Prebiotics & Glutamine: Mannan oligosaccharides are yeast extracts which bind themselves to harmful bacteria and help prevent them from attaching to the gut lining. They also aid digestion and enhance the immune system. Kaysen GA, Pond SM, Roper MH, Menke DJ, Marrama MA. Combined hepatic and renal injury in alcoholics during therapeutic use of acetaminophen. Arch Intern Med. 1985;145:2019-23.

Glutamine is a naturally occurring amino acid. It is the most important nutrient for the cells lining the intestine, and provides these cells with vital energy. This reduces damage to the gut lining, thus speeding recovery. Please note that parcels weighing over 2kg may be sent via courier due to Royal Mail weight restrictions.Glutamine – is the most important nutrient for rapidly dividing gut cells such as mucosal immune cells and epithelial enterocytes. It helps in maintaining the integrity of the mucosa and reduce bacterial translocation to the mesenteric lymph nodes. Glutamine stimulates both B and T lymphocyte function and increases immunoglobulin synthesis. Wong V, Daly M, Boon A, Heatley V. Paracetamol and acute biliary pain with cholestasis. Lancet. 1993;342:869. Seeff LB, Cuccherini BA, Zimmerman HJ, Adler E, Benjamin SB. Acetaminophen hepatotoxicity in alcoholics. Ann Intern Med. 1986;104:399-404. Overdosages are unlikely to happen with a graduated syringe. Side effects and contraindications have not been mentioned/reported by the manufacturer. There are a number of measures you can take that can support your dog’s digestive health like a bland, easily digestible, balanced diet; High energy diets and Ensuring your pet stays hydrated. Singer AJ, Carracio TR, Mofenson HC. The temporal profile of increased transaminase levels in patients with acetaminophen-induced liver dysfunction. Ann Emerg Med. 1995;26:49-53.

Mannan Oligosaccharide (MOS) – has prebiotic effect in maintaining normal gut flora in dogs, by increasing the populations of non-pathogenic lactobacilli and is effective in the control of pathogenic coli. MOS attracts pathogens to attach to mannose sugars on its surface rather than to the villi lining the intestine. MOS has been demonstrated to enhance local immunity in the gut by stimulating the proliferation of B lymphocytes and IgA production. Probiotic Promax uses an Eu-registered strain of probiotic called Enterococcus faecium E1707 which multiplies rapidly in the intestine, increasing gut acidity and inhibiting the growth of harmful bacteria. Common (1% to 10%): Dyspnea, abnormal breath sounds, pulmonary edema, hypoxia, pleural effusion, stridor, wheezing, coughing [ Ref] Cardiovascular Filipe PL, Freitas JP, Decastro JC, Silva R. Drug eruption induced by acetaminophen in infectious mononucleosis. Int J Dermatol. 1995;34:220-1. Along with its needed effects, acetaminophen (the active ingredient contained in Promax) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.They also aid digestion and enhance the immune system. Glutamine is a naturally occurring amino acid. It is the most important nutrient for the cells lining the intestine, and provides these cells with vital energy. This reduces damage to the gut lining, thus speeding recovery. Kawada A, Hiruma M, Noguchi H, Ishibashi A. Fixed drug eruption induced by acetaminophen in a 12-year-old girl. Int J Dermatol. 1996;35:148-9. Kumar S, Rex DK. Failure of physicians to recognize acetaminophen hepatotoxicity in chronic alcoholics. Arch Intern Med. 1991;151:1189-91. Bonkovsky HL, Kane RE, Jones DP, Galinsky RE, Banner B. Acute hepatic and renal toxicity from low doses of acetaminophen in the absence of alcohol abuse or malnutrition - evidence for increased susceptibility to drug toxicity due to cardiopulmonary and renal insufficiency. Hepatology. 1994;19:1141-8. an advanced syringe design exclusively developed by VetPlus and ensures correct feeding and easy administration

Applies to acetaminophen: capsule, capsule liquid filled, elixir, liquid, powder, solution, suppository, suspension, tablet, tablet chewable, tablet disintegrating, tablet extended release. Other dosage forms: Settipane RA, Stevenson DD. Cross sensitivity with acetaminophen in aspirin-sensitive subjects with asthma. J Allergy Clin Immunol. 1989;84:26-33.Kurtovic J, Riordan SM. Paracetamol-induced hepatotoxicity at recommended dosage. J Intern Med. 2003;253:240-3.

probiotic called Enterococcus faecium E1707 which multiplies rapidly in the intestine, increasing gut acidity and inhibiting the growth of harmful bacteria. Enterococcus faecium also helps to restore the natural balance of gut bacteria.

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Keaton MR. Acute renal failure in an alcoholic during therapeutic acetaminophen ingestion. South Med J. 1988;81:1163-6. Gursoy M, Haznedaroglu IC, Celik I, Sayinalp N, Ozcebe OI, Dundar SV. Agranulocytosis, plasmacytosis, and thrombocytosis followed by a leukemoid reaction due to acute acetaminophen toxicity. Ann Pharmacother. 1996;30:762-5. Koulouris Z, Tierney MG, Jones G. Metabolic acidosis and coma following a severe acetaminophen overdose. Ann Pharmacother. 1999;33:1191-4. Further information Inflammation of the large intestine (colitis) is the most common form of digestive upset, and it results in the dog needing to frequently pass small amounts of diarrhoea that often include mucus and sometimes traces of bright red blood. Kondo K, Inoue Y, Hamada H, Yokoyama A, Kohno N, Hiwada K. Acetaminophen-induced eosinophilic pneumonia. Chest. 1993;104:291-2.