Gaudiya Vaishnavas generally also abstain from caffeine, because they believe it clouds the mind and overstimulates the senses. [284] To be initiated under a guru, one must have had no caffeine, alcohol, nicotine or other drugs, for at least a year. [285] Drinking between 3–5 cups of coffee per day or more than 3 cups of tea per day may also reduce the risk of brain diseases such as Alzheimer’s and Parkinson’s by 28–60% ( 10, 11, 12, 13).

Skin protection. Consuming 4 or more cups of caffeinated coffee per day may lower the risk of skin cancer by 20% ( 46, 47). While caffeine does not directly bind to any dopamine receptors, it influences the binding activity of dopamine at its receptors in the striatum by binding to adenosine receptors that have formed GPCR heteromers with dopamine receptors, specifically the A 1– D 1 receptor heterodimer (this is a receptor complex with 1 adenosine A 1 receptor and 1 dopamine D 1 receptor) and the A 2A– D 2 receptor heterotetramer (this is a receptor complex with 2 adenosine A 2A receptors and 2 dopamine D 2 receptors). [169] [170] [171] [172] The A 2A–D 2 receptor heterotetramer has been identified as a primary pharmacological target of caffeine, primarily because it mediates some of its psychostimulant effects and its pharmacodynamic interactions with dopaminergic psychostimulants. [170] [171] [172] If you want to reduce or stop consuming caffeine, it’s a good idea to do this gradually. For example, drink one less caffeinated drink each day.USDA Food Data Central. U.S. Department of Agriculture, Agricultural Research Service. https://fdc.nal.usda.gov/index.html. Accessed April 18, 2022. Caffeine can delay or prevent sleep and improves task performance during sleep deprivation. [54] Shift workers who use caffeine make fewer mistakes that could result from drowsiness. [55] You can find out more about caffeine through the Alcohol and Drug Foundation— call their Drug Info and Advice Line on 1300 85 85 84.

a b "Caffeine". ChemSpider. Royal Society of Chemistry. Archived from the original on 14 May 2019 . Retrieved 16 October 2014. Experimental Melting Point: Faudone G, Arifi S, Merk D (June 2021). "The Medicinal Chemistry of Caffeine". Journal of Medicinal Chemistry. 64 (11): 7156–7178. doi: 10.1021/acs.jmedchem.1c00261. PMID 34019396. S2CID 235094871. Interestingly, consuming decaffeinated coffee was also linked to a 21% lower risk of diabetes. This indicates that other beneficial compounds in coffee can also protect against type 2 diabetes ( 36). SummaryPure anhydrous caffeine is a bitter-tasting, white, odorless powder with a melting point of 235–238°C. [10] [11] Caffeine is moderately soluble in water at room temperature (2g/100 mL), but very soluble in boiling water (66g/100 mL). [193] It is also moderately soluble in ethanol (1.5g/100 mL). [193] It is weakly basic (pK a of conjugate acid = ~0.6) requiring strong acid to protonate it. [194] Caffeine does not contain any stereogenic centers [195] and hence is classified as an achiral molecule. [196] An English neuroscientist on the faculty at University of California, Berkeley, Walker, author of Why We Sleep, is single-minded in his mission: to alert the world to an invisible public-health crisis, which is that we are not getting nearly enough sleep, the sleep we are getting is of poor quality, and a principal culprit in this crime against body and mind is caffeine. Caffeine itself might not be bad for you, but the sleep it’s stealing from you may have a price. According to Walker, research suggests that insufficient sleep may be a key factor in the development of Alzheimer’s disease, arteriosclerosis, stroke, heart failure, depression, anxiety, suicide and obesity. “The shorter you sleep,” he bluntly concludes, “the shorter your lifespan.” a b c Wright GA, Baker DD, Palmer MJ, Stabler D, Mustard JA, Power EF, Borland AM, Stevenson PC (March 2013). "Caffeine in floral nectar enhances a pollinator's memory of reward". Science. 339 (6124): 1202–4. Bibcode: 2013Sci...339.1202W. doi: 10.1126/science.1228806. PMC 4521368. PMID 23471406. Caffeine, as do other alkaloids such as cinchonine, quinine or strychnine, precipitates polyphenols and tannins. This property can be used in a quantitation method. [ clarification needed] [213] Natural occurrence Roasted coffee beans