Yan B, et al. SARS-CoV-2 drives JAK1/2-dependent local complement hyperactivation. Sci Immunol. 2021. https://doi.org/10.1126/sciimmunol.abg0833. ColdZyme mouth spray maintains epithelial integrity and dampens innate immune activation upon SARS-CoV-2 infection of NHBE cultures. Kowalski, H.; Maurer-Fogy, I.; Vriend, G.; Casari, G.; Beyer, A.; Blaas, D. Trypsin sensitivity of several human rhinovirus serotypes in their low pH-induced conformation. Virology 1989, 171, 611–614. [ Google Scholar] [ CrossRef]

Meðgöngutími smitsjúkdóms er tíminn fráútsetningu smits þangað til einkenna verður vart. Meðgöngutíminn er breytilegur eftir tegund veiru, allt frá hálfum degi upp í viku og fer eftir tegund veirunnar. 2 At the end of the study, a larger proportion in the CZ-MD group (70.6%) rated the effectiveness of their treatment as “very good” or “good”, as opposed to 60.1% in the placebo group ( p< 0.05). The weblink provided with the press release on more information about the study results only leads to the protocol, without posted results [ 46]. The other prospective open study, including a control group, reports only data in 267 of the 400 targeted participants per protocol [ 47, 49]. The absence of baseline information on the participants enrolled in both treatment groups (even their number per group is missing) precludes evaluation of the clinical significance of the manufacturer-claimed improvements in quality of life (expressed as area-under-the-curve (AUC), symptoms and rescue medication use during the first week [ 49]. Ou, X.; Liu, Y.; Lei, X.; Li, P.; Mi, D.; Ren, L.; Guo, L.; Guo, R.; Chen, T.; Hu, J.; et al. Characterization of spike glycoprotein of SARS-CoV-2 on virus entry and its immune cross-reactivity with SARS-CoV. Nat. Commun. 2020, 11, 1620. [ Google Scholar] [ CrossRef][ Green Version] Gralinski LE, et al. Complement activation contributes to severe acute respiratory syndrome coronavirus pathogenesis. MBio. 2018. https://doi.org/10.1128/mBio.01753-18. Suffering from a sore throat, runny nose or headache? There's no denying it: cold and flu season is upon us. But what's the difference between a cold and the full-blown flu, what's the best way to treat both and how can you speed up recovery?CZ-MD inactivated rhinovirus 1A: 91.7% (1.08 log10); rhinovirus 42: 92.8% (1.14 log10); hIV virus H3N2: 96.9% (1.51 log10); RSV: 99.9% (2.94 log10); adenovirus T2: 64.5% (0.45 log10); human coronavirus [ 38]. If you're nervous to switch on the overhead fan for fear of contamination through the vent, we've got good news for you. Modern planes use Hepa (high-efficiency particulate air) filters that capture more than 99.9% of airborne microbes in the filtered air.

A study conducted in Germany last year showed that ColdZyme significantly reduced cold symptoms and improved quality of life in people with the common cold, compared to the control group. The participants were asked to use ColdZyme (two sprays, six times per day). Over the course of seven days, researchers observed that ColdZyme significantly improved sore throat, nose congestion, and headache symptoms. Use of ColdZyme also significantly improved quality of life and significantly shortened disease duration. Chu, H.; Chan, J.F.; Yuen, T.T.; Shuai, H.; Yuan, S.; Wang, Y.; Hu, B.; Yio, C.C.Y.; Tsang, J.O.; Huagn, X.; et al. Comparative tropism, replication kinetics, and cell damage profiling of SARS-CoV-2 and SARS-CoV with implications for clinical manifestations, transmissibility, and laboratory studies of COVID-19: An observational study. Lancet Microbe 2020, 1, e14–e23. [ Google Scholar] [ CrossRef] One 2018 study into transmission of illnesses showed that aisle and middle seat passengers had a 4-5% chance of catching an infection, while window seat passengers have a 0-1% chance. This is because you will be sat within close proximity of fewer people and because window seat passengers tend to move around far less. Clarsund, M. Evaluation of ColdZyme mouth spray for the protection against common cold in elite athletes to reduce unwanted absence from training and competition. Open J. Resp. Dis. 2017, 7, 103–109. [ Google Scholar] [ CrossRef][ Green Version] Wat, Dennis. The common cold: a review of the literature, European Journal of Internal Medicine. 15 (2004): 79-88

Initiatives

ColdZyme® mouth spray protects from BA.1 and BA.4/5 infection and intracellular (IC) C3 activation in primary human bronchial epithelial (NHBE) cells