Felbab-Brown, Vanda (2009). "The Political Economy of Illegal Domains in India and China". The International Lawyer. 43 (4): 1411–1428. ISSN 0020-7810. JSTOR 40708079. But although opium poppy provided a source of funding for Mao's opponents, and although ideologically it was an anathema to him, Mao too did not attempt to interfere with the poppy economy during his insurgency years. Large segments of the population were dependent upon the poppy economy, and Mao was in turn in need of the rural population's support, or at least its tolerance of his anti-Chiang Kai-shek insurgency. Over time, not only did Mao tolerate poppy cultivation, he actually came to tax it as well. Use of opium as a cure-all was reflected in the formulation of mithridatium described in the 1728 Chambers Cyclopedia, which included true opium in the mixture. Nei zheng bu (1956). Chinese communists' world-wide narcotic war. Taipei，Taiwan: Ministry of Interior, Republic of China. OCLC 55592114. In 2021, the International Agency for Research on Cancer concluded that opium is a Group 1 (sufficient evidence) human carcinogen, causing cancers of the larynx, lung, and urinary bladder. [157] Slang terms [ edit ]

Presley CC, Lindsley CW. DARK Classics in Chemical Neuroscience: opium, a historical perspective. ACS Chemical Neuroscience. 2018;9(10):2503-18. Heroin comes from the gum of opium poppies ( Papaver somniferum). These flowers aren't difficult to grow, Wankel said. They thrive in temperate climates and are probably native to the Mediterranean, but they can be grown in subtropical and tropical regions as well. Heroin which is derived from opium is most often injected, however, it may also be vaporized (or smoked), sniffed (also known as snorting), used as a rectal suppository, or orally ingested by mouth. Wong, J. Y. (7 November 2002). Deadly Dreams: Opium and the Arrow War (1856-1860) in China. Cambridge University Press. ISBN 978-0-521-52619-7.Suzanne Carr (1995). "MS thesis". Archived from the original on November 8, 2009 . Retrieved May 16, 2007. (citing Andrew Sherratt) Opium is the first substance of the diverse group of the opiates. It has been known for a long time, and the first evidence of a poppy culture dates from 5 thousand years by the Sumerians. During the years, opium was used as a sedative and hypnotic, but it was determined to be addictive. 1 Giving up opium after using it for a long time is challenging because the body must get used to functioning without it. Withdrawing from opium is similar to withdrawing from other opioid drugs. The use of diethyl ether and chloroform for general anesthesia began in 1846–1847, and rapidly displaced the use of opiates and tropane alkaloids from Solanaceae due to their relative safety. [103]

Opium smoking began as a privilege of the elite and remained a great luxury into the early 19th century. However, by 1861, Wang Tao wrote that opium was used even by rich peasants, and even a small village without a rice store would have a shop where opium was sold. [47] Heroin is classified as a Schedule I drug under the Controlled Substances Act of 1970 and as such has no acceptable medical use in the United States. The standard medical use of opium persisted well into the 19th century. US president William Henry Harrison was treated with opium in 1841, and in the American Civil War, the Union Army used 175,000lb (80,000kg) of opium tincture and powder and about 500,000 opium pills. [1] During this time of popularity, users called opium "God's Own Medicine". [36] The treaties with the British soon led to similar arrangements with the United States and France. These later became known as the Unequal Treaties, while the Opium Wars, according to Chinese historians, represented the start of China's " Century of humiliation". Despite drastic penalties and continued prohibition of opium until 1860, opium smuggling rose steadily from 200 chests per year under the Yongzheng Emperor to 1,000 under the Qianlong Emperor, 4,000 under the Jiaqing Emperor, and 30,000 under the Daoguang Emperor. [61] The illegal sale of opium became one of the world's most valuable single commodity trades and has been called "the most long continued and systematic international crime of modern times". [62] Opium smuggling provided 15 to 20 percent of the British Empire's revenue and simultaneously caused scarcity of silver in China. [63]Most illicit heroin is sold as a white or brownish powder and may be "cut" with other substances such as sugar, starch, powdered milk, or quinine. It can also be cut with strychnine or other poisons. Ms Louise Foxcroft (28 June 2013). The Making of Addiction: The 'Use and Abuse' of Opium in Nineteenth-Century Britain. Ashgate Publishing. pp.66–. ISBN 978-1-4094-7984-0. a b Kramer John C (1979). "Opium Rampant: Medical Use, Misuse and Abuse in Britain and the West in the 17th and 18th Centuries". British Journal of Addiction. 74 (4): 377–389. doi: 10.1111/j.1360-0443.1979.tb01367.x. PMID 396938. It is mainly used to treat masculinity, strengthen sperm, and regain vigour. It enhances the art of alchemists, sex and court ladies. Frequent use helps to cure the chronic diarrhea that causes the loss of energy ... Its price equals that of gold. [11] Michael-Titus A., Revest P. and Shortland P. (2010). The nervous system (2nd ed.). Churchill Livingstone.

