Often, increasing the amount of fibre in your diet (such as by eating more fruit, vegetables, cereals, and wholemeal bread) and drinking plenty of water each day can effectively prevent or relieve constipation. There was no evidence of any embryolethal, teratogenic or foetotoxic actions in rats or rabbits after oral treatment with sennosides. Furthermore, there was no effect on the postnatal development of young rats, on rearing behaviour of dams or on male and female fertility in rats. Data for herbal preparations are not available. Intestinal loss of fluids may promote dehydration. Symptoms may include thirst and oliguria. In patients suffering from fluid loss where dehydration may be harmful (e.g.renal insufficiency, elderly patients) Senokot Syrup Pharmacy should be discontinued and only be restarted under medical supervision. dihydroxyanthracene derivatives possess a laxative effect. The β-Ο-linked glycosides (sennosides) are not absorbed in the upper gut; they are converted by bacteria of the large intestine into the active metabolite (rhein anthrone).

the guidance ofa medical professional. Do not exceed the stated dose Senokot 7.5mg/5ml Syrup usually works in 8–12 hours. New users should start with the lowest dose and if needed increase by half the initial dose each day. When you feel the medicine is working, gradually reduce the dose and stop. This product should only be used if a therapeutic effect cannot be achieved by a change of diet or the administration of bulk forming agents. Duration of use: Normally it is sufficient to take this medicinal product two to three times a week. Use for more than 1 –2 weeks requires medical supervision. Tell a doctor, pharmacist or nurse if: – the symptoms worsen or persist during the use of the medicinal product – there is no bowel movement within 3 days ofuse – you need to take laxatives every day or if abdominal pain persists. Yellow or red-brown (pH dependent) discolouration of urine by metabolites, which is not clinically significant, may occur during the treatment. Sennosides displayed no specific toxicity when tested at doses up to 500 mg/kg in dogs for 4 weeks and up to 100 mg/kg in rats for 6 months.Drink plenty of fluids (6 to 8 glasses a day) while you're taking senna or your constipation may get worse. How long to take it for Take senna for a few days only and no longer than a week. If you take it for longer, your body can start to rely on it, rather than your bowels doing the work on their own. If you forget a dose of senna, just skip the missed dose and take the next dose the following evening. This medicine contains 6.9 mg of alcohol (ethanol) in each 5ml dose. The amount in each dose of this medicine is equivalent to less than 1 ml beer or 1 ml wine. As a result of investigations with parenteral application in mice, extracts are supposed to possess a higher toxicity than purified glycosides, possibly due to the content of aglyca.

You may wish to include some foods in your diet that contain sorbitol. Sorbitol is a naturally occurring sugar. It is not digested very well and draws water into your bowel which has an effect of softening stools. Fruits (and their juices) which have a high sorbitol content include apples, apricots, gooseberries, grapes (and raisins), peaches, pears, plums, prunes, raspberries and strawberries. You can read more about how to prevent or treat constipation in the separate condition leaflets called Constipation(for adults) and Constipation in Children. A 104-week study on rats of both genders did not reveal any carcinogenic effects with the same senna pods preparation at oral dosages of up to 300 mg/kg. It is important for you to drink plenty while you are constipated. Adults should aim to drink at least two litres (about 8-10 cups) of fluid per day. Most sorts of drink will do but, as a start, try just drinking a glass of water 3-4 times a day in addition to what you normally drink. If no bowel action has occurred after three days of progressively increased dosage, a medical examination should be considered.influence on secretion processes by two concomitant mechanisms viz. inhibition of absorption of water and electrolytes (Na+, Cl-) into the colonic epithelial cells (antiabsorptive effect) and increase of the leakiness of the tight junctions and stimulation of secretion of water and electrolytes into the lumen of the colon (secretagogue effect) resulting in enhanced concentrations of fluid and electrolytes in the lumen of the colon. Not to be used for more than 1 week. Usually it is sufficient to take this medicinal product up to two to three times during that week. A doctor may prescribe higher doses for adults and children up to a maximum of 4 tablets (30mg) taken once a day if necessary. Dosage for senna syrup prescribed by a doctor