We know that millions of people live in chronic pain every day, a vast majority of whom have musculoskeletal conditions such as arthritis. For many of them current treatments are not effective. People living with pain have told us that pain is complex and multidimensional. Research into pain needs to reflect this and understanding more about the psychological and social factors that are important in chronic pain is critical to improve our understanding of the underlying biological mechanisms, holistically, tolead the way to more innovative treatments. I'm confident that research funded through the APDP initiative will help transform the lives of people affected by chronic pain." MRC is supported by Biotechnology and Biological Sciences Research Council and Economic and Social Research Council and partners with Versus Arthritis, Health Data Research UK (HDR UK) and Eli Lilly. evidence that the applicants provide an existing physical environment of cross-sector collaboration, with strong relationships with multiple key stakeholder groups and academic consortium members to support research and innovation After I’d let it go and was at her house, after a long uncomfortable conversation with her family about this incident because her family found out, I found out that that wasn’t the only time, I had to be strong and once again stood at her side and told her it was gonna be ok and that I wasn’t leaving her because I was still hoping to stay with her and swore on everything I hold close to me that I’d it happened again, I can’t sleep and I figured this post would help me a little but idk yet This call for funding is to support the establishment of a pain research data hub over three years. It is anticipated that the hub will continue to grow in scale and ambition beyond the three years, evolving into a sustainable coordinated and integrated national resource for pain research.

The work being carried out by Bristol researchers will also include the use of data from the world-renowned health study Children of the Nineties. Researchers will ask people taking part in the study to tell them about their pain, and will find out how many are living with pain as well as the impact that this has on their daily lives including, mental health, relationships, social lives, work and other important details. By looking at how daily life and pain are connected, the research team will have a clearer understanding of what it means to live with pain, and what could help in the management of their pain. Development of a robust UK-wide health data infrastructure to enable long-term impact and persistence. One of our Patient Insight Partners (PIP) provided the analogy: “You have to put books in the library to enhance knowledge.” The proposed use of innovative approaches to data discovery, standardisation, curation and cleaning, along with automation and a scalable secure infrastructure will create a powerful resource, that will be informed by what matters to people living with chronic pain. The ability to link pain cohorts to multi-dimensional routine health and non-health related datasets UK-wide. Alleviate joins an established network of Health Data Research Hubs, led by HDR UK and funded through UKRI’s Industry Strategy Challenge Fund, which aim to maximise insights and innovations from health data.

Multidisciplinary consortia

provide services to meet the needs of researchers, NHS, industry, charities, innovators and, ultimately, people with pain and the public synergising research across existing data hubs whilst bringing in innovative research from other domains which will significantly enhance scientific knowledge

The aim of the data hub as a platform is two-fold. Firstly, it will work to bring together, curate and improve existing data sets that are valuable to the chronic pain research community. We aim to develop a questionnaire-based assessment that captures ACEs. We will analyse current approaches to see which ones work best. Alongside this we will use people’s first-hand accounts, to ensure that lived experiences of ACEs and chronic pain, are accurately reflected in our approach. Working with patient partners we will bring together this information to develop and test a new ACE questionnaire (the CAPE ACEQ). Pain Hub, also seen as Painhub, is a popular online catchphrase that signifies emotional pain or sadness and is most commonly used as a reaction to or alongside sad, tragic, or "painful" content, similar to the Pain format.

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leading many HDR UK initiatives: Phenomics portal, Scottish Data Federation, Multiomics project, Biorepository management software, Imaging, open Connector, ATLAS Chronic pain is pain that lasts more than 3 months or longer than expected for healing after surgery, injury or a condition. The cause may also be unknown. It is sometimes called 'persistent pain'. It can be a difficult to treat and balancing treatment options is vital. You must be a UK research organisation eligible for Medical Research Council funding. This includes: experience as a data processor for several health boards, Scottish Government, and many UK and international research cohorts make data sets available in accordance with the principles for participation and discoverable through the Gateway

other staff, only for staff who will be dedicated to the establishment of the hub, or whose time working on the project can be fully supported by an auditable record for its duration (pool staff or staff whose time will be shared with other projects or activities and will not be supported by an auditable record should be requested under the ‘other directly allocated costs’ heading) It is also a debilitating feature of long-term conditions including arthritis, cancer, diabetes and dementia. There are links between exposure to multiple ACEs and social deprivation and the likelihood of ACE exposure is higher for boys, and for children of a young mother. Although there is good evidence that ACEs contribute to health inequalities, there is no widespread screening or systematic approach to reducing long term harms. Reasons for this include limitations in existing assessment approaches, and little consideration of other factors that might increase vulnerability. Consortium Against Pain in Equality (CAPE), led by Professor Tim Hales, University of Dundee, researching the impact of adverse childhood experiences on chronic pain and responses to treatment Support research projects to reveal new and improved treatments across diverse chronic and debilitating pain conditions.

evidence that the proposed hub, the data it plans to gather and the resources it will provide are guided by the needs of users and stakeholders, including people with pain and the public Many of these patients would go to one of these professionals, get treatment, go home and do nothing till the next treatment.