In a 35-day study in children aged 5 to 12, no tolerance to the antihistaminic effect (suppression of wheal and flare) of cetirizine was found. When a treatment with cetirizine is stopped after repeated administration, the skin recovers its normal reactivity to histamine within 3 days.

Hepatically impaired patients: Patients with chronic liver diseases (hepatocellular, cholestatic, and biliary cirrhosis) given 10 or 20 mg of cetirizine as a single dose had a 50 % increase in half-life along with a 40 % decrease in clearance compared to healthy subjects.Express Delivery (1-2 Working Days) ( Excluding Saturday Delivery) (Please be aware when you select Courier Next Day for northern parts of Scotland, DPD may take 2 days to deliver) It's fine to take cetirizine in combination with other types of medicine for hay fever, for example nasal sprays or eye drops. Frequencies are defined as follows: Very common (≥1/10); common (≥1/100 to <1/10); uncommon (≥1/1,000 to <1/100); rare (≥1/10,000 to <1/1,000); very rare (<1/10,000), not known (cannot be estimated from the available data) Always read the label. Ask your pharmacist for advice. At the recommended dosage, BENADRYL ® products do not cause drowsiness in the majority of sufferers. Cetirizine, a human metabolite of hydroxyzine, is a potent and selective antagonist of peripheral H 1-receptors. In vitro receptor binding studies have shown no measurable affinity for other than H 1-receptors.

Rare: hepatic function abnormal (increased transaminases, alkaline phosphatase, γ-GT and bilirubin)

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You can take a dose of this medicine to reduce allergy symptoms once they have started. Or you can take it in anticipation of getting allergy symptoms, for instance you can take a dose before leaving the house if you know there will be a high pollen count, or if you're visiting friends with a pet you're allergic to. You can also take it regularly every day to prevent symptoms, such as during the pollen season. Do not give this medication to a child younger than 2 years old. Always ask a doctor before giving a cough or cold medicine to a child. Death can occur from the misuse of cough and cold medicines in very young children. Undesirable effects are described according to MedDRA System Organ Class and by estimated frequency based on the post-marketing experience. Women who are pregnant. If you suffer with allergies during pregnancy you should get advice from your doctor on how to treat your symptoms, because locally acting medicines like nasal sprays are usually preferred. Cetirizine can be used if necessary, but only if the benefits outweigh any risks and only if it's prescribed by your doctor. Studies in healthy volunteers show that cetirizine, at doses of 5 and 10 mg strongly inhibits the wheal and flare reactions induced by very high concentrations of histamine into the skin, but the correlation with efficacy is not established.