Inflammation causes much of the discomfort associated with dry eyes and can lead to more severe conditions such as corneal ulcers. Dry eye is a condition where the surface of the eye becomes inflamed and sore due to a poor relationship between the tear film and the eyelids. Therapeutic efficacy of trehalose eye drops for treatment of murine dry eye induced by an intelligently controlled environmental system. Several studies prove that sodium hyaluronate can improve some types of ocular surface damage associated with dry eyes. If you’re looking for a way to reduce your dry eye symptoms, these eye drops might be able to provide you with the relief you need.

The study was approved by the Ethical Committee for Clinical Investigation of Navarre and was conducted according to the Declaration of Helsinki (2008) and Good Clinical Practice (GCP), European directive 93/42/CEE, and in accordance with ISO 14155:2011. As the bottle design is an integral part of the product conventional treatment, blinding was not possible. Patients were also required to be able and willing to give informed consent and to comply with the study protocol.Users should not disregard, or delay in obtaining, medical advice for any medical condition they may have, and should seek the assistance of their health care professionals for any such conditions. YHTEISVAIKUTUKSET: Silmään käytettävien eri valmisteiden annostelun välillä on pidettävä vähintään 10 minuutin tauko. Hyaluronate is a component of many medicinal preparations including those used in cataract surgery, for the treatment of dry eye as well as many commercial skin preparations and antiaging creams. Suositellaan erilaisiin silmäoireisiin, kuten epämukava tunne, pistely ja ärsytys, minkä syynä ovat ulkoiset tekijät.

Duo refers to the fact that these eye drops also contain sodium hyaluronate—a substance that is also used to manage dry eyes alone. Overall global efficacy was assessed by both patient and investigator at the end of each treatment period. The first half, Thealoz, closely resembles trehalose, a bioprotective found in several resilient desert plants. There are 3 ways to take Thealoz Duo and all are provided in either a drop form, gel form or single unit doses. Contact lenses are often a cause of dry eyes which is why Thealoz Duo only contains ingredients friendly to contact lens wear.Patient dry eye symptoms and impact on daily life, daily activities, impact on work, emotional impact, and ocular comfort were broadly similar between the groups at baseline, and all fell during the study ( Figure 2).

However if you use the gel please remove your contact lenses first and wait 30 minutes before re-inserting to allow the gel to work. To help reduce or eliminate these symptoms, Thealoz Duo works in several ways due to the active ingredients Trehalose (as in Thealoz) and Sodium Hyaluronic Acid (also known as Hyabak). Evaluation of protective effects of trehalose on desiccation of epithelial cells in three dimensional reconstructed human corneal epithelium. These larger studies established significant benefits of trehalose-containing eyedrops over saline and hydroxymethylcellulose eyedrops. Both treatments were administered as one drop five times daily in both eyes for 7 days followed by a washout period of 5 days, whereupon patients switched to the alternate treatment for 5 days.Thealoz Duo is a hypotonic formulation (low osmolarity), which means it particularly addresses the hyperosmolarity of the tear film in chronic dry eye to effectively soothe symptoms. Thealoz Duo ® was compared with an active control Systane ®, an established and effective treatment in dry eye. Sen vuoksi sillä voidaan normalisoida kuivasilmäiselle tyypillinen kyynelnesteen liian korkea suolapitoisuus ja palauttaa kyynelnesteen luonnollinen osmoottinen tasapaino. This might be because your eyes are not producing enough tears, or that the chemistry of the tear film is out of balance.

The primary endpoint was analyzed using a mixed-effects analysis of covariance, considering the patient within the sequence as a random effect and using the type III Sum of Squares for evaluation of the effect.Notes: The severity of conjunctival hyperemia rated using a photographic scale derived from McMonnies and Chapman-Davies. Thealoz Duo is one popular product that’s currently attracting a lot of attention—but how can you know whether these eye drops will be right for you? The following sections break down exactly how each of the two primary ingredients (Trehalose and Sodium Hyaluronate) in Thealoz Duo eye drops helps alleviate dry eye symptoms. Eye drops containing trehalose reduce inflammation and other symptoms resulting from hyperosmolarity, providing comfort for people with dry eyes and helping them find noticeable relief.