Bourgeois BF, Dodson WE, Ferrendelli JA. Interactions between primidone, carbamazepine, and nicotinamide. Neurology. Oct 1982;32(10):1122-1126. The tolerable upper limit of vitamin B3 is 35 mg per day. This is the amount least likely to cause flushing, redness, itching and tingling of your skin, a known side effect of nicotinic acid but not niacinamide ( 1, 29). There have been reports of minor side effects associated with nicotinamide, such as stomach discomfort, nausea and headaches.

NIACINAMIDE - Uses, Side Effects, and More - WebMD

A combination of oral nicotinamide and tetracycline appears to be a useful alternative to systemic steroids in the treatment of bullous pemphigoid. It is less toxic and safer than dapsone and prednisone. Nicotinamide is well tolerated and often can be used by those who cannot tolerate topical retinoids or fruit acids. Anticancer effects However, research doesn’t support the notion that niacinamide can prevent the onset of type 1 diabetes, although it may help delay its progression by preserving beta cell function ( 24, 25, 26, 27). Raines NH, Ganatra S, Nissaisorakarn P, et al. Niacinamide May Be Associated with Improved Outcomes in COVID-19-Related Acute Kidney Injury: An Observational Study. Kidney360 2020;2(1):33-41. View abstract.Since it’s water-soluble, your body doesn’t store this vitamin, which is why you need to eat nicotinic acid or niacinamide daily.

Nicotinamide Prevents Common Skin Cancers in High-Risk Oral Nicotinamide Prevents Common Skin Cancers in High-Risk

Owing to its role in keeping your cells healthy, oral supplements of niacinamide have been shown to enhance DNA repair in UV damaged skin in humans ( 9, 10). Vitamin B3 plays a vital role in converting the food you eat into usable energy and helps your body’s cells carry out important chemical reactions ( 1). El-Khalawany M, Nouh AH, Kadah AS, Elsheikh M, Said M. Evaluation of safety and efficacy of topical 4% nicotinamide in treatment of psoriasis; among a representative sample of Egyptians (an analytical observational study). Dermatol Ther 2022;35(9):e15734. View abstract. Mainville L, Smilga AS, Fortin PR. Effect of Nicotinamide in Skin Cancer and Actinic Keratoses Chemoprophylaxis, and Adverse Effects Related to Nicotinamide: A Systematic Review and Meta-Analysis. J Cutan Med Surg 2022;26(3):297-308. View abstract. Fabbrocini G, Cantelli M, Monfrecola G. Topical nicotinamide for seborrheic dermatitis: an open randomized study. J Dermatolog Treat. 2014 Jun;25(3):241-5. View abstract.

Soma Y, Kashima M, Imaizumi A, et al. Moisturizing effects of topical nicotinamide on atopic dry skin. Int J Dermatol. 2005;44(3):197-202. View abstract. Kamal M, Abbasy AJ, Muslemani AA, Bener A. Effect of nicotinamide on newly diagnosed type 1 diabetic children. Acta Pharmacol Sin. 2006;27(6):724-7. View abstract.

Nicotinamide | DermNet Nicotinamide | DermNet

Navarrete-Solís J, Castanedo-Cázares JP, Torres-Álvarez B, et al. A double-blind, randomized clinical trial of niacinamide 4% versus hydroquinone 4% in the treatment of melasma. Dermatol Res Pract. 2011;2011:379173. A double-blind, placebo-controlled, split-face, left-right, randomised 12-week study in 50 women evaluated the effects of 5% topical nicotinamide on various signs of skin ageing. The researchers reported topical nicotinamide resulted in significant improvement in fine lines/wrinkles, pigmentation, texture and red blotchiness. The study was sponsored by Proctor and Gamble. Nicotinamide is naturally present in small quantities in yeast, lean meats, fish, nuts and legumes. It is also often added to cereals and other foods. Oral nicotinamide is available as 20–30 mg in multivitamin combinations, and on its own as inexpensive 500-mg tablets. It has also been incorporated in many topical agents including sunscreens and cosmetic agents. How does nicotinamide work? Kalasho BD, Minokadeh A, Zhang-Nunes S, et al. Evaluating the Safety and Efficacy of a Topical Formulation Containing Epidermal Growth Factor, Tranexamic Acid, Vitamin C, Arbutin, Niacinamide and Other Ingredients as Hydroquinone 4% Alternatives to Improve Hyperpigmentation: A Prospective, Randomized, Controlled Split Face Study. J Cosmet Sci. 2020 Sep/Oct;71(5):263-290.

What is nicotinamide?

Kozan A, Guner RY, Akyol M. A retrospective assessment and comparison of the effectiveness of benzoyl peroxide; the combination of topical niacinamide, gallic acid, and lauric acid; and the combination of benzoyl peroxide and erythromycin in acne vulgaris. Dermatol Ther. 2020 Jul;33(4):e13534.