Groundbreaking for its day, it has now become the gold standard for Vitamin C serums and inspired a long string of dupes (and lawsuits). Now they’re bringing another innovation, 15% L-Ascorbic Acid (Vitamin C) + Ferulic Acid + Phloretin. Will it be as successful as its predecessor? Only time will tell. Key Ingredients In Skinceuticals Phloretin CF: What Makes It Work?

If you’re serious about antiaging, you need this baby in your skincare routine. But be careful! L-Ascorbic Acid has a couple of side effects you should be aware of: The experts from SkinCeuticals are here to help you decide which bestselling antioxidant serum is right for you and what products you should be pairing with it. Once absorbed, this serum can’t be washed or rubbed off. It remains effective for a minimum of 72 hours, making it an excellent addition to sunscreen. The serum comes in a dark bottle with a dropper applicator. The dark colour keeps the actives inside (especially sun sensitive Vitamin C) safe from UV rays that would degrade it and compromise its effectiveness.Hi, I'm Gio! I’m a tell-it-like-it-is skin coach and author on a mission to help you achieve your best skin day ever - every day. Three-Time Allure Best of Beauty Award Winner: Best Breakthrough, Best Serum, Best Antioxidant Anti-Ager. Elle, Shape, Vogue, InStyle, New Beauty, People. The next key ingredient in SkinCeuticals Phloretin CF is phloretin, a flavonoid derived from apples and the root bark of fruit trees including apple, pear, and grapefruit. Phloretin is an antioxidant that neutralizes damaging free radicals. It also helps increase cell turnover, improves the appearance of discoloration, and helps other beneficial ingredients penetrate deeper into the skin. Vitamin C is a must for anti-aging, but no particular serum is an absolute must – especially at this price point. But if your skin can’t tolerate high doses of Vitamin C (and your wallet can take the hit), this is an effective alternative to consider. Dupes & Alternatives

This antioxidant combination isn’t as well-researched as Vitamin C + Vitamin E + ferulic acid, so it may be less effective.Delays the deposition of sugar deposits in your skin (sugar hardens collagen, resulting in wrinkles).

