access or activity that violate our terms of service, as well as to analyze site traffic and performance for our own site improvement efforts. in Coming to America, Dave Chappelle in The Nutty Professor, and Chris Rock in Beverly Hills Cop II. On July 9, 1976, the date with which Murphy marks the beginning of his career, he performed in a talent show at the Roosevelt Youth Center, doing an impersonation of singer Al Green as Green's song " Let's Stay Together" played. Most purchases from business sellers are protected by the Consumer Contract Regulations 2013 which give you the right to cancel the purchase within 14 days after the day you receive the item.