One downside is that while the berberine is thoughtfully sourced for purity, the capsules themselves do contain some additives (microcrystalline cellulose, vegetable magnesium stearate, and silicon dioxide). While none of these additives are unusual, there are other options out there if you are seeking a 100% berberine, additive-free product, such as the PureBulk Berberine HCl Powder. Hu, J. P., Takahashi, N., and Yamada, T. Coptidis rhizoma inhibits growth and proteases of oral bacteria. Oral Dis. 2000;6(5):297-302. View abstract. Wu XK, Wang YY, Liu JP, et al; Reproductive and Developmental Network in Chinese Medicine. Randomized controlled trial of letrozole, berberine, or a combination for infertility in the polycystic ovary syndrome. Fertil Steril. 2016;106:757-765.e1. doi:10.1016/j.fertnstert.2016.05.022 Lu, S. S., Yu, Y. L., Zhu, H. J., Liu, X. D., Liu, L., Liu, Y. W., Wang, P., Xie, L., and Wang, G. J. Berberine promotes glucagon-like peptide-1 (7-36) amide secretion in streptozotocin-induced diabetic rats. J Endocrinol. 2009;200(2):159-165. View abstract.

Berberine for Weight Loss and Insulin Resistance – Cleveland Berberine for Weight Loss and Insulin Resistance – Cleveland

Taking a supplement capsule (or three) every day isn’t for everyone. For those who dislike swallowing pills or who want to avoid additives, PureBulk offers an additive-free Berberine HCl powder that makes it easy to consume berberine in the way that you prefer. Also, you might know that you love berberine and want to buy it in bulk without paying hand over fist. This is where PureBulk excels: you can buy its Berberine HCl powder (made exclusively from Phellodendron amurense bark) in six different sizes, from 25g all the way up to 1kg. Liu, D., Meng, X., Wu, D., Qiu, Z., & Luo, H. (2018). A Natural Isoquinoline Alkaloid With Antitumor Activity: Studies of the Biological Activities of Berberine. Frontiers in Pharmacology, 10. Canker sores. Applying a gel containing berberine can reduce pain, redness, oozing, and the size of canker sores. High-density lipoprotein (HDL) - Zamani M, Zarei M, Nikbaf-Shandiz M, Hosseini S, Shiraseb F, Asbaghi O The effects of berberine supplementation on cardiovascular risk factors in adults: A systematic review and dose-response meta-analysis. Front Nutr. (2022) Ni, Y. X. [Therapeutic effect of berberine on 60 patients with type II diabetes mellitus and experimental research]. Zhong.Xi.Yi.Jie.He.Za Zhi.- Chinese Journal of Modern Developments in Traditional Medicine 1988;8(12):711-3, 707. View abstract.

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The benefits of berberine show potential for anyone diagnosed with Type 2 diabetes or metabolic syndrome — a collection of risk factors that make you more likely to develop serious health issues like diabetes, heart disease and stroke. Lin, S., Tsai, S. C., Lee, C. C., Wang, B. W., Liou, J. Y., and Shyu, K. G. Berberine inhibits HIF-1alpha expression via enhanced proteolysis. Mol Pharmacol 2004;66(3):612-619. View abstract. Babbar, O. P., Chhatwal, V. K., Ray, I. B., and Mehra, M. K. Effect of berberine chloride eye drops on clinically positive trachoma patients. Indian J Med Res. 1982;76 Suppl:83-88. View abstract. Purohit SK, Kochar DK, Lal BB, and et al. Cultivation of Leishmania tropica from untreated and treated cases of oriental sore. Indian Journal of Public Health 1982;26(1):34-37. Iizuka, N., Miyamoto, K., Okita, K., Tangoku, A., Hayashi, H., Yosino, S., Abe, T., Morioka, T., Hazama, S., and Oka, M. Inhibitory effect of Coptidis Rhizoma and berberine on the proliferation of human esophageal cancer cell lines. Cancer Lett 1-1-2000;148(1):19-25. View abstract.

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Hu Q, Peng Z, Li L, Zou X, Xu L, Gong J, Yi P The Efficacy of Berberine-Containing Quadruple Therapy on Helicobacter Pylori Eradication in China: A Systematic Review and Meta-Analysis of Randomized Clinical Trials. Front Pharmacol. (2019) However, sometimes our couriers encounter delays in which case delivery can take up to 4 working days. Rabbani G. Mechanism and treatment of diarrhoea due to Vibrio cholerae and Escherichia coli: roles of drugs and prostaglandins. Danish Medical Bulletin 1996;43:173-185. Zhang, L., Wu, X., Yang, R., Chen, F., Liao, Y., Zhu, Z., Wu, Z., Sun, X., & Wang, L. (2019). Effects of Berberine on the Gastrointestinal Microbiota. Frontiers in Cellular and Infection Microbiology, 10. Berberine has both antimicrobial and anti-inflammatory properties. It may play a role in defending the body against harmful bacterial overgrowth and even promote growth of beneficial organisms in the gut microbiome, which in turn affects a variety of disease processes. 2 While there is still much to uncover in terms of the mechanisms of how exactly berberine works, researchers do know it impacts a host of medical conditions, such as:

