The most powerful form of nutrient partitioning comes from being active, performing strenuous exercise regularly and having a solid foundation of muscle mass. Staying relatively lean (<20% body fat for men and <30% in women) is likely beneficial as well, although we’re not sure how higher levels of body fat affect nutrient partitioning in healthy, active and trained individuals. Additionally, having a high-quality diet with sufficient antioxidants is likely beneficial. Once these criteria have been met, then you will likely not be able to further alter nutrient partitioning to favour muscle gain. As with any nutritional supplement, the answer is “it depends.” Some people take a glucose disposal agent and find it invaluable to their diabetes management plan. Others don’t notice a difference. Cinnamon Bark Extract - works as a glucose disposal agent (GDA) by slowing down the rate at which glucose actually enters our bodies. This means that you have a two-fold effect of lowering spikes in blood sugar as well as improving glucose utilization within the cell itself. GDA's also play a large role with cheat meals. If you decide to have a cheat meal, your insulin spike is going to be larger than normal as your body is not used to the increased glycogen intake. GDA's will help utilize those carbs to be stored as energy in your muscle rather than fat. Glucose Disposal Agent Ingredients

The PHAT Muscle Project is a family owned business created by John Gorman, Jay Gorman and Leslie Franklin. John and Leslie have spent years in the fitness community working with people of all shapes, sizes, genetics, builds, goals, desires, and dreams to achieve their BEST physique or potential. They realized that 99% of people who train in the gym are not genetically elite, and they are constantly striving to overcome odds to become their best version of themselves. The PHAT Muscle Project is a movement that salutes that 35 year old mom working to lose 30 lbs, or that skinny kid who has trouble putting on muscle, and yes even body builders who step on stage or elite athletes. We are ALL our own project to become our best, that's what being part of the PHAT Muscle Project signifies. Lee, Y., Kim, W., Kim, K., Yoon, M., Cho, H., Shen, Y., . . . Kim, J. (2006). Berberine, a natural plant product, activates amp-activated protein kinase with beneficial metabolic effects in diabetic and insulin-resistant states. Diabetes, 55(8), 2256-64. A study by Hu and colleagues ( 2) investigated the lipid lowering effects of berberine. The results showed that supplementation with berberine for a period of 12 weeks produced average weight loss of 5 lb (2.26kg) in obese subjects, and significantly reduced blood lipid levels (23% decrease of triglyceride and 12.2% decrease of cholesterol levels) with no adverse reactions. Mayer, M. (2015). Type 2 Diabetes: Metabolomics Reveals Lipid Dysregulation. ThermoFischer.com Retrieved Jan 26th from: https://www.thermofisher.com/blog/proteomics/type-2-diabetes-metabolomics-reveals-lipid-dysregulation/ Ussing, D. E. (2021, July 23). Glucose Disposal Agents: What, when, why, and how? Retrieved October 21, 2022, from https://www.only-approved.com/blog/glucose-disposal-agents-what-when-why-and-how/

Benefits of Glucose Disposal Agents

While there are no side effects to taking a glucose disposal agent, there are some precautions. The most common problem is hypoglycemia (low blood sugar), which can be caused by too much medication. Because the drug increases blood sugar levels, it should not be taken with insulin or other diabetes medications that lower blood sugar levels. Conclusion Feet problems caused by damaged nerves or poor blood flow that can lead to serious skin infections, ulcerations, and in some severe cases, amputation Chromium: No effects in healthy individuals in regards to glucose tolerance, weight-loss or resistance training. Might be beneficial for people with diabetes.

