Severe forms of skin reactions such as bullous reactions including Stevens- Johnson syndrome, erythema multiforme and toxic epidermal necrolysis can occur. For arthritic pain: The dosage range is from 0.9 to 2.4 g per day. The usual dose is 400 mg, 3-4 times per day, preferably after food. The dose may be raised to a maximum of 2.4 g daily depending on the severity of symptom at the time of initiating drug therapy or as patients fail to respond. After a satisfactory response has been achieved the patients dose should be reviewed and adjusted as required and tapered gradually. The elderly have an increased frequency of adverse reactions to NSAIDs especially gastrointestinal bleeding and perforation which may be fatal.

Nurofen Cold & Flu Relief 200mg/5mg Tablets, Nurofen Day & Night Cold & Flu 200mg/5mg Tablets, Contains ibuprofen & phenylephrine hydrochloride, For cold & flu relief. Systemic lupus erythematosus and mixed connective tissue disease - increased risk of aseptic meningitis (See section 4.8). You should start to notice the pain relieving effects of Nurofen Meltlets within 30 to 60 minutes of taking the tablets. Other NSAIDs including cyclooxygenase-2 selective inhibitors: Avoid concomitant use of two or more NSAIDs as this may increase the risk of adverse effects (see section 4.4)

Food Interaction

years: 2 tea spoonful (10 ml) 3-4 times daily. Nurofen Meltletsis not recommended for children under 1 year. Clinical studies suggest that use of ibuprofen, particularly at high dose (2400 mg/day) may be associated with a small increased risk of arterial thrombotic events (for example myocardial infarction or stroke). Overall, epidemiological studies do not suggest that low dose ibuprofen (e.g. ≤1200 mg/day) is associated with an increased risk of arterial thrombotic events. Patients with a history of GI toxicity, particularly the elderly, should report any unusual abdominal symptoms (especially GI bleeding) particularly in the initial stages of treatment. Care is advised in the administration of paracetamol to patients with severe renal or severe hepatic impairment . The hazards of overdose are greater in those with non-cirrhotic alcoholic liver disease. Chronic alcohol users should consult a doctor before use. Talk to a doctor at once if your child takes too much of this medicine, even if they seem well. This is because too much paracetamol can cause delayed, serious liver damage.

a)- Is on long term treatment with carbamezepine, Phenobarbital, phenytoin, primidone, rifampicin, St John's Wort or other drugs that induce liver enzymes.The antipyretic effect is reported to be linked to the effect on the prostanoid synthesis due to the fact that the prostanoids are the main signaling mediator of pyresis in the hypothalamic-preoptic region. cardiopulmonary toxicity (premature constriction/closure of the ductus arteriosus and pulmonary hypertension); Do not give to children under 12 years. In children and adolescents between 12 and 18 years: If in children and adolescents this medicinal product is required for more than 3 days, or if symptoms worsen a doctor should be consulted. But people don’t realize that using highly inflammatory substances causes more harm to their bodies than benefit.

Please be aware that Nurofen Meltlets contains ibuprofen. You should not take any other medicines that also contain these ingredients (or other anti-inflammatories, such as Aspirin or Naproxen) at the same time as Nurofen Meltlets. In limited studies, ibuprofen appears in the breast milk in very low concentration and is unlikely to affect the breast-fed infant adversely. Chronic hepatic necrosis has been reported in a patient who took daily therapeutic doses of paracetamol for about a year and liver damage has been reported after daily ingestion of excessive amounts for shorter periods. A review of a group of patients with chronic active hepatitis failed to reveal differences in the abnormalities of liver function in those who were long-term users of paracetamol nor was the control of their disease improved after paracetamol withdrawal.Clinical studies suggest that use of ibuprofen, particularly at high doses (2400 mg/day) may be associated with a small increased risk of arterial thrombotic events (for example myocardial infarction or stroke). Overall, epidemiological studies do not suggest that low dose ibuprofen (e.g. ≤1200 mg/day) is associated with an increased risk of arterial thrombotic events. You should speak to a doctor or pharmacist for advice before using Nurofen Meltlets if you are recently taken or are currently taking any prescribed or non-prescribed medication. A full list of medications that may interact with Nurofen Meltlets can be found in the Patient Information Leaflet. In children ingestion of more than 400 mg/kg may cause symptoms. In adults the dose response effect is less clear cut. The half-life in overdose is 1.5-3 hours. If this product is required for children and adolescents for more than 2 days or if symptoms worsen, seek advice from your GP Low level transaminase elevations may occur in some patients taking therapeutic doses of paracetamol; these elevations are not accompanied with liver failure and usually resolve with continued therapy or discontinuation of paracetamol.

Nurofen Plus, Contains ibuprofen and codeine, For the short-term treatment of acute, moderate pain which is not considered to be relieved by other analgesics such as paracetamol, ibuprofen or aspirin alone. For 3 days use only. May cause addiction. Caution should be taken when paracetamol is used concomitantly with flucloxacillin as concurrent intake has been associated with high anion gap metabolic acidosis, especially in patients with risks factors (see section 4.4). Zidovudine: Increased risk of haematological toxicity when NSAIDs are given with zidovudine. There is evidence of an increased risk haemarthroses and haematoma in HIV(+) haemophiliacs receiving concurrent treatment with zidovudine and ibuprofen.

Elimination Route

Chronic hepatic necrosis has been reported in a patient who took daily therapeutic doses of paracetamol for about a year. You should therefore always seek the advice of your doctor or pharmacist before you use this medicine with other medicines. Other warnings • this medicine belongs to a group of medicines which may impair fertility in women. This is reversible on stopping the medicine. It is unlikely that this medicine, used occasionally will affect your chances of becoming pregnant.