Inhibits TLR2/1 heterodimerization; reduces TNF-α; and IL-8; exhibits micromolar binding affinity to TLR2. Did you know that SkinCeuticals Founding Scientist Sheldon Pinnell, M.D. filed the first vitamin C patent in 1992? This discovery paved the way for an entirely new skin care category: topical vitamin C. Thus, it makes sense that vitamin C is included in many SkinCeuticals skincare products, with SkinCeuticals Phloretin CF being no exception. This antioxidant serum features a patented synergistic combination of 10% pure vitamin C (L-ascorbic acid), 2% phloretin, and 0.5% ferulic acid. We’ll discuss each of these ingredients in detail below so you’ll know exactly how they affect your skin. aqua / water / eau, dipropylene glycol, alcohol denat., ascorbic acid, butylene glycol, triethyl citrate, phloretin, ferulic acid About GioHi, I'm Gio. I'm a no-nonsense, tell-it-like-it-is skin coach and writer on a mission to help you achieve your best skin day ever - every day. I bust skincare myths and debunk marketing jargon to help you figure out what's worth the splurge and what's best left on the shelf - using science, not hype. I also offer skincare consultations to help you create the best skincare routine for your unique needs. According to a 2008 study, it gives similar results to the classic combo of Vitamin C + Vitamin E + Ferulic Acid: One common link to the release of the above-mentioned proinflammatory mediators from activated macrophages is the nuclear transcription factor κ-B (NF-κB) which regulates the expression of several genes (e.g., chemokines, cytokines, and adhesion molecules) involved in inflammation. For details of NF-κB signalling, readers can refer to the numerous review articles in the field (e.g., [ 40, 41]). The NF-κB represents a family of protein transcription factors such as NF-κB1 (also named p50), NF-κB2 (also named p52), RelA (also named p65), RelB, and c-Rel. The expression of target genes happens when these transcription factors translocate from the cytoplasm to the nucleus and bind (through their transcriptional transactivation domain at their C-terminus) to the κB enhancer region of the DNA. Since the NF-κB proteins are sequestered in the cytoplasm by binding to inhibitory proteins, including inhibitors of κB (IκB) family members (most important is IκBα, others include IκBβ, IκBε, and their precursors), releasing the NF-κB from the complex is a key cell signalling step in inflammatory genes activation. Many agents that activate the inflammatory pathway such as LPS stimulate the degradation of IκBα via the multi-subunit IκB kinase (IKK)-induced phosphorylation. This further triggers ubiquitin-dependent IκBα degradation in the proteasome, thereby allowing the nuclear translocation of NF-κB. The IKK itself is a complex of two kinases (IKKα and IKKβ) and other proteins and constitutes the classic example of the canonical NF-κB pathway of activation which is common to various immunostimulant-based macrophage activation: i.e., the IκBα degradation-execute the canonical activation pathway of NF-κB. A variety of inflammatory stimuli activate the canonical pathway in macrophages, and these include proinflammatory cytokines, pattern-associated molecular patterns (PAMPs), or damage-associated molecular patterns (DAMPs) binding to cognate receptors. The LPS is recognised in macrophages by Toll-like receptors (e.g., TLR4) and its stimulatory effect is orchestrated through the canonical pathway. Other pathways or the noncanonical NF-κB pathway of activation are, however, also known. Activation of macrophages to a phenotypically M1 state leads to the induction of inflammatory mediators (e.g., IL-1, IL-6, IL-12, TNF-α, and chemokines) which promotes the process of inflammation while the M2 phenotype leads to the production of anti-inflammatory cytokines (e.g., IL-10 and IL-13) which promote resolution of inflammation (e.g., during the wound healing stage) [ 42]. Most of the anti-inflammatory mechanisms of phloretin discussed in the following sections are associated with modulation of the above-mentioned signalling pathway of NF-κB including macrophage polarisation. A mineral tinted fluid, this daily sunscreen is suitable for all skin types and instantly helps improve the appearance of uneven skin tone while protecting the skin from further discoloration and damage. Featuring micro-fine zinc oxide (Z-Cote®) and titanium dioxide to provide broad spectrum protection against UVA/UVB rays, this ultra-sheer, non-irritating formula is infused with artemia salina to enhance the skin’s natural defenses against UV- and heat-induced stress, plus translucent color spheres that help even out skin tone and boost skin’s radiance upon application. With a paraben- and fragrance-free, non-comedogenic formula that’s ideal for all skin types (including sensitive), this lightweight, water-resistant fluid provides a touch of coverage and leaves skin with a soft, radiant finish as well as no white cast. For evening use: Retinol 0.3, 0.5 or 1.0

Once absorbed this antioxidant remains effective for a minimum of 72 hours, enhancing the benefits of your normal sunscreen. This broad-spectrum treatment provides advanced environmental protection to defend skin against the reactive molecules (including free radicals) that are known to cause cellular damage. In addition to its superior antioxidant capabilities, it has been proven to correct existing damage from the inside out. Alcohol Denat is one of the most misunderstood ingredients in skincare. Word on the street is that it’s terribly drying and irritating. NOTE: The colours indicate the effectiveness of an ingredient. It is ILLEGAL to put toxic and harmful ingredients in skincare products. Phloretin CF provides powerful antioxidant protection, suitable for Normal, Oily and Combination skin types to improve discolouration, fine lines and wrinkles with its blend of phloretin, vitamin C and ferulic acid.The most common skin concern during pregnancy is hyperpigmenation. According to the British Association of Dermatologists, it can affect up to 50% of women during their pregnancy, because hormones are slightly out of kilter and your body starts to produce more oestrogen. Combined with an increase in photosensitivity, this presents itself as large patches of discolouration on the face. The increase in oestrogen is also why your areola (the round area around your nipples) darkens. What you can see straight away is the brightening effect. Phloretin CF makes my skin glow! It also makes it a little softer and smoother. How Does Skinceuticals Phloretin CF Compare To Skinceuticals CE Ferulic? In the various sections of this review ( Section 2, Section 3, Section 4, Section 5, Section 6, Section 7, Section 8, Section 9, Section 10 and Section 11), the anti-inflammatory potential of phloretin that has been established through studies both in vitro and in vivo are outlined. Indeed, phloretin does also possess various other pharmacological effects including anticancer properties. Readers should bear in mind that carcinogenesis and the process of cancer metastasis including angiogenesis share some aspects of inflammation biology. Hence, the reported anti-inflammatory mechanism of phloretin could also be relevant to its anticancer properties. The focus of this section is however to summarise the anti-inflammatory mechanism of phloretin that accounts for its diverse other effects in vitro and in vivo.