Heroin, the first semi-synthetic opioid, was first synthesized in 1874, but was not pursued until its rediscovery in 1897 by Felix Hoffmann at the Bayer pharmaceutical company in Elberfeld, Germany. From 1898 to 1910 heroin was marketed as a non-addictive morphine substitute and cough medicine for children. Because the lethal dose of heroin was viewed as a hundred times greater than its effective dose, heroin was advertised as a safer alternative to other opioids. [104] By 1902, sales made up 5 percent of the company's profits, and "heroinism" had attracted media attention. [105] Oxycodone, a thebaine derivative similar to codeine, was introduced by Bayer in 1916 and promoted as a less-addictive analgesic. Preparations of the drug such as oxycodone with paracetamol and extended release oxycodone remain popular to this day. [ citation needed] In Eastern culture, opium is more commonly used in the form of paregoric to treat diarrhea. This is a weaker solution than laudanum, an alcoholic tincture which was prevalently used as a pain medication and sleeping aid. Tincture of opium has been prescribed for, among other things, severe diarrhea. [151] Taken thirty minutes prior to meals, it significantly slows intestinal motility, giving the intestines greater time to absorb fluid in the stool. Hamarneh Sami (1972). "Pharmacy in medieval Islam and the history of drug addiction". Medical History. 16 (3): 226–237. doi: 10.1017/s0025727300017725. PMC 1034978. PMID 4595520. Lowes, Peter D. (1966). The Genesis of International Narcotics Control. Librairie Droz. ISBN 978-2-600-04030-3. Opium prohibition in China began in 1729, yet was followed by nearly two centuries of increasing opium use. A massive destruction of opium by an emissary of the Chinese Daoguang Emperor in an attempt to stop opium smuggling by the British led to the First Opium War (1839–1842), in which Britain defeated China. After 1860, opium use continued to increase with widespread domestic production in China. By 1905, an estimated 25 percent of the male population were regular consumers of the drug. Recreational use of opium elsewhere in the world remained rare into late in the 19th century, as indicated by ambivalent reports of opium usage. [44] In 1906, 41,000 tons were produced, but because 39,000 tons of that year's opium were consumed in China, overall usage in the rest of the world was much lower. [48] These figures from 1906 have been criticized as overestimates. [49] A Chinese opium house; photographed in 1902

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Opium contains 50 different alkaloid opiates. The most common metabolism of opiates is to be ultimately converted to morphine which is further converted to morphine-3,6-diglucuronide. 16 Opioids are metabolized vastly by the enzyme CYP 2D6 and any mutation in this kind of enzyme or coadministration with drugs that interfere with this enzyme may generate a change in the metabolism speed. 18 For years, because of this metabolism pathway, it was very hard to differentiate between illicit heroin users and involuntary exposure to poppy seeds. The original tests for this differentiations were based in the presence of morphine in urine without evidence of 6-monoacetylmorphine. Now it is known the presence of a glucuronide metabolite only in the consumption of heroin called ATM4G and this allows a clear differentiation of the consumption of illegal heroin and poppy seed ingestion. 6 a b Commissioner Jesse B. Cook (June 1931). "San Francisco's Old Chinatown". San Francisco Police and Peace Officers' Journal . Retrieved September 22, 2007.