The team lands in the Yucatán Peninsula, where they witness the launch of a mysterious Federation missile. As a result of the oil crisis, an authoritative military dictatorship known as the Federation of the Americas is established in South America, with its founding members being Venezuela, Chile, Argentina, and Brazil. The team then breaks into the factory and discovers that the Federation reverse-engineered ODIN into their own orbital bombardment system named LOKI. The first map, "Point of Contact", is included within the base game, and serves as an introduction to the game mode.

The 103 third parties who use cookies on this service do so for their purposes of displaying and measuring personalized ads, generating audience insights, and developing and improving products. Constructing a counterattack, the Ghosts make significant gains against the Federation by destroying their Atlas oil platform in Antarctica and sinking a destroyer guarding a Federation factory in the port of Rio de Janeiro.

The Extinction story takes place in an alternate reality following the events of the first mission of the Ghosts campaign, where the ODIN strike unearths ancient creatures known as Cryptids upon mankind. Using her as a beacon, Archer guided the destroyer toward the remaining Cryptid Arks around the world. The third map pack, Invasion, was released on the Xbox 360 and Xbox One on June 3, 2014, and on PlayStation 3, PlayStation 4, and Windows, on July 3, 2014. The live-action teaser trailer for Ghosts, titled "Masked Warriors", features glimpses of people wearing historical battle masks, among them one of a group of soldiers putting on the skull mask shown on the box art.

CIF Team One was sent in once again to rescue Archer, as well as eliminate Cross, per the deal between Archer and CIF Team One's handler, General "Godfather" Castle. If a player collects a fallen teammate's dog tag, no points are award to the enemy team; first team to 100 points wins the game. Due to a "configuration issue" however, the PlayStation 4 version still required a release day patch to reach 1080p.

After destroying the factory, the Ghosts regroup at a safe house in Las Vegas, but are captured by Rorke and Federation armed forces and paramilitary forces, who executes Elias. They seize control of LOKI and decimate the Federation armed forces by turning their weapons on them. This features a squad that the player can build and the player can face other squads around the world. Infected: Similar to the mode in Modern Warfare 3, one player is randomly infected at the beginning and can infect other players until either all survivors are infected, or time runs out.

In the midst of the operation, Cross regained contact with the survivors, reasoning CIF Team One must sacrifice themselves to activate the Medusa, a psionic weapon capable of eradicating all Cryptids within a three-mile radius, and give mankind a chance to overcome extinction. It also includes two new multiplayer weapons: the Maverick assault rifle, and the Maverick A-2 sniper rifle; as well as "Nightfall", the first of the four Extinction episodic contents.The second map pack, Devastation, was released on the Xbox 360 and Xbox One on April 3, 2014, and on PlayStation 3, PlayStation 4, and Windows, on May 8, 2014.