Yes: Glucose Disposal Agents. Glucose Disposal Agents (GDAs), also known as insulin mimetic or nutrition partitioning agents are dietary supplements that can tweak the systems by which fat is stored on your body, and encourage them instead to allow you to build more muscle. What Are Glucose Disposal Agents? Suksomboon, N., Poolsup, N., & Yuwanakorn, A. (2014). Systematic review and meta-analysis of the efficacy and safety of chromium supplementation in diabetes. Journal of Clinical Pharmacy and Therapeutics, 39(3), 292-306 Berberine is a substance found in several plants including European barberry, goldenseal, goldthread, Oregon grape, phellodendron, and tree turmeric. It has been used as a traditional medicine to treat a variety of conditions and is particularly effective at lowering blood sugar levels. This is believed to be due to a number of mechanisms. Specifically, berberine is believed to improve insulin sensitivity and reduce glucose production in the liver. In fact, it has been compared to the type 2 diabetes medication, Metformin, as it exhibited exactly the same effects on blood glucose, but with additional anti-obesity and anti-inflammatory properties. The potent anti-diabetic properties of berberine are due to improved function of beta-cells in the pancreas, prompting the release of insulin, lowering lipid levels and regulating glucose and lipid metabolism. Wu, A. H., Spicer, D., Stanczyk, F. Z., Tseng, C. C., Yang, C. S., & Pike, M. C. (2012). Effect of 2-month controlled green tea intervention on lipoprotein cholesterol, glucose, and hormone levels in healthy postmenopausal women. Cancer prevention research (Philadelphia, Pa.), 5(3), 393-402.Chromiumis an essential element that the body requires in trace amounts and is used as a dietary supplement. It is part of a molecule called chromodulin, which helps the hormone insulin perform its actions in the body. Chromium picolinate comprises the mineral chromium attached to three molecules of picolinic acid. It is absorbed better than standard chromium and for this reason, is commonly used in dietary supplements. It provides a number of health benefits including improving insulin sensitivity, the control of blood glucose levels and the control of blood lipid levels. Chromium levels decrease with age and while dietary chromium is poorly absorbed, chromium picolinate is the most effective form of chromium supplementation due to its greater bioavailability compared with other types. As a non-diabetic, when you consume a meal that causes a spike in blood glucose, insulin will naturally be secreted and glucose will be shuttled adequately. Further, since you will likely be in a constant state of recovery from training and replenishing glycogen, your body will be highly receptive to the glucose you are consuming. Alpha lipoic acid supplementation enhanced lipid profiles and blood glucose control, according to another meta-analysis. What Does A Glucose Disposal Agent Affect? All delivery times stated are estimated, and we make every effort to deliver goods within the stated timescale. However delays are occasionally inevitable due to unforeseen circumstances. Banaba leaf extract: The research has not adequately tested its effects; as it was part of a 12-week protocol with a nutrition and training intervention from a full team of experts. Further, it did not alter the glucose-AUC in response to an OGTT. Lastly, it has not been tested in non-diabetic, healthy trained individuals.

When it comes to glucose disposal agents, the ingredients are key. Glucose disposal agents can play an important role with insulin sensitivity and the management of blood glucose levels. They help your body to take up more glucose (a type of sugar) from your blood by increasing the number of insulin receptors in your cells. Henriksen, E. (2006). Exercise training and the antioxidant α-lipoic acid in the treatment of insulin resistance and type 2 diabetes. Free Radical Biology and Medicine, 40(1), 3-12.Lan, J., Zhao, Y., Dong, F., Yan, Z., Zheng, W., Fan, J., & Sun, G. (2015). Meta-analysis of the effect and safety of berberine in the treatment of type 2 diabetes mellitus, hyperlipemia and hypertension. Journal of Ethnopharmacology, 161, 69-81 Thank you for dropping us a line about Time 4 GDA Glucose Disposal Agent. My name is Brian Batcheldor, I consult to Time 4 Nutrition on all matters relating to research and development. In the formulation of a Glucose Disposal Agent formula, there are a few questions we have to ask of ingredients, but there are at least as many hurdles to clear in getting a finished product out there. Of course, number one will always be safety, closely followed by efficacy. Financial viability and sustainability then enter the equation, this is where the wheels start to fall off for Alpha Lipoic Acid. Ellulu, M. S., Patimah, I., Khaza’ai, H., Rahmat, A., & Abed, Y. (2016). Obesity and inflammation: the linking mechanism and the complications. Archives of medical science : AMS, 13(4), 851-863. While the metformin group still made gains, this study shows how the mechanisms of many GDAs may not be beneficial for muscle hypertrophy or strength for individuals performing resistance training.