Asbaghi, O., Ghanbari, N., Shekari, M., Reiner, Ž., Amirani, E., Hallajzadeh, J., Mirsafaei, L., & Asemi, Z. (2020). The effect of berberine supplementation on obesity parameters, inflammation and liver function enzymes: A systematic review and meta-analysis of randomized controlled trials. Clinical Nutrition ESPEN, 38, 43–49. A review of research shows that keeping gut microbiota balanced can also reduce your risk of colon cancer, inflammatory bowel disease (IBD) and obesity. Berberine activates AMP-activated protein kinase (AMPK), the primary enzyme that monitors and regulates our cellular energy levels. Increasing the amount of AMPK in our bodies gets nutrients where they need to be, effectively controlling our metabolism. This process of AMPK activation is the link to berberine’s benefits for diabetic patients, as well as other conditions like obesity and high cholesterol. AMPK is thought to be a tumor suppressor, too, essentially starving cells while they attempt to form cancerous tumors (though after cancer has developed, AMPK can sometimes promote tumor growth instead). 14 Berberine helps improve how the gut barrier works,” clarifies Dr. Bradley. “We’re finding that it protects the intestinal barrier from all these inflammatory things happening in the body.” What to consider before taking a berberine supplement If you have insulin resistance, the cells don’t have enough glucose, making you feel hungry — there’s improper signaling going on,” explains Dr. Bradley. As you continue eating to satisfy your hunger, your body stores excess blood glucose as fat.

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Wang Y, Yi X, Ghanam K, Zhang S, Zhao T, Zhu X Berberine decreases cholesterol levels in rats through multiple mechanisms, including inhibition of cholesterol absorption. Metabolism. (2014-Sep) Shaffer, J. E. Inotropic and chronotropic activity of berberine on isolated guinea pig atria. J Cardiovasc Pharmacol 1985;7(2):307-315. View abstract. Guo J, Chen H, Zhang X, et al. The effect of berberine on metabolic profiles in type 2 diabetic patients: A systematic review and Meta-analysis of randomized controlled trials. Oxid Med Cell Longev. 2021;2021:2074610. doi: 10.1155/2021/2074610.Dong, H., Wang, N., Zhao, L., & Lu, F. (2011). Berberine in the Treatment of Type 2 Diabetes Mellitus: A Systemic Review and Meta-Analysis. Evidence-based Complementary and Alternative Medicine: ECAM, 2012.

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Research shows that berberine may lower lipid levels. Studies focusing on berberine and heart health also show that the supplement can raise good (HDL) cholesterol while lowering total cholesterol, bad (LDL) cholesterol and blood triglycerides. Furthermore, research suggests berberine may help support the blood-sugar-lowering effects of other diabetes medications when taken alongside them ( 3, 9, 10). Hui, K. K., Yu, J. L., Chan, W. F., and Tse, E. Interaction of berberine with human platelet alpha 2 adrenoceptors. Life Sci. 1991;49(4):315-324. View abstract. Cao, H., Li, C., Lei, L., Wang, X., Liu, S., Liu, Q., Huan, Y., Sun, S., & Shen, Z. (2020). Stachyose Improves the Effects of Berberine on Glucose Metabolism by Regulating Intestinal Microbiota and Short-Chain Fatty Acids in Spontaneous Type 2 Diabetic KKAy Mice. Frontiers in Pharmacology, 11. Hu, X., Zhang, Y., Xue, Y., Zhang, Z., & Wang, J. (2017). Berberine is a potential therapeutic agent for metabolic syndrome via brown adipose tissue activation and metabolism regulation. American Journal of Translational Research, 10(11), 3322-3329.

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Guo, Y., Chen, Y., Tan, Z. R., Klaassen, C. D., and Zhou, H. H. Repeated administration of berberine inhibits cytochromes P450 in humans. Eur J Clin Pharmacol 2012;68(2):213-217. View abstract. Mantena, S. K., Sharma, S. D., and Katiyar, S. K. Berberine, a natural product, induces G1-phase cell cycle arrest and caspase-3-dependent apoptosis in human prostate carcinoma cells. Mol Cancer Ther 2006;5(2):296-308. View abstract. Mirhadi E, Rezaee M, Malaekeh-Nikouei B. Nano strategies for berberine delivery, a natural alkaloid of Berberis. Biomed Pharmacother. 2018;104:465-473. doi:10.1016/j.biopha.2018.05.067 Kuo, C. L., Chi, C. W., and Liu, T. Y. Modulation of apoptosis by berberine through inhibition of cyclooxygenase-2 and Mcl-1 expression in oral cancer cells. In Vivo 2005;19(1):247-252. View abstract. Lan, J., Zhao, Y., Dong, F., Yan, Z., Zheng, W., Fan, J., & Sun, G. (2015). Meta-analysis of the effect and safety of berberine in the treatment of type 2 diabetes mellitus, hyperlipemia and hypertension. Journal of Ethnopharmacology, 161, 69-81.